Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study

Objective Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity—within the reference range and in the absence of pancreatitis—are associated with genetic single nucleotide polymorphisms (SNP), and whether these ide...

Full description

Saved in:

Bibliographic Details
Published in:	Gut Vol. 64; no. 4; pp. 646 - 656
Main Authors:	Weiss, Frank Ulrich, Schurmann, Claudia, Guenther, Annett, Ernst, Florian, Teumer, Alexander, Mayerle, Julia, Simon, Peter, Völzke, Henry, Radke, Dörte, Greinacher, Andreas, Kuehn, Jens-Peter, Zenker, Martin, Völker, Uwe, Homuth, Georg, Lerch, Markus M
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group LTD 01.04.2015
Subjects:	ABO Blood-Group System - physiology Adult Aged Aged, 80 and over Antigens Blood groups Consent Enzymes Female Fucosyltransferases - physiology Galactoside 2-alpha-L-fucosyltransferase Genetic Association Studies Genome-Wide Association Study Genomes Humans Lipase - blood Male Middle Aged Oils & fats Pancreatic cancer Pancreatitis, Chronic - epidemiology Pancreatitis, Chronic - genetics Polymorphism, Single Nucleotide Population Risk Assessment Rodents Studies Young Adult Pancreatic Enzymes Chronic Pancreatitis Linkage Analysis Glycosyltransferases Genetic Polymorphisms
ISSN:	0017-5749, 1468-3288, 1468-3288
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Objective Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity—within the reference range and in the absence of pancreatitis—are associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also associated with clinical pancreatitis. Methods Genome-wide association studies (GWAS) on phenotypes ‘serum lipase activity’ and ‘high serum lipase activity’ were conducted including 3966 German volunteers from the population-based Study-of-Health-in-Pomerania (SHIP). Lead SNPs associated on a genome-wide significance level were replicated in two cohorts, 1444 blood donors and 1042 pancreatitis patients. Results Initial discovery GWAS detected SNPs within or near genes encoding the ABO blood group specifying transferases A/B (ABO), Fucosyltransferase-2 (FUT2), and Chymotrypsinogen-B2 (CTRB2), to be significantly associated with lipase activity levels in asymptomatic subjects. Replication analyses in blood donors confirmed the association of FUT-2 non-secretor status (OR=1.49; p=0.012) and ABO blood-type-B (OR=2.48; p=7.29×10−8) with high lipase activity levels. In pancreatitis patients, significant associations were found for FUT-2 non-secretor status (OR=1.53; p=8.56×10−4) and ABO-B (OR=1.69, p=1.0×10−4) with chronic pancreatitis, but not with acute pancreatitis. Conversely, carriers of blood group O were less frequently affected by chronic pancreatitis (OR=0.62; p=1.22×10−05) and less likely to have high lipase activity levels (OR=0.59; p=8.14×10−05). Conclusions These are the first results indicating that ABO blood type-B as well as FUT2 non-secretor status are common population-wide risk factors for developing chronic pancreatitis. They also imply that, even within the reference range, elevated lipase activities may indicate subclinical pancreatic injury in asymptomatic subjects.
AbstractList	Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity-within the reference range and in the absence of pancreatitis-are associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also associated with clinical pancreatitis. Genome-wide association studies (GWAS) on phenotypes 'serum lipase activity' and 'high serum lipase activity' were conducted including 3966 German volunteers from the population-based Study-of-Health-in-Pomerania (SHIP). Lead SNPs associated on a genome-wide significance level were replicated in two cohorts, 1444 blood donors and 1042 pancreatitis patients. Initial discovery GWAS detected SNPs within or near genes encoding the ABO blood group specifying transferases A/B (ABO), Fucosyltransferase-2 (FUT2), and Chymotrypsinogen-B2 (CTRB2), to be significantly associated with lipase activity levels in asymptomatic subjects. Replication analyses in blood donors confirmed the association of FUT-2 non-secretor status (OR=1.49; p=0.012) and ABO blood-type-B (OR=2.48; p=7.29×10(-8)) with high lipase activity levels. In pancreatitis patients, significant associations were found for FUT-2 non-secretor status (OR=1.53; p=8.56×10(-4)) and ABO-B (OR=1.69, p=1.0×10(-4)) with chronic pancreatitis, but not with acute pancreatitis. Conversely, carriers of blood group O were less frequently affected by chronic pancreatitis (OR=0.62; p=1.22×10(-05)) and less likely to have high lipase activity levels (OR=0.59; p=8.14×10(-05)). These are the first results indicating that ABO blood type-B as well as FUT2 non-secretor status are common population-wide risk factors for developing chronic pancreatitis. They also imply that, even within the reference range, elevated lipase activities may indicate subclinical pancreatic injury in asymptomatic subjects. Objective Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity-within the reference range and in the absence of pancreatitis-are associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also associated with clinical pancreatitis. Methods Genome-wide association studies (GWAS) on phenotypes 'serum lipase activity' and 'high serum lipase activity' were conducted including 3966 German volunteers from the population-based Study-of-Health-in-Pomerania (SHIP). Lead SNPs associated on a genome-wide significance level were replicated in two cohorts, 1444 blood donors and 1042 pancreatitis patients. Results Initial discovery GWAS detected SNPs within or near genes encoding the ABO blood group specifying transferases A/B (ABO ), Fucosyltransferase-2 (FUT2 ), and Chymotrypsinogen-B2 (CTRB2 ), to be significantly associated with lipase activity levels in asymptomatic subjects. Replication analyses in blood donors confirmed the association of FUT-2 non-secretor status (OR=1.49; p=0.012) and ABO blood-type-B (OR=2.48; p=7.29x10-8 ) with high lipase activity levels. In pancreatitis patients, significant associations were found for FUT-2 non-secretor status (OR=1.53; p=8.56x10-4 ) and ABO -B (OR=1.69, p=1.0x10-4 ) with chronic pancreatitis, but not with acute pancreatitis. Conversely, carriers of blood group O were less frequently affected by chronic pancreatitis (OR=0.62; p=1.22x10-05) and less likely to have high lipase activity levels (OR=0.59; p=8.14x10-05 ). Conclusions These are the first results indicating that ABO blood type-B as well as FUT2 non-secretor status are common population-wide risk factors for developing chronic pancreatitis. They also imply that, even within the reference range, elevated lipase activities may indicate subclinical pancreatic injury in asymptomatic subjects. ObjectiveSerum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity-within the reference range and in the absence of pancreatitis-are associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also associated with clinical pancreatitis.MethodsGenome-wide association studies (GWAS) on phenotypes 'serum lipase activity' and 'high serum lipase activity' were conducted including 3966 German volunteers from the population-based Study-of-Health-in-Pomerania (SHIP). Lead SNPs associated on a genome-wide significance level were replicated in two cohorts, 1444 blood donors and 1042 pancreatitis patients.ResultsInitial discovery GWAS detected SNPs within or near genes encoding the ABO blood group specifying transferases A/B (ABO), Fucosyltransferase-2 (FUT2), and Chymotrypsinogen-B2 (CTRB2), to be significantly associated with lipase activity levels in asymptomatic subjects. Replication analyses in blood donors confirmed the association of FUT-2 non-secretor status (OR=1.49; p=0.012) and ABO blood-type-B (OR=2.48; p=7.2910-8) with high lipase activity levels. In pancreatitis patients, significant associations were found for FUT-2 non-secretor status (OR=1.53; p=8.5610-4) and ABO-B (OR=1.69, p=1.010-4) with chronic pancreatitis, but not with acute pancreatitis. Conversely, carriers of blood group O were less frequently affected by chronic pancreatitis (OR=0.62; p=1.2210-05) and less likely to have high lipase activity levels (OR=0.59; p=8.1410-05).ConclusionsThese are the first results indicating that ABO blood type-B as well as FUT2 non-secretor status are common population-wide risk factors for developing chronic pancreatitis. They also imply that, even within the reference range, elevated lipase activities may indicate subclinical pancreatic injury in asymptomatic subjects. Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity-within the reference range and in the absence of pancreatitis-are associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also associated with clinical pancreatitis.OBJECTIVESerum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity-within the reference range and in the absence of pancreatitis-are associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also associated with clinical pancreatitis.Genome-wide association studies (GWAS) on phenotypes 'serum lipase activity' and 'high serum lipase activity' were conducted including 3966 German volunteers from the population-based Study-of-Health-in-Pomerania (SHIP). Lead SNPs associated on a genome-wide significance level were replicated in two cohorts, 1444 blood donors and 1042 pancreatitis patients.METHODSGenome-wide association studies (GWAS) on phenotypes 'serum lipase activity' and 'high serum lipase activity' were conducted including 3966 German volunteers from the population-based Study-of-Health-in-Pomerania (SHIP). Lead SNPs associated on a genome-wide significance level were replicated in two cohorts, 1444 blood donors and 1042 pancreatitis patients.Initial discovery GWAS detected SNPs within or near genes encoding the ABO blood group specifying transferases A/B (ABO), Fucosyltransferase-2 (FUT2), and Chymotrypsinogen-B2 (CTRB2), to be significantly associated with lipase activity levels in asymptomatic subjects. Replication analyses in blood donors confirmed the association of FUT-2 non-secretor status (OR=1.49; p=0.012) and ABO blood-type-B (OR=2.48; p=7.29×10(-8)) with high lipase activity levels. In pancreatitis patients, significant associations were found for FUT-2 non-secretor status (OR=1.53; p=8.56×10(-4)) and ABO-B (OR=1.69, p=1.0×10(-4)) with chronic pancreatitis, but not with acute pancreatitis. Conversely, carriers of blood group O were less frequently affected by chronic pancreatitis (OR=0.62; p=1.22×10(-05)) and less likely to have high lipase activity levels (OR=0.59; p=8.14×10(-05)).RESULTSInitial discovery GWAS detected SNPs within or near genes encoding the ABO blood group specifying transferases A/B (ABO), Fucosyltransferase-2 (FUT2), and Chymotrypsinogen-B2 (CTRB2), to be significantly associated with lipase activity levels in asymptomatic subjects. Replication analyses in blood donors confirmed the association of FUT-2 non-secretor status (OR=1.49; p=0.012) and ABO blood-type-B (OR=2.48; p=7.29×10(-8)) with high lipase activity levels. In pancreatitis patients, significant associations were found for FUT-2 non-secretor status (OR=1.53; p=8.56×10(-4)) and ABO-B (OR=1.69, p=1.0×10(-4)) with chronic pancreatitis, but not with acute pancreatitis. Conversely, carriers of blood group O were less frequently affected by chronic pancreatitis (OR=0.62; p=1.22×10(-05)) and less likely to have high lipase activity levels (OR=0.59; p=8.14×10(-05)).These are the first results indicating that ABO blood type-B as well as FUT2 non-secretor status are common population-wide risk factors for developing chronic pancreatitis. They also imply that, even within the reference range, elevated lipase activities may indicate subclinical pancreatic injury in asymptomatic subjects.CONCLUSIONSThese are the first results indicating that ABO blood type-B as well as FUT2 non-secretor status are common population-wide risk factors for developing chronic pancreatitis. They also imply that, even within the reference range, elevated lipase activities may indicate subclinical pancreatic injury in asymptomatic subjects. Objective Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity—within the reference range and in the absence of pancreatitis—are associated with genetic single nucleotide polymorphisms (SNP), and whether these identified SNPs are also associated with clinical pancreatitis. Methods Genome-wide association studies (GWAS) on phenotypes ‘serum lipase activity’ and ‘high serum lipase activity’ were conducted including 3966 German volunteers from the population-based Study-of-Health-in-Pomerania (SHIP). Lead SNPs associated on a genome-wide significance level were replicated in two cohorts, 1444 blood donors and 1042 pancreatitis patients. Results Initial discovery GWAS detected SNPs within or near genes encoding the ABO blood group specifying transferases A/B (ABO), Fucosyltransferase-2 (FUT2), and Chymotrypsinogen-B2 (CTRB2), to be significantly associated with lipase activity levels in asymptomatic subjects. Replication analyses in blood donors confirmed the association of FUT-2 non-secretor status (OR=1.49; p=0.012) and ABO blood-type-B (OR=2.48; p=7.29×10−8) with high lipase activity levels. In pancreatitis patients, significant associations were found for FUT-2 non-secretor status (OR=1.53; p=8.56×10−4) and ABO-B (OR=1.69, p=1.0×10−4) with chronic pancreatitis, but not with acute pancreatitis. Conversely, carriers of blood group O were less frequently affected by chronic pancreatitis (OR=0.62; p=1.22×10−05) and less likely to have high lipase activity levels (OR=0.59; p=8.14×10−05). Conclusions These are the first results indicating that ABO blood type-B as well as FUT2 non-secretor status are common population-wide risk factors for developing chronic pancreatitis. They also imply that, even within the reference range, elevated lipase activities may indicate subclinical pancreatic injury in asymptomatic subjects.
Author	Radke, Dörte Völzke, Henry Greinacher, Andreas Ernst, Florian Weiss, Frank Ulrich Teumer, Alexander Zenker, Martin Lerch, Markus M Mayerle, Julia Schurmann, Claudia Kuehn, Jens-Peter Guenther, Annett Homuth, Georg Simon, Peter Völker, Uwe
Author_xml	– sequence: 1 givenname: Frank Ulrich surname: Weiss fullname: Weiss, Frank Ulrich organization: Department of Medicine A, University Medicine Greifswald, Greifswald, Germany – sequence: 2 givenname: Claudia surname: Schurmann fullname: Schurmann, Claudia organization: The Charles Bronfman Institute for Personalized Medicine, Genetics of Obesity & Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, USA – sequence: 3 givenname: Annett surname: Guenther fullname: Guenther, Annett organization: Department of Medicine A, University Medicine Greifswald, Greifswald, Germany – sequence: 4 givenname: Florian surname: Ernst fullname: Ernst, Florian organization: Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany – sequence: 5 givenname: Alexander surname: Teumer fullname: Teumer, Alexander organization: Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany – sequence: 6 givenname: Julia surname: Mayerle fullname: Mayerle, Julia organization: Department of Medicine A, University Medicine Greifswald, Greifswald, Germany – sequence: 7 givenname: Peter surname: Simon fullname: Simon, Peter organization: Department of Medicine A, University Medicine Greifswald, Greifswald, Germany – sequence: 8 givenname: Henry surname: Völzke fullname: Völzke, Henry organization: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany – sequence: 9 givenname: Dörte surname: Radke fullname: Radke, Dörte organization: Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany – sequence: 10 givenname: Andreas surname: Greinacher fullname: Greinacher, Andreas organization: Department of Transfusion Medicine, Institute of Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany – sequence: 11 givenname: Jens-Peter surname: Kuehn fullname: Kuehn, Jens-Peter organization: Department of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany – sequence: 12 givenname: Martin surname: Zenker fullname: Zenker, Martin organization: Institute of Human Genetics, Otto-von-Guericke-Universität Magdeburg, University Hospital Magdeburg, Germany – sequence: 13 givenname: Uwe surname: Völker fullname: Völker, Uwe organization: Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany – sequence: 14 givenname: Georg surname: Homuth fullname: Homuth, Georg organization: Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany – sequence: 15 givenname: Markus M surname: Lerch fullname: Lerch, Markus M organization: Department of Medicine A, University Medicine Greifswald, Greifswald, Germany
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25028398$$D View this record in MEDLINE/PubMed
BookMark	eNqNks1u1DAUhS1URKeFF2CBLLFpJQL-STI2O6g6gFSJTbu2HOdm6iGxg3-K5lV5GjwznU0XwMqy_J1zr-89Z-jEeQcIvabkPaW8_bDOaePGihFaV5y0kpNnaEHrVlScCXGCFoTQZdUsa3mKzmLcEEKEkPQFOmUNYYJLsUC_V9n4uB1T0C4OEHQEzPDF6u6WXeJSr4pgAiQfcEw65Yi163E3et_jdfB5xp-xDoB1jN5YnaDHv2y6xzDCw_4WIeQJj3beGWuT7INNW2xdUWynOflJJ2twzN0GTIrv9vbaFaBULZIeBxt_4KHUN_fBu8LOev-WbLLxI9Z4DQ52HscWrHel19xvX6Lngx4jvHo8z9Hd6vr26mt18_3Lt6tPN1VX8yZVXVOTnrNBEt6woatbw40khkNT64FIKK-6gMww6AUFJiUFgGagtTDQtQM_RxcH3zn4nxliUpONBsZRO_A5KiqIaOmyDP_faNsyQngtWUHfPkE3PgdXPqLocinrtuGMFOrNI5W7CXo1BzvpsFXHBRdAHAATfIwBBmVs2g-pbNyOihK1y5I6ZEntsqQOWSpS9kR6dP-rqDqIumnzP_wf_tbgxg
CODEN	GUTTAK
CitedBy_id	crossref_primary_10_1183_13993003_01667_2022 crossref_primary_10_1159_000499138 crossref_primary_10_1016_j_pan_2016_05_394 crossref_primary_10_1136_gutjnl_2016_313138 crossref_primary_10_1136_gutjnl_2020_320723 crossref_primary_10_1093_glycob_cww086 crossref_primary_10_1093_jpids_piy085 crossref_primary_10_5021_ad_2018_30_3_364 crossref_primary_10_1097_TP_0000000000004563 crossref_primary_10_1159_000445233 crossref_primary_10_1016_j_pan_2015_05_476 crossref_primary_10_1097_MOL_0000000000000866 crossref_primary_10_1016_j_pan_2017_09_007 crossref_primary_10_1053_j_gastro_2018_11_081 crossref_primary_10_1007_s11938_022_00383_0 crossref_primary_10_1136_gutjnl_2020_322864 crossref_primary_10_1016_j_bbagen_2015_12_026 crossref_primary_10_1111_trf_17002 crossref_primary_10_1016_j_pan_2024_12_016 crossref_primary_10_1136_gutjnl_2015_309682 crossref_primary_10_1053_j_gastro_2015_07_057 crossref_primary_10_31146_1682_8658_ecg_193_9_27_32 crossref_primary_10_1136_gutjnl_2015_309521 crossref_primary_10_1002_2211_5463_12278 crossref_primary_10_1007_s00018_019_03254_7 crossref_primary_10_1038_s41372_020_00870_1 crossref_primary_10_1038_s41588_020_00747_1 crossref_primary_10_1097_MOG_0000000000000293 crossref_primary_10_1016_j_pan_2025_07_407 crossref_primary_10_1038_ctg_2016_26 crossref_primary_10_1097_MPA_0000000000000713 crossref_primary_10_1097_MPA_0000000000001329 crossref_primary_10_1159_000508173 crossref_primary_10_1016_j_jcmgh_2017_05_007 crossref_primary_10_1097_MPA_0000000000001970 crossref_primary_10_1016_j_gendis_2025_101570 crossref_primary_10_15789_2220_7619_EAA_1586 crossref_primary_10_14309_ctg_0000000000000027 crossref_primary_10_1002_ijc_31047 crossref_primary_10_1016_j_abb_2020_108653 crossref_primary_10_1080_14728222_2019_1667977 crossref_primary_10_1097_MOG_0000000000000461 crossref_primary_10_1038_s41598_024_60312_2 crossref_primary_10_1016_j_pan_2016_10_006 crossref_primary_10_1007_s11377_025_00921_z crossref_primary_10_1002_hep_30313 crossref_primary_10_1038_ng_3249 crossref_primary_10_3390_nu7085314 crossref_primary_10_1002_wsbm_1413 crossref_primary_10_1038_s41586_023_06893_w crossref_primary_10_1074_jbc_RA118_001934 crossref_primary_10_3390_cancers11091241 crossref_primary_10_1038_s41591_024_03010_w crossref_primary_10_3389_fmed_2023_1070734 crossref_primary_10_1055_a_1735_3864 crossref_primary_10_1136_gutjnl_2016_313127 crossref_primary_10_1007_s11298_022_2396_9 crossref_primary_10_1097_MCG_0000000000000688 crossref_primary_10_31146_1682_8658_ecg_197_1_18_23 crossref_primary_10_1016_j_pan_2018_04_007 crossref_primary_10_1111_acer_14405 crossref_primary_10_1186_s13059_021_02562_1 crossref_primary_10_1016_j_tim_2017_09_011 crossref_primary_10_3390_diagnostics13030369 crossref_primary_10_1186_s12879_023_08496_2
Cites_doi	10.1001/jama.286.2.169 10.1111/j.1423-0410.1995.tb02591.x 10.1016/S0399-8320(06)73330-9 10.1002/gepi.20303 10.1093/jnci/djp020 10.1093/hmg/ddq248 10.1159/000200881 10.1111/j.1423-0410.1989.tb03040.x 10.1016/S0140-6736(10)61996-4 10.1172/JCI115091 10.7326/0003-4819-150-9-200905050-00006 10.1158/0008-5472.CAN-09-2993 10.1053/j.gastro.2012.12.043 10.1371/journal.pone.0020113 10.1159/000055840 10.1002/ijc.25426 10.1111/j.1537-2995.2006.00975.x 10.1136/gut.35.3.401 10.1093/glycob/cws084 10.1182/blood.V69.6.1691.1691 10.1038/ng.429 10.1111/j.1572-0241.2000.03279.x 10.1097/MPA.0b013e31817f527d 10.1074/jbc.270.9.4640 10.1097/00006676-200003000-00008 10.1186/1471-2407-12-319 10.1136/gut.2009.192492 10.1093/ije/dyp394 10.1016/j.ajhg.2011.04.015 10.1097/MPA.0b013e3182232975 10.1056/NEJM199305203282001 10.1016/S0021-9258(19)50338-6 10.1016/j.jinf.2012.05.011 10.1016/S0002-9343(01)00958-5 10.1158/1055-9965.EPI-10-0751 10.1016/0140-6736(93)90942-A 10.1038/ng.2500 10.1136/bmj.2.4883.315 10.1038/ncpgasthep0293 10.1111/j.1349-7006.2011.01907.x
ContentType	Journal Article
Copyright	Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
Copyright_xml	– notice: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions – notice: Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. – notice: Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 88I 8AF 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI BTHHO CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 7T5 H94
DOI	10.1136/gutjnl-2014-306930
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Science Database (Alumni Edition) STEM Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection BMJ Journals ProQuest One Community College ProQuest Central ProQuest Health & Medical Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic Immunology Abstracts AIDS and Cancer Research Abstracts
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest AP Science ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition BMJ Journals ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic AIDS and Cancer Research Abstracts Immunology Abstracts
DatabaseTitleList	MEDLINE ProQuest Central Student AIDS and Cancer Research Abstracts MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1468-3288
EndPage	656
ExternalDocumentID	4014717821 25028398 10_1136_gutjnl_2014_306930 gutjnl
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- .55 .GJ .VT 08G 0R~ 18M 29I 2WC 354 39C 3O- 4.4 40O 53G 5GY 5VS 7X7 7~S 88E 88I 8AF 8F7 8FE 8FH 8FI 8FJ 8R4 8R5 AAHLL AAKAS AAOJX AAUVZ AAWJN AAYEP ABAAH ABKDF ABMQD ABOCM ABTFR ABUWG ABVAJ ACGFO ACGFS ACGOD ACGTL ACHTP ACMFJ ACOAB ACOFX ACQSR ACTZY ADBBV ADCEG ADFRT ADUGQ ADZCM AENEX AFKRA AFWFF AGQPQ AHMBA AHNKE AHQMW AI. AJYBZ ALIPV ALMA_UNASSIGNED_HOLDINGS ASPBG AVWKF AZFZN AZQEC BAWUL BBNVY BENPR BHPHI BLJBA BOMFT BPHCQ BTFSW BTHHO BVXVI C1A C45 CAG CCPQU COF CS3 CXRWF DIK DU5 DWQXO E3Z EBS EJD F5P FD8 FEDTE FYUFA GNUQQ GX1 H13 HAJ HCIFZ HMCUK HVGLF HYE HZ~ IAO IEA IH2 IHR INH INR IOF ITC J5H KQ8 L7B LK8 M1P M2P M7P N9A NTWIH NXWIF O9- OK1 OVD P2P PHGZT PQQKQ PROAC PSQYO Q2X R53 RHI RMJ RPM RV8 TEORI TR2 UKHRP UYXKK V24 VH1 VM9 VVN W8F WH7 WOQ X7M YFH YOC YQY ZGI ZXP ZY1 AAYXX ACQHZ AERUA AFFHD CITATION PHGZM PJZUB PPXIY PQGLB ADGHP CGR CUY CVF ECM EIF NPM 3V. 7XB 8FK K9. PKEHL PQEST PQUKI PRINS Q9U 7X8 7T5 H94 PUEGO
ID	FETCH-LOGICAL-b435t-b540d32f90352fb46c3c90c3e54af09e40da4352c2ed81e2991eee5f148ceb6f3
IEDL.DBID	M7P
ISICitedReferencesCount	67
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000350800100020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0017-5749 1468-3288
IngestDate	Fri Sep 05 08:19:27 EDT 2025 Sun Nov 09 12:00:15 EST 2025 Tue Oct 07 07:24:43 EDT 2025 Mon Jul 21 05:45:39 EDT 2025 Tue Nov 18 22:42:29 EST 2025 Sat Nov 29 05:41:54 EST 2025 Thu Apr 24 23:07:02 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Issue	4
Keywords	Pancreatic Enzymes Chronic Pancreatitis Linkage Analysis Glycosyltransferases Genetic Polymorphisms
Language	English
License	Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-b435t-b540d32f90352fb46c3c90c3e54af09e40da4352c2ed81e2991eee5f148ceb6f3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
PMID	25028398
PQID	1779465320
PQPubID	2041069
PageCount	11
ParticipantIDs	proquest_miscellaneous_1808617008 proquest_miscellaneous_1662003492 proquest_journals_1779465320 pubmed_primary_25028398 crossref_citationtrail_10_1136_gutjnl_2014_306930 crossref_primary_10_1136_gutjnl_2014_306930 bmj_primary_10_1136_gutjnl_2014_306930
PublicationCentury	2000
PublicationDate	2015-04-01
PublicationDateYYYYMMDD	2015-04-01
PublicationDate_xml	– month: 04 year: 2015 text: 2015-04-01 day: 01
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England – name: London
PublicationTitle	Gut
PublicationTitleAlternate	Gut
PublicationYear	2015
Publisher	BMJ Publishing Group LTD
Publisher_xml	– name: BMJ Publishing Group LTD
References	Wolpin, Kraft, Gross 2010; 70 Jenkins, O'Donnell 2006; 46 Volzke, Luedemann, Mayerle 2008; 37 Gill, Endres-Brooks, Bauer 1987; 69 Agarwal, Pitchumoni, Sivaprasad 1990; 85 Amundadottir, Kraft, Stolzenberg-Solomon 2009; 41 Teumer, Rawal, Homuth 2011; 88 Ichihara, Sato, Kozuka 1992; 51 Lerch, Gorelick 2013; 144 McGovern, Jones, Taylor 2010; 19 Hirano, Saluja, Ramarao 1991; 87 Ben, Wang, Yuan 2011; 128 Mayerle, Hlouschek, Lerch 2005; 2 Matsui, Titani, Mizuochi 1992; 267 Rahbari, Bork, Hinz 2012; 12 Reilly, Li, He 2011; 377 Aird, Bentall, Mehigan 1954; 2 Gress, Muller-Pillasch, Lerch 1994; 32 Ellis, Lerch, Whitcomb 2001; 1 Wacklin, Mäkivuokko, Alakulppi 2011; 6 Levy, Barthet, Mollard 2006; 30 Nakao, Matsuo, Hosono 2011; 102 Nurjadi, Lependu, Kremsner 2012; 65 Wolpin, Kraft, Xu 2010; 19 Gullo 2000; 20 Yadav, Nair, Norkus 2000; 95 Völzke, Alte, Schmidt 2011; 40 Olsen 1978; 86A 2013; 13 Wolpin, Chan, Hartge 2009; 101 Pe'er, Yelensky, Altshuler 2008; 32 Lerch, Hoppe-Seyler, Gerok 1994; 35 Köttgen, Albrecht, Teumer 2013; 45 Levey, Stevens, Schmid 2009; 150 Clausen, Hakomori 1989; 56 Henry, Oriol, Samuelsson 1995; 69 Hernandez, Lerch 1993; 341 Nasir, Frank, Koppisetty 2012; 22 Kelly, Rouquier, Giorgi 1995; 270 Lowenfels, Maisonneuve, Cavallini 1993; 328 Guenther, Aghdassi, Muddana; 59 Lowenfels, Maisonneuve, Whitcomb 2001; 286 Greer, LaRusch, Brand 2011; 40 Keim, Bauer, Teich 2001; 111 Gullo (key-10.1136/gutjnl-2014-306930-11) 2000; 20 Nakao (key-10.1136/gutjnl-2014-306930-28) 2011; 102 Wolpin (key-10.1136/gutjnl-2014-306930-29) 2009; 101 Köttgen (key-10.1136/gutjnl-2014-306930-19) 2013; 45 Hirano (key-10.1136/gutjnl-2014-306930-2) 1991; 87 Lowenfels (key-10.1136/gutjnl-2014-306930-32) 2001; 286 Levy (key-10.1136/gutjnl-2014-306930-42) 2006; 30 Henry (key-10.1136/gutjnl-2014-306930-21) 1995; 69 Jenkins (key-10.1136/gutjnl-2014-306930-35) 2006; 46 Agarwal (key-10.1136/gutjnl-2014-306930-8) 1990; 85 Levey (key-10.1136/gutjnl-2014-306930-13) 2009; 150 Wacklin (key-10.1136/gutjnl-2014-306930-39) 2011; 6 Pe'er (key-10.1136/gutjnl-2014-306930-18) 2008; 32 Reilly (key-10.1136/gutjnl-2014-306930-24) 2011; 377 Aird (key-10.1136/gutjnl-2014-306930-23) 1954; 2 Keim (key-10.1136/gutjnl-2014-306930-15) 2001; 111 Greer (key-10.1136/gutjnl-2014-306930-41) 2011; 40 Ichihara (key-10.1136/gutjnl-2014-306930-43) 1992; 51 Working Group IAP/APA Acute Pancreatitis Guidelines (key-10.1136/gutjnl-2014-306930-1) 2013; 13 Ben (key-10.1136/gutjnl-2014-306930-26) 2011; 128 Wolpin (key-10.1136/gutjnl-2014-306930-37) 2010; 19 Gress (key-10.1136/gutjnl-2014-306930-7) 1994; 32 McGovern (key-10.1136/gutjnl-2014-306930-36) 2010; 19 Lerch (key-10.1136/gutjnl-2014-306930-3) 2013; 144 Rahbari (key-10.1136/gutjnl-2014-306930-27) 2012; 12 Nurjadi (key-10.1136/gutjnl-2014-306930-38) 2012; 65 Yadav (key-10.1136/gutjnl-2014-306930-10) 2000; 95 Völzke (key-10.1136/gutjnl-2014-306930-12) 2011; 40 Amundadottir (key-10.1136/gutjnl-2014-306930-25) 2009; 41 Olsen (key-10.1136/gutjnl-2014-306930-44) 1978; 86A Ellis (key-10.1136/gutjnl-2014-306930-16) 2001; 1 Gill (key-10.1136/gutjnl-2014-306930-33) 1987; 69 Nasir (key-10.1136/gutjnl-2014-306930-40) 2012; 22 Hernandez (key-10.1136/gutjnl-2014-306930-4) 1993; 341 Teumer (key-10.1136/gutjnl-2014-306930-17) 2011; 88 Kelly (key-10.1136/gutjnl-2014-306930-20) 1995; 270 Lowenfels (key-10.1136/gutjnl-2014-306930-31) 1993; 328 Mayerle (key-10.1136/gutjnl-2014-306930-5) 2005; 2 Wolpin (key-10.1136/gutjnl-2014-306930-30) 2010; 70 Lerch (key-10.1136/gutjnl-2014-306930-6) 1994; 35 Guenther (key-10.1136/gutjnl-2014-306930-14); 59 Matsui (key-10.1136/gutjnl-2014-306930-34) 1992; 267 Volzke (key-10.1136/gutjnl-2014-306930-9) 2008; 37 Clausen (key-10.1136/gutjnl-2014-306930-22) 1989; 56 27849560 - Gut. 2017 Aug;66(8):1531-1532
References_xml	– volume: 88 start-page: 664 year: 2011 article-title: Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk publication-title: Am J Hum Genet – volume: 270 start-page: 4640 year: 1995 article-title: Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype publication-title: J Biol Chem – volume: 101 start-page: 424 year: 2009 article-title: ABO blood group and the risk of pancreatic cancer publication-title: J Natl Cancer Inst – volume: 70 start-page: 1015 year: 2010 article-title: Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium publication-title: Cancer Res – volume: 19 start-page: 3468 year: 2010 article-title: Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease publication-title: Hum Mol Genet – volume: 128 start-page: 1179 year: 2011 article-title: Pancreatic cancer incidence and outcome in relation to ABO blood groups among Han Chinese patients: a case-control study publication-title: Int J Cancer – volume: 59 start-page: 1154 article-title: Toll-like receptor 4 polymorphisms in German and US patients are not associated with occurrence or severity of acute pancreatitis publication-title: Gut – volume: 328 start-page: 1433 year: 1993 article-title: Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group publication-title: N Engl J Med – volume: 267 start-page: 8723 year: 1992 article-title: Structures of the asparagine-linked oligosaccharide chains of human von Willebrand factor. Occurrence of blood group A, B, and H(O) structures publication-title: J Biol Chem – volume: 32 start-page: 381 year: 2008 article-title: Estimation of the multiple testing burden for genomewide association studies of nearly all common variants publication-title: Genet Epidemiol – volume: 95 start-page: 3123 year: 2000 article-title: Nonspecific hyperamylasemia and hyperlipasemia in diabetic ketoacidosis: incidence and correlation with biochemical abnormalities publication-title: Am J Gastroenterol – volume: 51 start-page: 86 year: 1992 article-title: Prevalence of pancreatitis in liver diseases of various etiologies: an analysis of 107,754 adult autopsies in Japan publication-title: Digestion – volume: 69 start-page: 1691 year: 1987 article-title: The effect of ABO blood group on the diagnosis of von Willebrand disease publication-title: Blood – volume: 30 start-page: 838 year: 2006 article-title: Estimation of the prevalence and incidence of chronic pancreatitis and its complications publication-title: Gastroenterol Clin Biol – volume: 37 start-page: 411 year: 2008 article-title: Prevalence and determinants of increased serum lipase levels in a general population publication-title: Pancreas – volume: 35 start-page: 401 year: 1994 article-title: Origin and development of exocrine pancreatic insufficiency in experimental renal failure publication-title: Gut – volume: 40 start-page: 294 year: 2011 article-title: Cohort profile: the study of health in Pomerania publication-title: Int J Epidemiol – volume: 341 start-page: 1371 year: 1993 article-title: Sphincter stenosis and gallstone migration through the biliary tract publication-title: Lancet – volume: 69 start-page: 166 year: 1995 article-title: Lewis histo-blood group system and associated secretory phenotypes publication-title: Vox Sang – volume: 2 start-page: 315 year: 1954 article-title: The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast, and bronchus; an association between the ABO groups and peptic ulceration publication-title: Br Med J – volume: 65 start-page: 310 year: 2012 article-title: Staphylococcus aureus throat carriage is associated with ABO-/secretor status publication-title: J Infect – volume: 87 start-page: 865 year: 1991 article-title: Apical secretion of lysosomal enzymes in rabbit pancreas occurs via a secretagogue regulated pathway and is increased after pancreatic duct obstruction publication-title: J Clin Invest – volume: 102 start-page: 1076 year: 2011 article-title: ABO blood group alleles and the risk of pancreatic cancer in a Japanese population publication-title: Cancer Sci – volume: 22 start-page: 1163 year: 2012 article-title: Lewis histo-blood group α1,3/α1,4 fucose residues may both mediate binding to GII.4 noroviruses publication-title: Glycobiology – volume: 286 start-page: 169 year: 2001 article-title: Cigarette smoking as a risk factor for pancreatic cancer in patients with hereditary pancreatitis publication-title: JAMA – volume: 150 start-page: 604 year: 2009 article-title: A new equation to estimate glomerular filtration rate publication-title: Ann Intern Med – volume: 45 start-page: 145 year: 2013 article-title: Genome-wide association analyses identify 18 new loci associated with serum urate concentrations publication-title: Nat Genet – volume: 19 start-page: 3140 year: 2010 article-title: Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium publication-title: Cancer Epidemiol Biomarkers Prev – volume: 56 start-page: 1 year: 1989 article-title: ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and their distribution publication-title: Vox Sang – volume: 20 start-page: 158 year: 2000 article-title: Familial pancreatic hyperenzymemia publication-title: Pancreas – volume: 86A start-page: 361 year: 1978 article-title: The incidence and clinical relevance of chronic inflammation in the pancreas in autopsy material publication-title: Acta Pathol Microbiol Scand A – volume: 1 start-page: 405 year: 2001 article-title: Genetic testing for hereditary pancreatitis: guidelines for indications, counselling, consent and privacy issues publication-title: Pancreatology – volume: 111 start-page: 622 year: 2001 article-title: Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene publication-title: Am J Med – volume: 32 start-page: 221 year: 1994 article-title: Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitis publication-title: Z Gastroenterol – volume: 377 start-page: 383 year: 2011 article-title: Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies publication-title: Lancet – volume: 144 start-page: 1180 year: 2013 article-title: Models of acute and chronic pancreatitis publication-title: Gastroenterology – volume: 41 start-page: 986 year: 2009 article-title: Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer publication-title: Nat Genet – volume: 40 start-page: 1188 year: 2011 article-title: ABO blood group and chronic pancreatitis risk in the NAPS2 cohort publication-title: Pancreas – volume: 2 start-page: 473 year: 2005 article-title: Current management of acute pancreatitis publication-title: Nat Clin Pract Gastroenterol Hepatol – volume: 6 start-page: e20113 year: 2011 article-title: Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine publication-title: PLoS ONE – volume: 12 start-page: 319 year: 2012 article-title: AB0 blood group and prognosis in patients with pancreatic cancer publication-title: BMC Cancer – volume: 85 start-page: 356 year: 1990 article-title: Evaluating tests for acute pancreatitis publication-title: Am J Gastroenterol – volume: 13 start-page: e1 issue: (4 Suppl 2) year: 2013 article-title: IAP/APA evidence-based guidelines for the management of acute pancreatitis publication-title: Pancreatology – volume: 46 start-page: 1836 year: 2006 article-title: ABO blood group determines plasma von Willebrand factor levels: a biologic function after all? publication-title: Transfusion – volume: 286 start-page: 169 year: 2001 ident: key-10.1136/gutjnl-2014-306930-32 article-title: Cigarette smoking as a risk factor for pancreatic cancer in patients with hereditary pancreatitis publication-title: JAMA doi: 10.1001/jama.286.2.169 – volume: 69 start-page: 166 year: 1995 ident: key-10.1136/gutjnl-2014-306930-21 article-title: Lewis histo-blood group system and associated secretory phenotypes publication-title: Vox Sang doi: 10.1111/j.1423-0410.1995.tb02591.x – volume: 30 start-page: 838 year: 2006 ident: key-10.1136/gutjnl-2014-306930-42 article-title: Estimation of the prevalence and incidence of chronic pancreatitis and its complications publication-title: Gastroenterol Clin Biol doi: 10.1016/S0399-8320(06)73330-9 – volume: 13 start-page: e1 issue: (4 Suppl 2) year: 2013 ident: key-10.1136/gutjnl-2014-306930-1 article-title: IAP/APA evidence-based guidelines for the management of acute pancreatitis publication-title: Pancreatology – volume: 32 start-page: 381 year: 2008 ident: key-10.1136/gutjnl-2014-306930-18 article-title: Estimation of the multiple testing burden for genomewide association studies of nearly all common variants publication-title: Genet Epidemiol doi: 10.1002/gepi.20303 – volume: 101 start-page: 424 year: 2009 ident: key-10.1136/gutjnl-2014-306930-29 article-title: ABO blood group and the risk of pancreatic cancer publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djp020 – volume: 19 start-page: 3468 year: 2010 ident: key-10.1136/gutjnl-2014-306930-36 article-title: Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease publication-title: Hum Mol Genet doi: 10.1093/hmg/ddq248 – volume: 32 start-page: 221 year: 1994 ident: key-10.1136/gutjnl-2014-306930-7 article-title: Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitis publication-title: Z Gastroenterol – volume: 51 start-page: 86 year: 1992 ident: key-10.1136/gutjnl-2014-306930-43 article-title: Prevalence of pancreatitis in liver diseases of various etiologies: an analysis of 107,754 adult autopsies in Japan publication-title: Digestion doi: 10.1159/000200881 – volume: 56 start-page: 1 year: 1989 ident: key-10.1136/gutjnl-2014-306930-22 article-title: ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and their distribution publication-title: Vox Sang doi: 10.1111/j.1423-0410.1989.tb03040.x – volume: 377 start-page: 383 year: 2011 ident: key-10.1136/gutjnl-2014-306930-24 article-title: Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies publication-title: Lancet doi: 10.1016/S0140-6736(10)61996-4 – volume: 87 start-page: 865 year: 1991 ident: key-10.1136/gutjnl-2014-306930-2 article-title: Apical secretion of lysosomal enzymes in rabbit pancreas occurs via a secretagogue regulated pathway and is increased after pancreatic duct obstruction publication-title: J Clin Invest doi: 10.1172/JCI115091 – volume: 150 start-page: 604 year: 2009 ident: key-10.1136/gutjnl-2014-306930-13 article-title: A new equation to estimate glomerular filtration rate publication-title: Ann Intern Med doi: 10.7326/0003-4819-150-9-200905050-00006 – volume: 70 start-page: 1015 year: 2010 ident: key-10.1136/gutjnl-2014-306930-30 article-title: Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-09-2993 – volume: 144 start-page: 1180 year: 2013 ident: key-10.1136/gutjnl-2014-306930-3 article-title: Models of acute and chronic pancreatitis publication-title: Gastroenterology doi: 10.1053/j.gastro.2012.12.043 – volume: 6 start-page: e20113 year: 2011 ident: key-10.1136/gutjnl-2014-306930-39 article-title: Secretor genotype (FUT2 gene) is strongly associated with the composition of Bifidobacteria in the human intestine publication-title: PLoS ONE doi: 10.1371/journal.pone.0020113 – volume: 1 start-page: 405 year: 2001 ident: key-10.1136/gutjnl-2014-306930-16 article-title: Genetic testing for hereditary pancreatitis: guidelines for indications, counselling, consent and privacy issues publication-title: Pancreatology doi: 10.1159/000055840 – volume: 85 start-page: 356 year: 1990 ident: key-10.1136/gutjnl-2014-306930-8 article-title: Evaluating tests for acute pancreatitis publication-title: Am J Gastroenterol – volume: 128 start-page: 1179 year: 2011 ident: key-10.1136/gutjnl-2014-306930-26 article-title: Pancreatic cancer incidence and outcome in relation to ABO blood groups among Han Chinese patients: a case-control study publication-title: Int J Cancer doi: 10.1002/ijc.25426 – volume: 46 start-page: 1836 year: 2006 ident: key-10.1136/gutjnl-2014-306930-35 article-title: ABO blood group determines plasma von Willebrand factor levels: a biologic function after all? publication-title: Transfusion doi: 10.1111/j.1537-2995.2006.00975.x – volume: 35 start-page: 401 year: 1994 ident: key-10.1136/gutjnl-2014-306930-6 article-title: Origin and development of exocrine pancreatic insufficiency in experimental renal failure publication-title: Gut doi: 10.1136/gut.35.3.401 – volume: 22 start-page: 1163 year: 2012 ident: key-10.1136/gutjnl-2014-306930-40 article-title: Lewis histo-blood group α1,3/α1,4 fucose residues may both mediate binding to GII.4 noroviruses publication-title: Glycobiology doi: 10.1093/glycob/cws084 – volume: 69 start-page: 1691 year: 1987 ident: key-10.1136/gutjnl-2014-306930-33 article-title: The effect of ABO blood group on the diagnosis of von Willebrand disease publication-title: Blood doi: 10.1182/blood.V69.6.1691.1691 – volume: 41 start-page: 986 year: 2009 ident: key-10.1136/gutjnl-2014-306930-25 article-title: Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer publication-title: Nat Genet doi: 10.1038/ng.429 – volume: 95 start-page: 3123 year: 2000 ident: key-10.1136/gutjnl-2014-306930-10 article-title: Nonspecific hyperamylasemia and hyperlipasemia in diabetic ketoacidosis: incidence and correlation with biochemical abnormalities publication-title: Am J Gastroenterol doi: 10.1111/j.1572-0241.2000.03279.x – volume: 37 start-page: 411 year: 2008 ident: key-10.1136/gutjnl-2014-306930-9 article-title: Prevalence and determinants of increased serum lipase levels in a general population publication-title: Pancreas doi: 10.1097/MPA.0b013e31817f527d – volume: 270 start-page: 4640 year: 1995 ident: key-10.1136/gutjnl-2014-306930-20 article-title: Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype publication-title: J Biol Chem doi: 10.1074/jbc.270.9.4640 – volume: 20 start-page: 158 year: 2000 ident: key-10.1136/gutjnl-2014-306930-11 article-title: Familial pancreatic hyperenzymemia publication-title: Pancreas doi: 10.1097/00006676-200003000-00008 – volume: 12 start-page: 319 year: 2012 ident: key-10.1136/gutjnl-2014-306930-27 article-title: AB0 blood group and prognosis in patients with pancreatic cancer publication-title: BMC Cancer doi: 10.1186/1471-2407-12-319 – volume: 59 start-page: 1154 ident: key-10.1136/gutjnl-2014-306930-14 article-title: Toll-like receptor 4 polymorphisms in German and US patients are not associated with occurrence or severity of acute pancreatitis publication-title: Gut doi: 10.1136/gut.2009.192492 – volume: 40 start-page: 294 year: 2011 ident: key-10.1136/gutjnl-2014-306930-12 article-title: Cohort profile: the study of health in Pomerania publication-title: Int J Epidemiol doi: 10.1093/ije/dyp394 – volume: 88 start-page: 664 year: 2011 ident: key-10.1136/gutjnl-2014-306930-17 article-title: Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk publication-title: Am J Hum Genet doi: 10.1016/j.ajhg.2011.04.015 – volume: 40 start-page: 1188 year: 2011 ident: key-10.1136/gutjnl-2014-306930-41 article-title: ABO blood group and chronic pancreatitis risk in the NAPS2 cohort publication-title: Pancreas doi: 10.1097/MPA.0b013e3182232975 – volume: 328 start-page: 1433 year: 1993 ident: key-10.1136/gutjnl-2014-306930-31 article-title: Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group publication-title: N Engl J Med doi: 10.1056/NEJM199305203282001 – volume: 267 start-page: 8723 year: 1992 ident: key-10.1136/gutjnl-2014-306930-34 article-title: Structures of the asparagine-linked oligosaccharide chains of human von Willebrand factor. Occurrence of blood group A, B, and H(O) structures publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)50338-6 – volume: 65 start-page: 310 year: 2012 ident: key-10.1136/gutjnl-2014-306930-38 article-title: Staphylococcus aureus throat carriage is associated with ABO-/secretor status publication-title: J Infect doi: 10.1016/j.jinf.2012.05.011 – volume: 111 start-page: 622 year: 2001 ident: key-10.1136/gutjnl-2014-306930-15 article-title: Clinical characterization of patients with hereditary pancreatitis and mutations in the cationic trypsinogen gene publication-title: Am J Med doi: 10.1016/S0002-9343(01)00958-5 – volume: 19 start-page: 3140 year: 2010 ident: key-10.1136/gutjnl-2014-306930-37 article-title: Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium publication-title: Cancer Epidemiol Biomarkers Prev doi: 10.1158/1055-9965.EPI-10-0751 – volume: 341 start-page: 1371 year: 1993 ident: key-10.1136/gutjnl-2014-306930-4 article-title: Sphincter stenosis and gallstone migration through the biliary tract publication-title: Lancet doi: 10.1016/0140-6736(93)90942-A – volume: 86A start-page: 361 year: 1978 ident: key-10.1136/gutjnl-2014-306930-44 article-title: The incidence and clinical relevance of chronic inflammation in the pancreas in autopsy material publication-title: Acta Pathol Microbiol Scand A – volume: 45 start-page: 145 year: 2013 ident: key-10.1136/gutjnl-2014-306930-19 article-title: Genome-wide association analyses identify 18 new loci associated with serum urate concentrations publication-title: Nat Genet doi: 10.1038/ng.2500 – volume: 2 start-page: 315 year: 1954 ident: key-10.1136/gutjnl-2014-306930-23 article-title: The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast, and bronchus; an association between the ABO groups and peptic ulceration publication-title: Br Med J doi: 10.1136/bmj.2.4883.315 – volume: 2 start-page: 473 year: 2005 ident: key-10.1136/gutjnl-2014-306930-5 article-title: Current management of acute pancreatitis publication-title: Nat Clin Pract Gastroenterol Hepatol doi: 10.1038/ncpgasthep0293 – volume: 102 start-page: 1076 year: 2011 ident: key-10.1136/gutjnl-2014-306930-28 article-title: ABO blood group alleles and the risk of pancreatic cancer in a Japanese population publication-title: Cancer Sci doi: 10.1111/j.1349-7006.2011.01907.x – reference: 27849560 - Gut. 2017 Aug;66(8):1531-1532
SSID	ssj0008891
Score	2.4191194
Snippet	Objective Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity—within... Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity-within the... Objective Serum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity-within... ObjectiveSerum lipase activities above the threefold upper reference limit indicate acute pancreatitis. We investigated whether high lipase activity-within the...
SourceID	proquest pubmed crossref bmj
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	646
SubjectTerms	ABO Blood-Group System - physiology Adult Aged Aged, 80 and over Antigens Blood groups Consent Enzymes Female Fucosyltransferases - physiology Galactoside 2-alpha-L-fucosyltransferase Genetic Association Studies Genome-Wide Association Study Genomes Humans Lipase - blood Male Middle Aged Oils & fats Pancreatic cancer Pancreatitis, Chronic - epidemiology Pancreatitis, Chronic - genetics Polymorphism, Single Nucleotide Population Risk Assessment Rodents Studies Young Adult
Title	Fucosyltransferase 2 (FUT2) non-secretor status and blood group B are associated with elevated serum lipase activity in asymptomatic subjects, and an increased risk for chronic pancreatitis: a genetic association study
URI	http://gut.bmj.com/content/64/4/646.full https://www.ncbi.nlm.nih.gov/pubmed/25028398 https://www.proquest.com/docview/1779465320 https://www.proquest.com/docview/1662003492 https://www.proquest.com/docview/1808617008
Volume	64
WOSCitedRecordID	wos000350800100020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1468-3288 dateEnd: 20250607 omitProxy: false ssIdentifier: ssj0008891 issn: 0017-5749 databaseCode: M7P dateStart: 19600301 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1468-3288 dateEnd: 20250607 omitProxy: false ssIdentifier: ssj0008891 issn: 0017-5749 databaseCode: 7X7 dateStart: 19600301 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1468-3288 dateEnd: 20250607 omitProxy: false ssIdentifier: ssj0008891 issn: 0017-5749 databaseCode: BENPR dateStart: 19600301 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1468-3288 dateEnd: 20250607 omitProxy: false ssIdentifier: ssj0008891 issn: 0017-5749 databaseCode: M2P dateStart: 19600301 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bi9NAFB7cXZF98a5bXcsRRBQN20xuE1_ElS0-uKXIrvQtzFW6tGltEmH_qr_GcyZJxQeL4EshZGZ6yHxz5jsz58LYC7SLRwKJQ2Ckc0EcZzYQqUmCyDilZaIU91HvXz9nk4mYzfJpd-BWdW6VvU70itqsNJ2Rn4QZpUKnMgbv198DqhpFt6tdCY09dkBZEiLvujfdamLRV8xDTZxkcd4HzUTpybemvioXiJGQLgaoHiBuLmp59ef29BfO6fee8Z3_lfouu92xTvjQwuQeu2HL--zWeXev_oD9HJPj-vWi9jTWbnBrAw6vxpcX_DWUqzKoiF2ieQ4UgNRUIEsD3ucdfFgInILcWJDdXFsDdL4LFLvunxDnzRIW8zUNTKEUVLEC5iX2uF6u65XPGwtVo-hUqHrrh5clNiBOW-EA5AEPyK9Bt8l8AZVYy3frefUOJOA6oHDMrQgIN_Cpcx-yy_HZxcdPQVf1IVBI3epAIYc0EXc5ZWp1Kk51pPORjmwSSzfKLb6V2JBrbo0ILW6nobU2cWjXaatSFz1i-_hh7BGDkVE855kVLkWrycQidyZ2WWy0yIVR-YC9xCkv1m1ej8LbQ1FatNgoCBtFi40BC3tUFLrLnU4lPBY7-7zZ9vmXfzjuAVR0WqQqfqNnwJ5vX-P6p0sdWdpVg23SlPskQ3xHG4GGKyViFAP2uAXyViSkwMgwc_FktwBP2SFKm7Q-S8dsv9409hm7qX_gLG-GbC-bZf5XDNnB6dlk-gWfzvl06BfkL7I7PT8
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VgoAL70egwCABKmqtJuvXGgkhXlGrplEPKerNeF8oVeKE2AblT_GD-DXMrO0gDkRceuBoeXe9Wn8z-83uPBh7hnZxVyBx8HRmrRcEsfFEpEPP11aqLJSSu6j3T4N4OBSnp8nxBvvRxsKQW2WrE52i1jNFZ-R7vZhSoVMZgzfzrx5VjaLb1baERg2LQ7P8jiZb8frgA_7f55z3P47e73tNVQFPIjUoPYkcRfvcJpQJ1MogUr5Kuso3YZDZbmLwbYYNueJGi55Bdd0zxoQW7QZlZGR9HPcCu4g0ggvnKni80vyirdCHmj-Mg6QN0vGjvS9VeZZPEJM9uoig-oO4mcnp2Z_b4V84rtvr-tf_t1W6wa41rBre1mJwk22Y_Ba7fNT4DdxmP_vkmL-clI6mmwVu3cBhu38y4i8hn-VeQey5nC2AAqyqArJcg_PpBxf2Au8gWxjIGiwbDXR-DRSb755QjqspTMZzGphCRagiB4xz7LGczsuZy4sLRSXp1KvYdcNnOTYgzl7gAOThD2g_gKqTFQMq6ZrPl-PiFWSAck7hpqspoDiBSw18h52cy8reZZu4MOY-g66WPOGxETZCq1AHIrE6sHGglUiElkmHvUCIpfM6b0nq7D0_SmsspoTFtMZih_VaFKaqyQ1PJUoma_vsrPr8yxe2WsCmjZYs0t9o7bCnq9eo3-jSKsvNrMI2UcRdEiW-po1Aw5wSTYoOu1cLzmpKSPGRQSfiwfoJPGFX9kdHg3RwMDx8yK7izMPaP2uLbZaLyjxil9Q3_OOLx07kgX0-b-n5BdkxlpE
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VgiouvB-BAoMECARW4vVrjYQQUCKqliiHFvVmvC-UKnFCbIPy1_gp_Bpm1nYQByIuPXCMvN6s1vP4ZnfmG8YeYVw8EAgcPJ1b64VhYjwR68gLtJUqj6Tkrur902EyGomTk3S8xX50tTCUVtnZRGeo9VzRGXnfT4gKndoY9G2bFjHeG75efPWogxTdtHbtNBoROTCr7xi-la_29_BbP-Z8-P7o3Qev7TDgSYQJlScRr-iA25RYQa0MYxWodKACE4W5HaQGn-Y4kCtutPANmm7fGBNZjCGUkbENcN5z7HxCpOUubXC89gKi69aHXiBKwrQr2Ani_pe6Oi2mKJ8-XUpQL0J0bHJ2-qdr_AvedX5vePl_3rEr7FKLtuFNox5X2ZYprrGdj20-wXX2c0gJ-6tp5eC7WaJLBw5Ph8dH_BkU88IrCVVX8yVQ4VVdQl5ocLn-4Mph4C3kSwN5K-NGA51rA9Xsu1-o3_UMppMFTUwlJNSpAyYFvrGaLaq548uFspZ0Gla-cNPnBQ4gLF_iBJT5DxhXgGpIjAGNd4Pzq0n5EnJA_acy1PUSUM3AUQbfYMdnsrM32TZujLnNYKAlT3lihI0xWtShSK0ObRJqJVKhZdpjT1DcskXDZ5K5ODCIs0YuM5LLrJHLHvM7icxUyxlPrUumG995vn7nX_5htxPerLWeZfZbcnvs4fox2j26zMoLM69xTBxzR67EN4wRGLATAaXosVuNEq2XhNAfkXUq7mxewAO2g0qTHe6PDu6yi7jwqEnb2mXb1bI299gF9Q0_-PK-035gn89aeX4BY7afTg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fucosyltransferase+2+%28FUT2%29+non-secretor+status+and+blood+group+B+are+associated+with+elevated+serum+lipase+activity+in+asymptomatic+subjects%2C+and+an+increased+risk+for+chronic+pancreatitis%3A+a+genetic+association+study&rft.jtitle=Gut&rft.au=Weiss%2C+Frank+Ulrich&rft.au=Schurmann%2C+Claudia&rft.au=Guenther%2C+Annett&rft.au=Ernst%2C+Florian&rft.date=2015-04-01&rft.pub=BMJ+Publishing+Group+LTD&rft.issn=0017-5749&rft.eissn=1468-3288&rft.volume=64&rft.issue=4&rft.spage=646&rft_id=info:doi/10.1136%2Fgutjnl-2014-306930&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=4014717821
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0017-5749&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0017-5749&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0017-5749&client=summon