Synaptic Interactions Between Serotonergic and Dopaminergic Systems in Parkinson's Disease

Since both serotonergic and dopaminergic afferents densely innervate many parts of the central nervous system, intact crosstalk between serotonin (5-HT) and dopamine (DA) transmission is essential for regulating synaptic plasticity in the striatum (STR), prefrontal cortex (PFC), and hippocampus (HPC...

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Vydáno v:Current neuropharmacology Ročník 23; číslo 9; s. 1021
Hlavní autoři: Marino, Gioia, Campanelli, Federica, Natale, Giuseppina, De Carluccio, Maria, Servillo, Federica, Ghiglieri, Veronica, Calabresi, Paolo
Médium: Journal Article
Jazyk:angličtina
Vydáno: United Arab Emirates 01.01.2025
Témata:
Animals
Dopamine - metabolism
Humans
Neuronal Plasticity - drug effects
Neuronal Plasticity - physiology
Parkinson Disease - metabolism
Parkinson Disease - physiopathology
Receptors, Serotonin - metabolism
Serotonin - metabolism
Synapses - metabolism
cognitive function
synaptic plasticity
Serotonin
neurotransmitter
dopamine
Parkinson’s disease
ISSN:1875-6190, 1875-6190
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Popis
Shrnutí:Since both serotonergic and dopaminergic afferents densely innervate many parts of the central nervous system, intact crosstalk between serotonin (5-HT) and dopamine (DA) transmission is essential for regulating synaptic plasticity in the striatum (STR), prefrontal cortex (PFC), and hippocampus (HPC). Experimental models have provided strong evidence of a synergistic action of DA and 5-HT convergent release in PFC, HPC, and STR to modulate motor control, learning, and memory processes. In this review, we will discuss the mechanisms underlying the actions of agonists and antagonists of 5-HT and DA receptors on striatal synaptic plasticity in physiological conditions and Parkinson's disease (PD), a movement disorder in which an imbalance of these two neurotransmitter systems has been hypothesized. This review will also discuss the interactions between 5-HT and DA in PFC and HPC, with particular regard to the influence of this crosstalk on synaptic plasticity and learning. Finally, we will provide an overview of how stimulation or inhibition of DA and 5- HT receptors affects these neurotransmitter expression levels in the three brain regions of interest.
Bibliografie:ObjectType-Article-1
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ISSN:1875-6190
1875-6190
DOI:10.2174/011570159X336597241217062042