Oxaliplatin, ATR inhibitor and anti-PD-1 antibody combination therapy controls colon carcinoma growth, induces local and systemic changes in the immune compartment, and protects against tumor rechallenge in mice

BackgroundColorectal cancer (CRC) is the third most common cancer type and one of the leading causes of cancer-related death worldwide. The treatment of advanced metastatic CRC relies on classical chemotherapy combinations (5-fluorouracil, oxaliplatin or irinotecan). However, their use is limited by...

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Bibliographic Details
Published in:	Journal for immunotherapy of cancer Vol. 13; no. 3; p. e010791
Main Authors:	Fauvre, Alexandra, Ursino, Chiara, Garambois, Veronique, Culerier, Elodie, Milazzo, Louis-Antoine, Vezzio-Vié, Nadia, Jeanson, Laura, Marchive, Candice, Andrade, Augusto Faria, Combes, Eve, Atis, Salima, Lossaint, Gérald, Quenet, François, Michaud, Henri-Alexandre, Khellaf, Lakhdar, Corbeau, Ileana, Tosi, Diego, Houede, Nadine, Bonnefoy, Nathalie, Sgarbura, Olivia, Gongora, Céline, Faget, Julien
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd 26.03.2025 BMJ Publishing Group LTD BMJ Publishing Group
Subjects:	Animals Antibodies Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Ataxia Basic and translational cancer immunology Bioluminescence Cancer therapies Cell death Cell Line, Tumor Chemotherapy Clinical trials Colonic Neoplasms - drug therapy Colonic Neoplasms - immunology Colonic Neoplasms - pathology Colorectal Cancer Female Gastric cancer Humans Immune Checkpoint Inhibitor Immune checkpoint inhibitors Immune Checkpoint Inhibitors - pharmacology Immunotherapy Kinases Lymphocytes Metastasis Mice Neutropenia Neutrophils Oxaliplatin - pharmacology Oxaliplatin - therapeutic use Patients Penicillin Programmed Cell Death 1 Receptor - antagonists & inhibitors T cell Tumors Colorectal Cancer Immune Checkpoint Inhibitor T cell Neutropenia
ISSN:	2051-1426, 2051-1426
Online Access:	Get full text
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