Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis

ObjectiveThe medicinal fungus Ophiocordyceps sinensis and its anamorph Hirsutella sinensis have a long history of use in traditional Chinese medicine for their immunomodulatory properties. Alterations of the gut microbiota have been described in obesity and type 2 diabetes. We examined the possibili...

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Bibliographic Details
Published in:	Gut Vol. 68; no. 2; pp. 248 - 262
Main Authors:	Wu, Tsung-Ru, Lin, Chuan-Sheng, Chang, Chih-Jung, Lin, Tzu-Lung, Martel, Jan, Ko, Yun-Fei, Ojcius, David M, Lu, Chia-Chen, Young, John D, Lai, Hsin-Chih
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group LTD 01.02.2019
Subjects:	Adipose tissue Animals Bacteria Body weight gain Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diet Digestive system Fungi Gastrointestinal tract Genomics High fat diet Hirsutella sinensis Immunomodulation Imperfect state Inflammation Insulin Insulin resistance Intestinal microflora Intestine Lipid metabolism Liver diseases Metabolic disorders Metabolites Microbiota Molecular weight Neomycin Obesity Parabacteroides Polysaccharides Prebiotics Probiotics rRNA 16S Thermogenesis Traditional Chinese medicine Transplantation Tumor necrosis factor-TNF Weight control United States > US Taiwan nutrition diabetes mellitus prebiotic colonic microflora obesity
ISSN:	0017-5749, 1468-3288, 1468-3288
Online Access:	Get full text
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