Implication of alpha-Klotho as the predictive factor of stress

Stress is known as a risk factor for both mental and physical health problems. While stress is known as one of the major health problems in modern society, a biomarker of stress has not yet been well established. In the present study, we focused on the serum levels of α-Klotho (αKl) as a possible ob...

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Vydáno v:	Journal of investigative medicine Ročník 67; číslo 7; s. 1082 - 1086
Hlavní autoři:	Nakanishi, Kaori, Nishida, Makoto, Taneike, Manabu, Yamamoto, Ryohei, Adachi, Hiroyoshi, Moriyama, Toshiki, Yamauchi-Takihara, Keiko
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Los Angeles, CA SAGE Publications 01.10.2019 Sage Publications Ltd
Témata:	Age Biochemical markers Biological markers Biomarkers Calcification Cardiovascular disease Clinical assessment Coronary vessels Counseling services Cytokines Family medical history Health problems Health status Inflammation Laboratories Males Management Mental disorders Mental health Mental health care Mental health services Modern society Psychiatry Psychological distress Questionnaires Risk factors Serum Sleep Smoking Stress Stress management Variables Womens health Japan α-Klotho biomarker kessler screening scale for psychological distress psychological stress interleukin-6
ISSN:	1081-5589, 1708-8267, 1708-8267
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Abstract	Stress is known as a risk factor for both mental and physical health problems. While stress is known as one of the major health problems in modern society, a biomarker of stress has not yet been well established. In the present study, we focused on the serum levels of α-Klotho (αKl) as a possible objective biomarker of stress. Subjects included apparently healthy individuals who underwent a health examination in the Osaka University Health and Counseling Center. Physical and biochemical parameters were obtained from all subjects. Information regarding the lifestyle of each individual was obtained via questionnaires. Among male subjects, serum levels of soluble αKl (sαKl) were significantly elevated in subjects who had poor stress management and unsatisfactory sleep, suggesting that stress management and sleeping conditions influenced the serum levels of sαKl. The total Kessler Screening Scale for Psychological Distress (K6) score was significantly increased in subjects who reported experiencing considerable stress, had poor stress management and unsatisfactory sleep. Since serum levels of sαKl showed the same tendency as the K6 score in terms of the relationship between stress management and sleeping conditions in male subjects, increased sαKl levels could be associated with considerable psychological stress in healthy men.
AbstractList	Stress is known as a risk factor for both mental and physical health problems. While stress is known as one of the major health problems in modern society, a biomarker of stress has not yet been well established. In the present study, we focused on the serum levels of α-Klotho (αKl) as a possible objective biomarker of stress. Subjects included apparently healthy individuals who underwent a health examination in the Osaka University Health and Counseling Center. Physical and biochemical parameters were obtained from all subjects. Information regarding the lifestyle of each individual was obtained via questionnaires. Among male subjects, serum levels of soluble αKl (sαKl) were significantly elevated in subjects who had poor stress management and unsatisfactory sleep, suggesting that stress management and sleeping conditions influenced the serum levels of sαKl. The total Kessler Screening Scale for Psychological Distress (K6) score was significantly increased in subjects who reported experiencing considerable stress, had poor stress management and unsatisfactory sleep. Since serum levels of sαKl showed the same tendency as the K6 score in terms of the relationship between stress management and sleeping conditions in male subjects, increased sαKl levels could be associated with considerable psychological stress in healthy men. Stress is known as a risk factor for both mental and physical health problems. While stress is known as one of the major health problems in modern society, a biomarker of stress has not yet been well established. In the present study, we focused on the serum levels of α-Klotho (αKl) as a possible objective biomarker of stress. Subjects included apparently healthy individuals who underwent a health examination in the Osaka University Health and Counseling Center. Physical and biochemical parameters were obtained from all subjects. Information regarding the lifestyle of each individual was obtained via questionnaires. Among male subjects, serum levels of soluble αKl (sαKl) were significantly elevated in subjects who had poor stress management and unsatisfactory sleep, suggesting that stress management and sleeping conditions influenced the serum levels of sαKl. The total Kessler Screening Scale for Psychological Distress (K6) score was significantly increased in subjects who reported experiencing considerable stress, had poor stress management and unsatisfactory sleep. Since serum levels of sαKl showed the same tendency as the K6 score in terms of the relationship between stress management and sleeping conditions in male subjects, increased sαKl levels could be associated with considerable psychological stress in healthy men.Stress is known as a risk factor for both mental and physical health problems. While stress is known as one of the major health problems in modern society, a biomarker of stress has not yet been well established. In the present study, we focused on the serum levels of α-Klotho (αKl) as a possible objective biomarker of stress. Subjects included apparently healthy individuals who underwent a health examination in the Osaka University Health and Counseling Center. Physical and biochemical parameters were obtained from all subjects. Information regarding the lifestyle of each individual was obtained via questionnaires. Among male subjects, serum levels of soluble αKl (sαKl) were significantly elevated in subjects who had poor stress management and unsatisfactory sleep, suggesting that stress management and sleeping conditions influenced the serum levels of sαKl. The total Kessler Screening Scale for Psychological Distress (K6) score was significantly increased in subjects who reported experiencing considerable stress, had poor stress management and unsatisfactory sleep. Since serum levels of sαKl showed the same tendency as the K6 score in terms of the relationship between stress management and sleeping conditions in male subjects, increased sαKl levels could be associated with considerable psychological stress in healthy men.
Author	Yamamoto, Ryohei Yamauchi-Takihara, Keiko Nishida, Makoto Adachi, Hiroyoshi Moriyama, Toshiki Taneike, Manabu Nakanishi, Kaori
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Cites_doi	10.1155/2015/172064 10.1530/EC-14-0031 10.1016/j.bbrc.2010.06.110 10.3389/fendo.2017.00323 10.1002/mpr.1349 10.1016/j.ijpsycho.2015.04.008 10.1165/ajrcmb.22.1.3554 10.1093/ntr/ntp144 10.1074/jbc.M115.655431 10.1016/j.cca.2017.11.007 10.1038/nrcardio.2012.45 10.1136/heartjnl-2013-304746 10.1016/j.psychres.2017.03.012 10.3389/fnbeh.2015.00010 10.5551/jat.30635 10.1038/tp.2015.81 10.1016/j.beem.2010.08.014 10.1017/S0033291702006074 10.2478/v10153-011-0091-9 10.1038/srep14230 10.1097/MNH.0b013e32835422ad 10.1038/36285 10.1001/archpsyc.60.2.184 10.1109/IEMBS.2011.6090556 10.1074/jbc. M115.655431
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Copyright	American Federation for Medical Research 2019. No commercial re-use. See rights and permissions. Published by BMJ. 2019 American Federation for Medical Research 2019 American Federation for Medical Research 2019. No commercial re-use. See rights and permissions. Published by BMJ.
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Keywords	α-Klotho biomarker kessler screening scale for psychological distress psychological stress interleukin-6
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Snippet	Stress is known as a risk factor for both mental and physical health problems. While stress is known as one of the major health problems in modern society, a...
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SubjectTerms	Age Biochemical markers Biological markers Biomarkers Calcification Cardiovascular disease Clinical assessment Coronary vessels Counseling services Cytokines Family medical history Health problems Health status Inflammation Laboratories Males Management Mental disorders Mental health Mental health care Mental health services Modern society Psychiatry Psychological distress Questionnaires Risk factors Serum Sleep Smoking Stress Stress management Variables Womens health
Title	Implication of alpha-Klotho as the predictive factor of stress
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