Extracellular Matrix Scaffolds for Tissue Engineering and Regenerative Medicine

The extracellular matrix is produced by the resident cells in tissues and organs, and secreted into the surrounding medium to provide biophysical and biochemical support to the surrounding cells due to its content of diverse bioactive molecules. Recently, the extracellular matrix has been used as a...

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Podrobná bibliografie
Vydáno v:	Current stem cell research & therapy Ročník 12; číslo 3; s. 233 - 246
Hlavní autoři:	Yi, Sheng, Ding, Fei, Gong, Leiiei, Gu, Xiaosong
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United Arab Emirates 01.04.2017
Témata:	Bone and Bones - injuries Bone and Bones - pathology Bone and Bones - surgery Extracellular Matrix - chemistry Extracellular Matrix - metabolism Extracellular Matrix Proteins - therapeutic use Heart Humans Intestines - injuries Intestines - pathology Intestines - surgery Kidney - injuries Kidney - pathology Kidney - surgery Liver - injuries Liver - pathology Liver - surgery Lung - pathology Lung - surgery Nerve Tissue - injuries Nerve Tissue - pathology Nerve Tissue - surgery Regenerative Medicine - methods Skin - injuries Skin - pathology Tissue Engineering - methods Tissue Scaffolds Translational Medical Research Urinary Bladder - injuries Urinary Bladder - pathology Urinary Bladder - surgery Wound Healing - drug effects biological scaffold clinical application tissue engineering tissue repair and regeneration The extracellular matrix microenviroment
ISSN:	2212-3946
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Popis
Shrnutí:	The extracellular matrix is produced by the resident cells in tissues and organs, and secreted into the surrounding medium to provide biophysical and biochemical support to the surrounding cells due to its content of diverse bioactive molecules. Recently, the extracellular matrix has been used as a promising approach for tissue engineering. Emerging studies demonstrate that extracellular matrix scaffolds are able to create a favorable regenerative microenvironment, promote tissue-specific remodeling, and act as an inductive template for the repair and functional reconstruction of skin, bone, nerve, heart, lung, liver, kidney, small intestine, and other organs. In the current review, we will provide a critical overview of the structure and function of various types of extracellular matrix, the construction of three-dimensional extracellular matrix scaffolds, and their tissue engineering applications, with a focus on translation of these novel tissue engineered products to the clinic. We will also present an outlook on future perspectives of the extracellular matrix in tissue engineering and regenerative medicine.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	2212-3946
DOI:	10.2174/1574888X11666160905092513