Absence of genetic linkage of chromosome 5q31 with asthma and atopy in the general population

BACKGROUND: Clinical asthma is associated with increased serum total immunoglobulin E (IgE), atopy (skin prick test positivity to common aeroallergens), and bronchial hyperreactivity (BHR) to non-specific stimuli (positive methacholine challenge test). A region on chromosome 5q31-33 has been linked...

Full description

Saved in:
Bibliographic Details
Published in:Thorax Vol. 52; no. 9; pp. 816 - 817
Main Authors: Kamitani, A, Wong, Z Y, Dickson, P, van Herwerden, L, Raven, J, Forbes, A B, Abramson, M J, Walters, E H, Harrap, S B
Format: Journal Article
Language:English
Published: London BMJ 01.09.1997
BMJ Publishing Group LTD
BMJ Group
Subjects:
Adult
Alleles
Asthma - genetics
Biological and medical sciences
Bronchial Hyperreactivity - genetics
Chromosomes, Human, Pair 5 - genetics
Chronic obstructive pulmonary disease, asthma
Genetic Linkage
Genetic Markers
Humans
Hypersensitivity - genetics
Medical sciences
Microsatellite Repeats
Pneumology
Human
Allergy
Immunopathology
Genetic inheritance
Linkage
Respiratory disease
Genetics
Chromosome 5
Obstructive pulmonary disease
Asthma
Atopy
ISSN:0040-6376, 1468-3296
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND: Clinical asthma is associated with increased serum total immunoglobulin E (IgE), atopy (skin prick test positivity to common aeroallergens), and bronchial hyperreactivity (BHR) to non-specific stimuli (positive methacholine challenge test). A region on chromosome 5q31-33 has been linked with increased total serum IgE and BHR. A study of the genetic linkage of this region with clinical asthma and atopy was therefore undertaken. METHODS: A polymorphic microsatellite marker in chromosome 5q31 (D5S399) was studied in 119 sibling pairs recruited from the general population who shared asthma, atopy, and/or BHR. Based on our population distribution of 13 different alleles, it was expected that by chance alone sibling pairs would share on average 1.24 alleles and that a significant excess would indicate genetic linkage. RESULTS: No evidence of linkage was found in 45 siblings concordant for asthma (shared alleles = 1.09, p = 0.95), in 103 sibling pairs with atopy (shared alleles = 1.18, p = 0.82), in 51 sibling pairs with BHR (shared alleles = 1.22, p = 0.62), or in 68 sibling pairs who shared atopy in the absence of BHR (shared alleles = 1.22, p = 0.61). A slight non-significant excess of shared alleles (1.44, p = 0.11) was observed in siblings who shared BHR without atopy. CONCLUSIONS: No evidence of genetic linkage of chromosome 5q31 with either clinical asthma or atopy was therefore detected in the population studied. Linkage between chromosome 5q and BHR needs further investigation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.52.9.816