Extracellular Matrix Scaffolds for Tissue Engineering and Regenerative Medicine

The extracellular matrix is produced by the resident cells in tissues and organs, and secreted into the surrounding medium to provide biophysical and biochemical support to the surrounding cells due to its content of diverse bioactive molecules. Recently, the extracellular matrix has been used as a...

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Bibliographic Details
Published in:Current stem cell research & therapy Vol. 12; no. 3; pp. 233 - 246
Main Authors: Yi, Sheng, Ding, Fei, Gong, Leiiei, Gu, Xiaosong
Format: Journal Article
Language:English
Published: United Arab Emirates 01.04.2017
Subjects:
Bone and Bones - injuries
Bone and Bones - pathology
Bone and Bones - surgery
Extracellular Matrix - chemistry
Extracellular Matrix - metabolism
Extracellular Matrix Proteins - therapeutic use
Heart
Humans
Intestines - injuries
Intestines - pathology
Intestines - surgery
Kidney - injuries
Kidney - pathology
Kidney - surgery
Liver - injuries
Liver - pathology
Liver - surgery
Lung - pathology
Lung - surgery
Nerve Tissue - injuries
Nerve Tissue - pathology
Nerve Tissue - surgery
Regenerative Medicine - methods
Skin - injuries
Skin - pathology
Tissue Engineering - methods
Tissue Scaffolds
Translational Medical Research
Urinary Bladder - injuries
Urinary Bladder - pathology
Urinary Bladder - surgery
Wound Healing - drug effects
biological scaffold
clinical application
tissue engineering
tissue repair and regeneration
The extracellular matrix
microenviroment
ISSN:2212-3946
Online Access:Get more information
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Summary:The extracellular matrix is produced by the resident cells in tissues and organs, and secreted into the surrounding medium to provide biophysical and biochemical support to the surrounding cells due to its content of diverse bioactive molecules. Recently, the extracellular matrix has been used as a promising approach for tissue engineering. Emerging studies demonstrate that extracellular matrix scaffolds are able to create a favorable regenerative microenvironment, promote tissue-specific remodeling, and act as an inductive template for the repair and functional reconstruction of skin, bone, nerve, heart, lung, liver, kidney, small intestine, and other organs. In the current review, we will provide a critical overview of the structure and function of various types of extracellular matrix, the construction of three-dimensional extracellular matrix scaffolds, and their tissue engineering applications, with a focus on translation of these novel tissue engineered products to the clinic. We will also present an outlook on future perspectives of the extracellular matrix in tissue engineering and regenerative medicine.
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ISSN:2212-3946
DOI:10.2174/1574888X11666160905092513