Implication of alpha-Klotho as the predictive factor of stress

Stress is known as a risk factor for both mental and physical health problems. While stress is known as one of the major health problems in modern society, a biomarker of stress has not yet been well established. In the present study, we focused on the serum levels of α-Klotho (αKl) as a possible ob...

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Bibliographic Details
Published in:Journal of investigative medicine Vol. 67; no. 7; pp. 1082 - 1086
Main Authors: Nakanishi, Kaori, Nishida, Makoto, Taneike, Manabu, Yamamoto, Ryohei, Adachi, Hiroyoshi, Moriyama, Toshiki, Yamauchi-Takihara, Keiko
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 01.10.2019
Sage Publications Ltd
Subjects:
Age
Biochemical markers
Biological markers
Biomarkers
Calcification
Cardiovascular disease
Clinical assessment
Coronary vessels
Counseling services
Cytokines
Family medical history
Health problems
Health status
Inflammation
Laboratories
Males
Management
Mental disorders
Mental health
Mental health care
Mental health services
Modern society
Psychiatry
Psychological distress
Questionnaires
Risk factors
Serum
Sleep
Smoking
Stress
Stress management
Variables
Womens health
Japan
α-Klotho
biomarker
kessler screening scale for psychological distress
psychological stress
interleukin-6
ISSN:1081-5589, 1708-8267, 1708-8267
Online Access:Get full text
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Summary:Stress is known as a risk factor for both mental and physical health problems. While stress is known as one of the major health problems in modern society, a biomarker of stress has not yet been well established. In the present study, we focused on the serum levels of α-Klotho (αKl) as a possible objective biomarker of stress. Subjects included apparently healthy individuals who underwent a health examination in the Osaka University Health and Counseling Center. Physical and biochemical parameters were obtained from all subjects. Information regarding the lifestyle of each individual was obtained via questionnaires. Among male subjects, serum levels of soluble αKl (sαKl) were significantly elevated in subjects who had poor stress management and unsatisfactory sleep, suggesting that stress management and sleeping conditions influenced the serum levels of sαKl. The total Kessler Screening Scale for Psychological Distress (K6) score was significantly increased in subjects who reported experiencing considerable stress, had poor stress management and unsatisfactory sleep. Since serum levels of sαKl showed the same tendency as the K6 score in terms of the relationship between stress management and sleeping conditions in male subjects, increased sαKl levels could be associated with considerable psychological stress in healthy men.
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ISSN:1081-5589
1708-8267
1708-8267
DOI:10.1136/jim-2018-000977