An Insight of Scientific Developments in TSC for Better Therapeutic Strategy

Tuberous sclerosis complex (TSC) is a rare genetic disease, which is characterized by noncancerous tumors in multi-organ systems in the body. Mutations in the TSC1 or TSC2 genes are known to cause the disease. The resultant mutant proteins TSC1 (hamartin) and TSC2 (tuberin) complex evade its normal...

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Bibliographic Details
Published in:	Current topics in medicinal chemistry Vol. 20; no. 23; p. 2080
Main Authors:	Natarajan, Nalini, Thiruvenkatam, Vijay
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01.01.2020
Subjects:	Drug Development Genes, Tumor Suppressor - drug effects Humans Immunosuppressive Agents - chemistry Immunosuppressive Agents - pharmacology Sirolimus - chemistry Sirolimus - pharmacology Tuberous Sclerosis - drug therapy Tuberous Sclerosis - metabolism Tuberous Sclerosis Complex 1 Protein - antagonists & inhibitors Tuberous Sclerosis Complex 1 Protein - genetics Tuberous Sclerosis Complex 1 Protein - metabolism Tuberous Sclerosis Complex 2 Protein - antagonists & inhibitors Tuberous Sclerosis Complex 2 Protein - genetics Tuberous Sclerosis Complex 2 Protein - metabolism mTOR inhibition Coiled-coil sequence Protein-protein interaction Disruptive mutation Heat shock proteins Hypoxia Rapalogs treatment Tuberous sclerosis complex Crystal structure
ISSN:	1873-4294, 1873-4294
Online Access:	Get more information
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