Subepithelial collagen in intestinal malabsorption

Intestinal biopsies from 146 patients with adult coeliac disease and 13 patients with intestinal villous atrophy of different aetiology were assessed for the presence of subepithelial collagen and compared with a group of 20 control subjects. Subepithelial collagen was a common and non-specific find...

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Vydáno v:Gut Ročník 16; číslo 1; s. 18 - 22
Hlavní autoři: Bossart, R, Henry, K, Booth, C C, Doe, W F
Médium: Journal Article
Jazyk:angličtina
Vydáno: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.01.1975
BMJ Publishing Group LTD
Témata:
Adult
Agammaglobulinemia - pathology
Atrophy - pathology
Basement Membrane - analysis
Biopsy
Celiac Disease - diet therapy
Celiac Disease - pathology
Collagen - analysis
Epithelial Cells
Epithelium - analysis
Epithelium - pathology
Glutens
Humans
Intestinal Diseases - pathology
Jejunum - analysis
Jejunum - pathology
Malabsorption Syndromes - pathology
Strongyloidiasis - pathology
Whipple Disease - pathology
ISSN:0017-5749, 1468-3288, 1458-3288
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Shrnutí:Intestinal biopsies from 146 patients with adult coeliac disease and 13 patients with intestinal villous atrophy of different aetiology were assessed for the presence of subepithelial collagen and compared with a group of 20 control subjects. Subepithelial collagen was a common and non-specific finding observed in intestinal biopsies from patients suffering from adult coeliac disease (36%) and tropical sprue. In adult coeliac disease the described subepithelial changes usually regress following treatment, though marked subepithelial collagen deposition may indicate a poor prognosis. The study showed that the presence of marked subepithelial collagen in a flat jejunal biopsy does not define a separate clinical entity.
Bibliografie:local:gutjnl;16/1/18
href:gutjnl-16-18.pdf
PMID:49285
istex:6A44DDB56DC7E52F003FB117506960B880E25091
ark:/67375/NVC-7WNP4WX4-1
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0017-5749
1468-3288
1458-3288
DOI:10.1136/gut.16.1.18