Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

Mendelian randomisation (MR) studies allow a better understanding of the causal effects of modifiable exposures on health outcomes, but the published evidence is often hampered by inadequate reporting. Reporting guidelines help authors effectively communicate all critical information about what was...

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Vydáno v:BMJ (Online) Ročník 375; s. n2233
Hlavní autoři: Skrivankova, Veronika W, Richmond, Rebecca C, Woolf, Benjamin A R, Davies, Neil M, Swanson, Sonja A, VanderWeele, Tyler J, Timpson, Nicholas J, Higgins, Julian P T, Dimou, Niki, Langenberg, Claudia, Loder, Elizabeth W, Golub, Robert M, Egger, Matthias, Davey Smith, George, Richards, J Brent
Médium: Journal Article
Jazyk:angličtina
Vydáno: England British Medical Journal Publishing Group 26.10.2021
BMJ Publishing Group LTD
BMJ Publishing Group Ltd
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ISSN:1756-1833, 0959-8138, 1756-1833
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Abstract Mendelian randomisation (MR) studies allow a better understanding of the causal effects of modifiable exposures on health outcomes, but the published evidence is often hampered by inadequate reporting. Reporting guidelines help authors effectively communicate all critical information about what was done and what was found. STROBE-MR (strengthening the reporting of observational studies in epidemiology using mendelian randomisation) assists authors in reporting their MR research clearly and transparently. Adopting STROBE-MR should help readers, reviewers, and journal editors evaluate the quality of published MR studies. This article explains the 20 items of the STROBE-MR checklist, along with their meaning and rationale, using terms defined in a glossary. Examples of transparent reporting are used for each item to illustrate best practices.
AbstractList Mendelian randomisation (MR) studies allow a better understanding of the causal effects of modifiable exposures on health outcomes, but the published evidence is often hampered by inadequate reporting. Reporting guidelines help authors effectively communicate all critical information about what was done and what was found. STROBE-MR (strengthening the reporting of observational studies in epidemiology using mendelian randomisation) assists authors in reporting their MR research clearly and transparently. Adopting STROBE-MR should help readers, reviewers, and journal editors evaluate the quality of published MR studies. This article explains the 20 items of the STROBE-MR checklist, along with their meaning and rationale, using terms defined in a glossary. Examples of transparent reporting are used for each item to illustrate best practices.
Author Dimou, Niki
Egger, Matthias
Richmond, Rebecca C
Timpson, Nicholas J
Loder, Elizabeth W
Swanson, Sonja A
VanderWeele, Tyler J
Langenberg, Claudia
Davies, Neil M
Davey Smith, George
Skrivankova, Veronika W
Higgins, Julian P T
Richards, J Brent
Woolf, Benjamin A R
Golub, Robert M
Author_xml – sequence: 1
  givenname: Veronika W
  surname: Skrivankova
  fullname: Skrivankova, Veronika W
  organization: Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
– sequence: 2
  givenname: Rebecca C
  surname: Richmond
  fullname: Richmond, Rebecca C
  organization: Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
– sequence: 3
  givenname: Benjamin A R
  surname: Woolf
  fullname: Woolf, Benjamin A R
  organization: Department of Psychological Science, University of Bristol, Bristol, UK
– sequence: 4
  givenname: Neil M
  surname: Davies
  fullname: Davies, Neil M
  organization: K G Jebsen Centre for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
– sequence: 5
  givenname: Sonja A
  surname: Swanson
  fullname: Swanson, Sonja A
  organization: Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands
– sequence: 6
  givenname: Tyler J
  surname: VanderWeele
  fullname: VanderWeele, Tyler J
  organization: Department of Epidemiology, Harvard T H Chan School of Public Health, Boston, MA, USA
– sequence: 7
  givenname: Nicholas J
  surname: Timpson
  fullname: Timpson, Nicholas J
  organization: Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
– sequence: 8
  givenname: Julian P T
  surname: Higgins
  fullname: Higgins, Julian P T
  organization: NIHR Bristol Biomedical Research Centre, Bristol, UK
– sequence: 9
  givenname: Niki
  surname: Dimou
  fullname: Dimou, Niki
  organization: Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
– sequence: 10
  givenname: Claudia
  surname: Langenberg
  fullname: Langenberg, Claudia
  organization: MRC Epidemiology Unit, University of Cambridge, Cambridge, UK
– sequence: 11
  givenname: Elizabeth W
  surname: Loder
  fullname: Loder, Elizabeth W
  organization: The BMJ, London, UK
– sequence: 12
  givenname: Robert M
  surname: Golub
  fullname: Golub, Robert M
  organization: Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
– sequence: 13
  givenname: Matthias
  surname: Egger
  fullname: Egger, Matthias
  organization: Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa
– sequence: 14
  givenname: George
  surname: Davey Smith
  fullname: Davey Smith, George
  organization: NIHR Bristol Biomedical Research Centre, Bristol, UK
– sequence: 15
  givenname: J Brent
  orcidid: 0000-0002-3746-9086
  surname: Richards
  fullname: Richards, J Brent
  email: contact@strobe
  organization: Department of Twin Research and Genetic Epidemiology, King’s College London, University of London, London, UK
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34702754$$D View this record in MEDLINE/PubMed
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PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle BMJ (Online)
PublicationTitleAbbrev BMJ
PublicationTitleAlternate BMJ
PublicationYear 2021
Publisher British Medical Journal Publishing Group
BMJ Publishing Group LTD
BMJ Publishing Group Ltd
Publisher_xml – name: British Medical Journal Publishing Group
– name: BMJ Publishing Group LTD
– name: BMJ Publishing Group Ltd
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Snippet Mendelian randomisation (MR) studies allow a better understanding of the causal effects of modifiable exposures on health outcomes, but the published evidence...
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StartPage n2233
SubjectTerms Alcohol
Bias
Bone marrow
Causality
Disease
Epidemiologic Research Design
Epidemiology
Estimates
Genomes
Guidelines as Topic
Humans
Mendelian Randomization Analysis - methods
Mendelian Randomization Analysis - standards
Observational studies
Observational Studies as Topic - standards
Polymorphism
Proteins
Research Methods & Reporting
Stem cell transplantation
Twins
Variables
Title Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration
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https://pubmed.ncbi.nlm.nih.gov/PMC8546498
Volume 375
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