Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

Mendelian randomisation (MR) studies allow a better understanding of the causal effects of modifiable exposures on health outcomes, but the published evidence is often hampered by inadequate reporting. Reporting guidelines help authors effectively communicate all critical information about what was...

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Veröffentlicht in:BMJ (Online) Jg. 375; S. n2233
Hauptverfasser: Skrivankova, Veronika W, Richmond, Rebecca C, Woolf, Benjamin A R, Davies, Neil M, Swanson, Sonja A, VanderWeele, Tyler J, Timpson, Nicholas J, Higgins, Julian P T, Dimou, Niki, Langenberg, Claudia, Loder, Elizabeth W, Golub, Robert M, Egger, Matthias, Davey Smith, George, Richards, J Brent
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England British Medical Journal Publishing Group 26.10.2021
BMJ Publishing Group LTD
BMJ Publishing Group Ltd
Schlagworte:
Alcohol
Bias
Bone marrow
Causality
Disease
Epidemiologic Research Design
Epidemiology
Estimates
Genomes
Guidelines as Topic
Humans
Mendelian Randomization Analysis - methods
Mendelian Randomization Analysis - standards
Observational studies
Observational Studies as Topic - standards
Polymorphism
Proteins
Research Methods & Reporting
Stem cell transplantation
Twins
Variables
ISSN:1756-1833, 0959-8138, 1756-1833
Online-Zugang:Volltext
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Zusammenfassung:Mendelian randomisation (MR) studies allow a better understanding of the causal effects of modifiable exposures on health outcomes, but the published evidence is often hampered by inadequate reporting. Reporting guidelines help authors effectively communicate all critical information about what was done and what was found. STROBE-MR (strengthening the reporting of observational studies in epidemiology using mendelian randomisation) assists authors in reporting their MR research clearly and transparently. Adopting STROBE-MR should help readers, reviewers, and journal editors evaluate the quality of published MR studies. This article explains the 20 items of the STROBE-MR checklist, along with their meaning and rationale, using terms defined in a glossary. Examples of transparent reporting are used for each item to illustrate best practices.
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ISSN:1756-1833
0959-8138
1756-1833
DOI:10.1136/bmj.n2233