14-year case series of eyelid sebaceous gland carcinoma in Chinese patients and review of management

AimsSebaceous gland carcinoma (SGC) of the eyelid is a rare but potentially deadly cancer. The purpose of this study was to determine whether the American Joint Committee on Cancer (AJCC) 7th Edition T category for SGC correlated with metastasis and survival in the Chinese population.MethodsThis was...

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Vydáno v:	British journal of ophthalmology Ročník 102; číslo 12; s. 1723 - 1727
Hlavní autoři:	Lam, Stacey C, Li, Emmy Y M, Yuen, Hunter K L
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.12.2018 BMJ Publishing Group LTD
Témata:	Adenocarcinoma, Sebaceous - diagnostic imaging Adenocarcinoma, Sebaceous - mortality Adenocarcinoma, Sebaceous - pathology Adult Aged Aged, 80 and over AJCC Asian Continental Ancestry Group Cancer therapies Clinical science Cohort Studies Committees Disease-Free Survival Eye cancer Eyelid Neoplasms - diagnosis Eyelid Neoplasms - mortality Eyelid Neoplasms - pathology Female Females Head & neck cancer Histopathology Hong Kong Humans lymph node metastasis Lymphatic Metastasis Male malignant eyelid tumour Medical imaging Medical prognosis Metastasis Middle Aged Neoplasm Recurrence, Local - pathology Neoplasm Staging Ophthalmology Patients Population Prognosis Radiation therapy Retrospective Studies sebaceous carcinoma Sebaceous Gland Neoplasms - diagnosis Sebaceous Gland Neoplasms - mortality Sebaceous Gland Neoplasms - pathology Sentinel Lymph Node Biopsy Surgery Surgical outcomes Survival Rate Tumors Hong Kong Hong Kong China China malignant eyelid tumour Hong Kong sebaceous carcinoma AJCC lymph node metastasis
ISSN:	0007-1161, 1468-2079, 1468-2079
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Shrnutí:	AimsSebaceous gland carcinoma (SGC) of the eyelid is a rare but potentially deadly cancer. The purpose of this study was to determine whether the American Joint Committee on Cancer (AJCC) 7th Edition T category for SGC correlated with metastasis and survival in the Chinese population.MethodsThis was a retrospective, single-centre cohort study. Patients with surgically resected eyelid SGC between January 2001 and May 2015 at the Hong Kong Eye Hospital were reviewed. Tumours were staged using the AJCC criteria. The main outcome measures included local recurrence, metastasis and death. Disease-free survival (DFS) was measured from the completion of treatment; overall survival was measured from the date of initial diagnosis.ResultsThe study included 22 Chinese patients with a mean age of 65.4 years. The majority presented as a nodular lesion (91%) with 12 eyes (54.5%) initially misdiagnosed and a mean presentation time of 1 year. It was found that those with AJCC stage T2b or higher were significantly associated with lymph node metastasis (P=0.002) when compared with those with stage T2a. Older age at diagnosis (P=0.035) and no misdiagnosis (P=0.025) were associated with shorter DFS. Those with stage 3a or higher were associated with shorter DFS (P=0.007) and overall survival (P=0.024).ConclusionSimilar to previous reports, in this Chinese cohort, AJCC staging for SGC correlated with lymph node metastasis, DFS and overall survival. Those with stage 2b or higher on presentation will need closer surveillance for lymph node metastasis and may benefit from sentinel lymph node biopsy.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0007-1161 1468-2079 1468-2079
DOI:	10.1136/bjophthalmol-2017-311533