Prevalence of steatotic liver disease, advanced fibrosis and cirrhosis among community-dwelling overweight and obese individuals in the USA

BackgroundThere are limited prospective data among overweight and obese individuals on the prevalence of advanced fibrosis, and cirrhosis using advanced MRI-based methods in the USA. The aim of this study was to fill that gap in knowledge by prospectively determining the MRI-based prevalence of stea...

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Published in:Gut Vol. 73; no. 12; pp. 2045 - 2053
Main Authors: Yang, Alexander H, Tincopa, Monica A, Tavaglione, Federica, Ajmera, Veeral H, Richards, Lisa M, Amangurbanova, Maral, Butcher, Christian, Hernandez, Christie, Madamba, Egbert, Singh, Seema, Bettencourt, Ricki, Schnabl, Bernd, Sirlin, Claude B, Loomba, Rohit
Format: Journal Article
Language:English
Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.12.2024
BMJ Publishing Group LTD
Subjects:
Adult
Aged
Alcohol abuse
Alcohol use
Audits
Biomarkers
Body mass index
Body weight
California - epidemiology
Cirrhosis
Cohort analysis
Cross-Sectional Studies
Elasticity Imaging Techniques
Fatty Liver - diagnostic imaging
Fatty Liver - epidemiology
Female
FIBROSIS
Hepatitis
Hepatology
Humans
Independent Living
Laboratories
LIVER CIRRHOSIS
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - epidemiology
Liver Cirrhosis - etiology
Liver Cirrhosis - pathology
Liver diseases
Magnetic Resonance Imaging
Male
Metabolism
Middle Aged
Nomenclature
NONALCOHOLIC STEATOHEPATITIS
OBESITY
Obesity - complications
Obesity - epidemiology
Overweight
Overweight - complications
Overweight - epidemiology
Patients
Prevalence
Primary care
Prospective Studies
Questionnaires
United States - epidemiology
Womens health
United States
California
United States > US
FIBROSIS
LIVER CIRRHOSIS
OBESITY
NONALCOHOLIC STEATOHEPATITIS
ISSN:0017-5749, 1468-3288, 1468-3288
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Summary:BackgroundThere are limited prospective data among overweight and obese individuals on the prevalence of advanced fibrosis, and cirrhosis using advanced MRI-based methods in the USA. The aim of this study was to fill that gap in knowledge by prospectively determining the MRI-based prevalence of steatotic liver disease (SLD) and its subcategories, advanced fibrosis and cirrhosis among overweight and obese individuals residing in the USA.MethodsThis is a cross-sectional analysis of prospectively enrolled overweight or obese adults aged 40–75 years from primary care and community-based settings in Southern California. Participants were classified as having SLD if MRI proton density fat fraction ≥5%, and subclassified as metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction and alcohol-associated liver disease (MetALD) and alcohol-related liver disease (ALD) consistently with the new nomenclature guidance per AASLD–EASL–ALEH. Advanced fibrosis and cirrhosis were defined as magnetic resonance elastography (MRE) ≥3.63 kPa and MRE ≥4.67 kPa, respectively.ResultsThe cohort included 539 participants with mean (±SD) age of 51.5 (±13.1) years and body mass index of 32.6 (±6.2) kg/m2, respectively. The prevalence of SLD, advanced fibrosis and cirrhosis was 75%, 10.8% and 4.5%, respectively. The prevalence of MASLD, MetALD and ALD was 67.3%, 4.8% and 2.6%, respectively. There was no difference in prevalence of advanced fibrosis and cirrhosis among subcategories.ConclusionsUsing advanced MRI methods among community-dwelling overweight and obese adults, the prevalence of cirrhosis was 4.5%. Most common SLD subcategory was MASLD with 67% of individuals, whereas MetALD and ALD were less common. Systematic screening for advanced fibrosis among overweight/obese adults may be considered.
Bibliography:Original research
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ISSN:0017-5749
1468-3288
1468-3288
DOI:10.1136/gutjnl-2024-332917