Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization

The cytochrome P450 2D6 (CYP2D6) enzyme contributes to the metabolism and/or bioactivation of approximately 25% of clinically used drugs. The CYP2D6 gene locus is highly polymorphic and complex, and variants within this gene locus affect CYP2D6 enzymatic function resulting in a wide range of metabol...

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Veröffentlicht in:	Current drug metabolism Jg. 15; H. 2; S. 218
Hauptverfasser:	Hicks, J Kevin, Swen, Jesse J, Gaedigk, Andrea
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands 01.02.2014
Schlagworte:	Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Genetic Testing - methods Genetic Variation Genotype Humans Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - metabolism Pharmacogenetics - methods Phenotype Polymorphism, Genetic
ISSN:	1875-5453, 1875-5453
Online-Zugang:	Weitere Angaben
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