Computational Structural Validation of CYP2C9 Mutations and Evaluation of Machine Learning Algorithms in Predicting the Therapeutic Outcomes of Warfarin

The study aimed to identify the key pharmacogenetic variable influencing the therapeutic outcomes of warfarin using machine learning algorithms and bioinformatics tools. Warfarin, a commonly used anticoagulant drug, is influenced by cytochrome P450 (CYP) enzymes, particularly CYP2C9. MLAs have been...

Full description

Bibliographic Details

Published in:	Current drug metabolism Vol. 24; no. 6; p. 466
Main Authors:	Sridharan, Kannan, Kumar, Thirumal, Manikandan, Suchetha, Prasanna, Gaurav, G, Lalitha, Al Banna, Rashed, Doss, George Priya
Format:	Journal Article
Language:	English
Published:	Netherlands 01.01.2023
Subjects:	CYP2C9 Warfarin Support vector machine Molecular Dynamics Simulation Machine learning algorithm
ISSN:	1875-5453, 1875-5453
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!