Persistent alveolar inflammatory response in critically ill patients with COVID-19 is associated with mortality

IntroductionPatients with COVID-19-related acute respiratory distress syndrome (ARDS) show limited systemic hyperinflammation, but immunomodulatory treatments are effective. Little is known about the inflammatory response in the lungs and if this could be targeted using high-dose steroids (HDS). We...

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Published in:	Thorax Vol. 78; no. 9; pp. 912 - 921
Main Authors:	de Brabander, Justin, Boers, Leonoor S, Kullberg, Robert F J, Zhang, Shiqi, Nossent, Esther J, Heunks, Leo M A, Vlaar, Alexander P J, Bonta, Peter I, Schultz, Marcus J, van der Poll, Tom, Duitman, JanWillem, Nossent, E J, Duitman, J W, Saris, A, de Vries, H, Meijboom, L J, Bos, L D J, Reijnders, T D Y, Bontkes, H, Vlaar, A P J, Wiersinga, W J, Lutter, R, van der Poll, T, Bogaard, H J, Heunks, L, Algera, A G, Baarle, F, Beudel, M, Bomers, M, Bonta, P, Bos, L D, Botta, M, de Brabander, J, de Bree, G, de Bruin, S, Bugiani, M, Bulle, E, Buis, D T P, Chouchane, O, Cloherty, A, Dijkstra, M, Dongelmans, D A, Dujardin, R W G, Elbers, P, Fleuren, L, Geerlings, S, Geijtenbeek, T, Girbes, A, Goorhuis, B, Harris, V, Hemke, R, Hermans, S M, Horn, J, de Jong, M D, Koning, R, Lim, E H T, van Mourik, N, Nellen, J, Paulus, F, Peters, E, Pina-Fuentes, D A I, Preckel, B, Prins, J M, Raasveld, J, Reijnders, T, J de Rotte, M C F, Schinkel, M, Schultz, M J, Schrauwen, F A P, Schuurman, A, Schuurmans, J, Sigaloff, K, Slim, M A, Smeele, P, Smit, M, Stijnis, C S, Stilma, W, Teunissen, C, Thoral, P, Tsonas, A M, Tuinman, P R, van der Valk, M, Volleman, C, van Vugt, M, Wouters, D, Zwinderman, A H, Brouwer, M C, van de Beek, D, de Beer, F M, Claushuis, T A, Glas, G J, Hoogendijk, A J, van Hooijdonk, R T, Huson, M A, Juffermans, N P, Scicluna, B, Schouten, L R, van der Sluijs, K F, Wiewel, M A, Witteveen, E
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd and British Thoracic Society 01.09.2023 BMJ Publishing Group LTD
Subjects:	ARDS Biomarkers Body mass index Bronchoscopy Coronaviruses COVID-19 critical care Drug dosages Hypotheses innate immunity Intubation Laboratories Mortality Patients Plasma Proteins Respiratory distress syndrome Respiratory failure Respiratory infection Steroids Ventilators United States > US California COVID-19 critical care innate immunity ARDS respiratory infection bronchoscopy
ISSN:	0040-6376, 1468-3296, 1468-3296
Online Access:	Get full text
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