Risk factors for progressive axonal degeneration of the retinal nerve fibre layer in multiple sclerosis patients

AimTo quantify structural and functional degeneration in the retinal nerve fibre layer (RNFL) of patients with multiple sclerosis (MS) over a 2-year time period, and to analyse the effect of prior optic neuritis (ON) as well as the duration and incidence of MS relapses.Methods166 MS patients and 120...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	British journal of ophthalmology Ročník 95; číslo 11; s. 1577 - 1582
Hlavní autori:	Garcia-Martin, Elena, Pueyo, Victoria, Almarcegui, Carmen, Martin, Jesus, Ara, Jose R, Sancho, Eva, Pablo, Luis E, Dolz, Isabel, Fernandez, Javier
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.11.2011 BMJ Publishing Group BMJ Publishing Group LTD
Predmet:	Acuity Adult Aged Atrophy Atrophy - pathology Atrophy - physiopathology Axons - pathology Biological and medical sciences Color vision Degeneration diagnostic tests/investigation Disease Disease Progression electrophysiology Epidemiologic Methods Female Ganglion cells GDx Humans Male Medical imaging Medical sciences Middle Aged Miscellaneous Multiple sclerosis Multiple Sclerosis - complications Multiple Sclerosis - pathology Multiple Sclerosis - physiopathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurodegeneration Neurology OCT Ophthalmology Optic nerve Optic Nerve - pathology Optic neuritis Optic Neuritis - etiology Optic Neuritis - pathology relapsing-remitting multiple sclerosis Retina Retinal Ganglion Cells - pathology Risk factors Structure-function relationships Studies Tomography Tomography, Optical Coherence - methods Visual Acuity - physiology Visual evoked potentials visual field visual fields Visual Fields - physiology visual pathway Young Adult California Human Progressive Nervous system diseases Multiple sclerosis Central nervous system disease Risk factor Retina Degeneration Ophthalmology Nerve fiber Inflammatory disease
ISSN:	0007-1161, 1468-2079, 1468-2079
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	AimTo quantify structural and functional degeneration in the retinal nerve fibre layer (RNFL) of patients with multiple sclerosis (MS) over a 2-year time period, and to analyse the effect of prior optic neuritis (ON) as well as the duration and incidence of MS relapses.Methods166 MS patients and 120 healthy controls underwent assessment of visual acuity and colour vision, visual field examination, optical coherence tomography, scanning laser polarimetry and visual evoked potentials (VEPs). All subjects were re-evaluated after a period of 12 and 24 months.ResultsChanges in the optic nerve were detected by structural measurements but not by functional assessments. Changes registered in MS patients were greater than changes in healthy controls (p<0.05). Eyes with previous ON showed a greater reduction of parameters in the baseline evaluation, but RNFL atrophy was not significantly greater in the longitudinal study. Patients with MS relapses showed a greater reduction of RNFL thickness and VEP amplitude compared with non-relapsing cases. Patients with and without treatment showed similar measurement reduction, but the non-treated group had a significantly higher increase in Expanded Disability Status Scale (p=0.029).ConclusionsMS causes progressive axonal loss in the optic nerve, regardless of a history of ON. This ganglion cell atrophy occurs in all eyes but is more marked in MS eyes than in healthy eyes.
Bibliografia:	PMID:21785155 ark:/67375/NVC-96X3J0ZX-8 istex:1C868B0FC1BE49B8E18839F80236583E18D1EA95 href:bjophthalmol-95-1577.pdf local:bjophthalmol;95/11/1577 Study partially presented at the ARVO meeting, May 2009. ArticleID:bjophthalmol199232 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23
ISSN:	0007-1161 1468-2079 1468-2079
DOI:	10.1136/bjo.2010.199232