Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for the detection of pancreatic ductal adenocarcinoma

ObjectivePancreatic ductal adenocarcinoma (PDAC) is difficult to diagnose at resectable stage. Recent studies have suggested that extracellular vesicles (EVs) contain long RNAs. The aim of this study was to develop a diagnostic (d-)signature for the detection of PDAC based on EV long RNA (exLR) prof...

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Bibliographic Details
Published in:	Gut Vol. 69; no. 3; pp. 540 - 550
Main Authors:	Yu, Shulin, Li, Yuchen, Liao, Zhuan, Wang, Zheng, Wang, Zhen, Li, Yan, Qian, Ling, Zhao, Jingjing, Zong, Huajie, Kang, Bin, Zou, Wen-Bin, Chen, Kun, He, Xianghuo, Meng, Zhiqiang, Chen, Zhen, Huang, Shenglin, Wang, Peng
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.03.2020 BMJ Publishing Group LTD
Subjects:	Accuracy Adenocarcinoma Adolescent Adult Aged Aged, 80 and over Alpha-Globulins - genetics Antigens Area Under Curve Biomarkers CA-19-9 Antigen - blood Cancer therapies Carbohydrates Carcinoma, Pancreatic Ductal - blood Carcinoma, Pancreatic Ductal - diagnosis Carcinoma, Pancreatic Ductal - genetics Case-Control Studies Chemotherapy Child Claudin-1 - genetics diagnosis extracellular vesicle Extracellular Vesicles - metabolism Female Fibrinogen - genetics Gene expression Genomes Humans Keratin-19 - genetics Library collections long RNA Male Membrane Proteins - genetics Middle Aged Myelin and Lymphocyte-Associated Proteolipid Proteins - genetics Pancreas Pancreatic cancer pancreatic ductal adenocarcinoma Pancreatic Neoplasms - blood Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - genetics Pancreatitis Pancreatitis, Chronic - blood Patients Proteins Ribonucleic acid RNA RNA - blood RNA, Circular - blood RNA, Long Noncoding - blood RNA, Messenger - blood ROC Curve Sequence Analysis, RNA Studies Support Vector Machine Tissue inhibitor of metalloproteinase 1 Tissue Inhibitor of Metalloproteinase-1 - genetics Tumors Ubiquitin-Protein Ligases - genetics Young Adult California United States > US Massachusetts China Germany diagnosis long RNA extracellular vesicle pancreatic ductal adenocarcinoma
ISSN:	0017-5749, 1468-3288, 1468-3288
Online Access:	Get full text
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