Anti-inflammatory approaches to ischaemic stroke prevention

Stroke is a major cause of neurological morbidity and mortality. Atherosclerosis is a major contributor to first and recurrent stroke. A growing evidence base indicates that inflammation is a key process in the pathogenesis of atherosclerosis, leading to thromboembolic events. In this review, we sum...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry Vol. 89; no. 2; pp. 211 - 218
Main Authors: Kelly, Peter J, Murphy, Sean, Coveney, Sarah, Purroy, Francisco, Lemmens, Robin, Tsivgoulis, Georgios, Price, Chris
Format: Journal Article
Language:English
Published: England BMJ Publishing Group LTD 01.02.2018
Subjects:
Anti-Inflammatory Agents - therapeutic use
Atherosclerosis
Brain Ischemia - immunology
Brain Ischemia - prevention & control
C-Reactive Protein - immunology
Cardiac arrhythmia
Cardiovascular disease
Clinical trials
Colchicine - therapeutic use
Coronary Disease - immunology
Coronary vessels
Dementia
Disease prevention
Embolisms
Health risk assessment
Heart attacks
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Inflammation
Inflammation - immunology
Intracranial Arteriosclerosis - immunology
Plaque, Atherosclerotic - immunology
Proteins
Recurrence
Stroke
Stroke - immunology
Stroke - prevention & control
Studies
Systematic review
Uric acid
stroke
ISSN:0022-3050, 1468-330X, 1468-330X
Online Access:Get full text
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Description
Summary:Stroke is a major cause of neurological morbidity and mortality. Atherosclerosis is a major contributor to first and recurrent stroke. A growing evidence base indicates that inflammation is a key process in the pathogenesis of atherosclerosis, leading to thromboembolic events. In this review, we summarise the evidence linking inflammation to stroke risk and discuss clinical trials addressing the ’inflammation hypothesis' in coronary disease and stroke. Trial registration number CONVINCE trial ClinicalTrials.gov number; NCT 02898610; Pre-results.
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ISSN:0022-3050
1468-330X
1468-330X
DOI:10.1136/jnnp-2016-314817