Spatially restricted tumour-associated and host-associated immune drivers correlate with the recurrence sites of pancreatic cancer

ObjectiveMost patients with pancreatic ductal adenocarcinoma (PDAC) will experience recurrence after resection. Here, we investigate spatially organised immune determinants of PDAC recurrence.DesignPDACs (n=284; discovery cohort) were classified according to recurrence site as liver (n=93/33%), lung...

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Veröffentlicht in:	Gut Jg. 72; H. 8; S. 1523 - 1533
Hauptverfasser:	Karamitopoulou, Eva, Wenning, Anna Silvia, Acharjee, Animesh, Zlobec, Inti, Aeschbacher, Pauline, Perren, Aurel, Gloor, Beat
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.08.2023 BMJ Publishing Group LTD
Schlagworte:	Actin Adenocarcinoma Biology Biomarkers cancer immunobiology Cancer therapies Carcinoma, Pancreatic Ductal - pathology CD45 antigen Chemokines Chemotherapy Cloning Dendritic cells Fibroblasts Granzyme B Histology Humans Immune response Immunofluorescence Immunogenicity immunohistopathology Inflammation Innate immunity Leukocytes Leukocytes (neutrophilic) Liver Metastases Metastasis Next-generation sequencing Pancreas Pancreatic cancer Pancreatic Neoplasms - pathology Pathology Patients Peritoneum Phenotypes Prognosis Proteomics Recurrence Signal transduction Smooth muscle Stromal cells Surgery Surveillance Transcriptomics Tumors γ-Interferon immunohistopathology pancreatic cancer cancer immunobiology immune response
ISSN:	0017-5749, 1468-3288, 1468-3288
Online-Zugang:	Volltext
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