Long-term effect of low frequency stimulation of STN on dysphagia, freezing of gait and other motor symptoms in PD

ObjectiveTo evaluate the long-term effect of 60 Hz stimulation of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other motor symptoms in patients with Parkinson’s disease (PD) who have FOG at the usual 130 Hz stimulation.MethodsThis is a prospective, sequence randomised, cros...

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Vydáno v:Journal of neurology, neurosurgery and psychiatry Ročník 89; číslo 9; s. 989 - 994
Hlavní autoři: Xie, Tao, Bloom, Lisa, Padmanaban, Mahesh, Bertacchi, Breanna, Kang, Wenjun, MacCracken, Ellen, Dachman, Abraham, Vigil, Julie, Satzer, David, Zadikoff, Cindy, Markopoulou, Katerina, Warnke, Peter, Kang, Un Jung
Médium: Journal Article
Jazyk:angličtina
Vydáno: England BMJ Publishing Group LTD 01.09.2018
Témata:
Aged
Cross-Over Studies
Deep Brain Stimulation
Deglutition Disorders - etiology
Deglutition Disorders - therapy
Double-Blind Method
Dysphagia
Female
Gait
Gait Disorders, Neurologic - etiology
Gait Disorders, Neurologic - therapy
Humans
Male
Middle Aged
Neurology
Parkinson Disease - complications
Parkinson Disease - therapy
Parkinson's disease
Patients
Prospective Studies
Subthalamic Nucleus
Time Factors
Treatment Outcome
DBS
freezing
gait
dysphagia
STN
Parkinson’s disease
frequency
ISSN:0022-3050, 1468-330X, 1468-330X
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Abstract ObjectiveTo evaluate the long-term effect of 60 Hz stimulation of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other motor symptoms in patients with Parkinson’s disease (PD) who have FOG at the usual 130 Hz stimulation.MethodsThis is a prospective, sequence randomised, crossover, double-blind study. PD patients with medication refractory FOG at 130 Hz stimulation of the STN were randomised to the sequences of 130 Hz, 60 Hz or deep brain stimulation off to assess swallowing function (videofluoroscopic evaluation and swallowing questionnaire), FOG severity (stand–walk–sit test and FOG questionnaire) and motor function (Unified PD Rating Scale, Part III motor examination (UPDRS-III)) at initial visit (V1) and follow-up visit (V2, after being on 60 Hz stimulation for an average of 14.5 months), in their usual medications on state. The frequency of aspiration events, perceived swallowing difficulty and FOG severity at 60 Hz compared with 130 Hz stimulation at V2, and their corresponding changes at V2 compared with V1 at 60 Hz were set as primary outcomes, with similar comparisons in UPDRS-III and its subscores as secondary outcomes.ResultsAll 11 enrolled participants completed V1 and 10 completed V2. We found the benefits of 60 Hz stimulation compared with 130 Hz in reducing aspiration frequency, perceived swallowing difficulty, FOG severity, bradykinesia and overall axial and motor symptoms at V1 and persistent benefits on all of them except dysphagia at V2, with overall decreasing efficacy when comparing V2 to V1.ConclusionsThe 60 Hz stimulation, when compared with 130 Hz, has long-term benefits on reducing FOG, bradykinesia and overall axial and motor symptoms except dysphagia, although the overall benefits decrease with long-term use.Clinical trial registration NCT02549859; Pre-results.
AbstractList To evaluate the long-term effect of 60 Hz stimulation of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other motor symptoms in patients with Parkinson's disease (PD) who have FOG at the usual 130 Hz stimulation. This is a prospective, sequence randomised, crossover, double-blind study. PD patients with medication refractory FOG at 130 Hz stimulation of the STN were randomised to the sequences of 130 Hz, 60 Hz or deep brain stimulation off to assess swallowing function (videofluoroscopic evaluation and swallowing questionnaire), FOG severity (stand-walk-sit test and FOG questionnaire) and motor function (Unified PD Rating Scale, Part III motor examination (UPDRS-III)) at initial visit (V1) and follow-up visit (V2, after being on 60 Hz stimulation for an average of 14.5 months), in their usual medications on state. The frequency of aspiration events, perceived swallowing difficulty and FOG severity at 60 Hz compared with 130 Hz stimulation at V2, and their corresponding changes at V2 compared with V1 at 60 Hz were set as primary outcomes, with similar comparisons in UPDRS-III and its subscores as secondary outcomes. All 11 enrolled participants completed V1 and 10 completed V2. We found the benefits of 60 Hz stimulation compared with 130 Hz in reducing aspiration frequency, perceived swallowing difficulty, FOG severity, bradykinesia and overall axial and motor symptoms at V1 and persistent benefits on all of them except dysphagia at V2, with overall decreasing efficacy when comparing V2 to V1. The 60 Hz stimulation, when compared with 130 Hz, has long-term benefits on reducing FOG, bradykinesia and overall axial and motor symptoms except dysphagia, although the overall benefits decrease with long-term use. NCT02549859; Pre-results.
ObjectiveTo evaluate the long-term effect of 60 Hz stimulation of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other motor symptoms in patients with Parkinson’s disease (PD) who have FOG at the usual 130 Hz stimulation.MethodsThis is a prospective, sequence randomised, crossover, double-blind study. PD patients with medication refractory FOG at 130 Hz stimulation of the STN were randomised to the sequences of 130 Hz, 60 Hz or deep brain stimulation off to assess swallowing function (videofluoroscopic evaluation and swallowing questionnaire), FOG severity (stand–walk–sit test and FOG questionnaire) and motor function (Unified PD Rating Scale, Part III motor examination (UPDRS-III)) at initial visit (V1) and follow-up visit (V2, after being on 60 Hz stimulation for an average of 14.5 months), in their usual medications on state. The frequency of aspiration events, perceived swallowing difficulty and FOG severity at 60 Hz compared with 130 Hz stimulation at V2, and their corresponding changes at V2 compared with V1 at 60 Hz were set as primary outcomes, with similar comparisons in UPDRS-III and its subscores as secondary outcomes.ResultsAll 11 enrolled participants completed V1 and 10 completed V2. We found the benefits of 60 Hz stimulation compared with 130 Hz in reducing aspiration frequency, perceived swallowing difficulty, FOG severity, bradykinesia and overall axial and motor symptoms at V1 and persistent benefits on all of them except dysphagia at V2, with overall decreasing efficacy when comparing V2 to V1.ConclusionsThe 60 Hz stimulation, when compared with 130 Hz, has long-term benefits on reducing FOG, bradykinesia and overall axial and motor symptoms except dysphagia, although the overall benefits decrease with long-term use.Clinical trial registration NCT02549859; Pre-results.
To evaluate the long-term effect of 60 Hz stimulation of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other motor symptoms in patients with Parkinson's disease (PD) who have FOG at the usual 130 Hz stimulation.OBJECTIVETo evaluate the long-term effect of 60 Hz stimulation of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other motor symptoms in patients with Parkinson's disease (PD) who have FOG at the usual 130 Hz stimulation.This is a prospective, sequence randomised, crossover, double-blind study. PD patients with medication refractory FOG at 130 Hz stimulation of the STN were randomised to the sequences of 130 Hz, 60 Hz or deep brain stimulation off to assess swallowing function (videofluoroscopic evaluation and swallowing questionnaire), FOG severity (stand-walk-sit test and FOG questionnaire) and motor function (Unified PD Rating Scale, Part III motor examination (UPDRS-III)) at initial visit (V1) and follow-up visit (V2, after being on 60 Hz stimulation for an average of 14.5 months), in their usual medications on state. The frequency of aspiration events, perceived swallowing difficulty and FOG severity at 60 Hz compared with 130 Hz stimulation at V2, and their corresponding changes at V2 compared with V1 at 60 Hz were set as primary outcomes, with similar comparisons in UPDRS-III and its subscores as secondary outcomes.METHODSThis is a prospective, sequence randomised, crossover, double-blind study. PD patients with medication refractory FOG at 130 Hz stimulation of the STN were randomised to the sequences of 130 Hz, 60 Hz or deep brain stimulation off to assess swallowing function (videofluoroscopic evaluation and swallowing questionnaire), FOG severity (stand-walk-sit test and FOG questionnaire) and motor function (Unified PD Rating Scale, Part III motor examination (UPDRS-III)) at initial visit (V1) and follow-up visit (V2, after being on 60 Hz stimulation for an average of 14.5 months), in their usual medications on state. The frequency of aspiration events, perceived swallowing difficulty and FOG severity at 60 Hz compared with 130 Hz stimulation at V2, and their corresponding changes at V2 compared with V1 at 60 Hz were set as primary outcomes, with similar comparisons in UPDRS-III and its subscores as secondary outcomes.All 11 enrolled participants completed V1 and 10 completed V2. We found the benefits of 60 Hz stimulation compared with 130 Hz in reducing aspiration frequency, perceived swallowing difficulty, FOG severity, bradykinesia and overall axial and motor symptoms at V1 and persistent benefits on all of them except dysphagia at V2, with overall decreasing efficacy when comparing V2 to V1.RESULTSAll 11 enrolled participants completed V1 and 10 completed V2. We found the benefits of 60 Hz stimulation compared with 130 Hz in reducing aspiration frequency, perceived swallowing difficulty, FOG severity, bradykinesia and overall axial and motor symptoms at V1 and persistent benefits on all of them except dysphagia at V2, with overall decreasing efficacy when comparing V2 to V1.The 60 Hz stimulation, when compared with 130 Hz, has long-term benefits on reducing FOG, bradykinesia and overall axial and motor symptoms except dysphagia, although the overall benefits decrease with long-term use.CONCLUSIONSThe 60 Hz stimulation, when compared with 130 Hz, has long-term benefits on reducing FOG, bradykinesia and overall axial and motor symptoms except dysphagia, although the overall benefits decrease with long-term use.NCT02549859; Pre-results.CLINICAL TRIAL REGISTRATIONNCT02549859; Pre-results.
ObjectiveTo evaluate the long-term effect of 60 Hz stimulation of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other motor symptoms in patients with Parkinson’s disease (PD) who have FOG at the usual 130 Hz stimulation.MethodsThis is a prospective, sequence randomised, crossover, double-blind study. PD patients with medication refractory FOG at 130 Hz stimulation of the STN were randomised to the sequences of 130 Hz, 60 Hz or deep brain stimulation off to assess swallowing function (videofluoroscopic evaluation and swallowing questionnaire), FOG severity (stand–walk–sit test and FOG questionnaire) and motor function (Unified PD Rating Scale, Part III motor examination (UPDRS-III)) at initial visit (V1) and follow-up visit (V2, after being on 60 Hz stimulation for an average of 14.5 months), in their usual medications on state. The frequency of aspiration events, perceived swallowing difficulty and FOG severity at 60 Hz compared with 130 Hz stimulation at V2, and their corresponding changes at V2 compared with V1 at 60 Hz were set as primary outcomes, with similar comparisons in UPDRS-III and its subscores as secondary outcomes.ResultsAll 11 enrolled participants completed V1 and 10 completed V2. We found the benefits of 60 Hz stimulation compared with 130 Hz in reducing aspiration frequency, perceived swallowing difficulty, FOG severity, bradykinesia and overall axial and motor symptoms at V1 and persistent benefits on all of them except dysphagia at V2, with overall decreasing efficacy when comparing V2 to V1.ConclusionsThe 60 Hz stimulation, when compared with 130 Hz, has long-term benefits on reducing FOG, bradykinesia and overall axial and motor symptoms except dysphagia, although the overall benefits decrease with long-term use.Clinical trial registrationNCT02549859; Pre-results.
Author Bloom, Lisa
Zadikoff, Cindy
Warnke, Peter
Dachman, Abraham
Xie, Tao
Kang, Un Jung
Markopoulou, Katerina
Satzer, David
Kang, Wenjun
MacCracken, Ellen
Vigil, Julie
Padmanaban, Mahesh
Bertacchi, Breanna
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  email: txie@bsd.uchicago.edu
  organization: Department of Neurology, University of Chicago Medicine, Chicago, Illinois, USA
– sequence: 2
  givenname: Lisa
  surname: Bloom
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  email: txie@bsd.uchicago.edu
  organization: Speech and Swallowing Section, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA
– sequence: 3
  givenname: Mahesh
  surname: Padmanaban
  fullname: Padmanaban, Mahesh
  email: txie@bsd.uchicago.edu
  organization: Department of Neurology, University of Chicago Medicine, Chicago, Illinois, USA
– sequence: 4
  givenname: Breanna
  surname: Bertacchi
  fullname: Bertacchi, Breanna
  email: txie@bsd.uchicago.edu
  organization: Department of Neurology, University of Chicago Medicine, Chicago, Illinois, USA
– sequence: 5
  givenname: Wenjun
  surname: Kang
  fullname: Kang, Wenjun
  email: txie@bsd.uchicago.edu
  organization: Center for Research Informatics, University of Chicago, Chicago, Illinois, USA
– sequence: 6
  givenname: Ellen
  surname: MacCracken
  fullname: MacCracken, Ellen
  email: txie@bsd.uchicago.edu
  organization: Speech and Swallowing Section, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA
– sequence: 7
  givenname: Abraham
  surname: Dachman
  fullname: Dachman, Abraham
  email: txie@bsd.uchicago.edu
  organization: Department of Radiology, University of Chicago Medicine, Chicago, Illinois, USA
– sequence: 8
  givenname: Julie
  surname: Vigil
  fullname: Vigil, Julie
  email: txie@bsd.uchicago.edu
  organization: Speech and Swallowing Section, Department of Surgery, University of Chicago Medicine, Chicago, Illinois, USA
– sequence: 9
  givenname: David
  surname: Satzer
  fullname: Satzer, David
  email: txie@bsd.uchicago.edu
  organization: Department of Neurosurgery, University of Chicago Medicine, Chicago, Illinois, USA
– sequence: 10
  givenname: Cindy
  surname: Zadikoff
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  email: txie@bsd.uchicago.edu
  organization: Department of Neurology, Northwestern University Medical Center, Chicago, Illinois, USA
– sequence: 11
  givenname: Katerina
  surname: Markopoulou
  fullname: Markopoulou, Katerina
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  organization: Department of Neurology, NorthShore University HealthSystem, Glenview, Illinois, USA
– sequence: 12
  givenname: Peter
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  email: txie@bsd.uchicago.edu
  organization: Department of Neurosurgery, University of Chicago Medicine, Chicago, Illinois, USA
– sequence: 13
  givenname: Un Jung
  surname: Kang
  fullname: Kang, Un Jung
  email: txie@bsd.uchicago.edu
  organization: Department of Neurology, Columbia University Medical Center, New York City, New York, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29654112$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
2018 Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Copyright_xml – notice: Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
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ISSN 0022-3050
1468-330X
IngestDate Fri Sep 05 11:35:55 EDT 2025
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Sat Nov 29 02:37:19 EST 2025
Thu Apr 24 23:06:40 EDT 2025
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IsScholarly true
Issue 9
Keywords DBS
freezing
gait
dysphagia
STN
Parkinson’s disease
frequency
Language English
License Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
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PublicationTitle Journal of neurology, neurosurgery and psychiatry
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Snippet ObjectiveTo evaluate the long-term effect of 60 Hz stimulation of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other motor symptoms...
To evaluate the long-term effect of 60 Hz stimulation of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other motor symptoms in...
ObjectiveTo evaluate the long-term effect of 60 Hz stimulation of the subthalamic nucleus (STN) on dysphagia, freezing of gait (FOG) and other motor symptoms...
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Enrichment Source
Publisher
StartPage 989
SubjectTerms Aged
Cross-Over Studies
Deep Brain Stimulation
Deglutition Disorders - etiology
Deglutition Disorders - therapy
Double-Blind Method
Dysphagia
Female
Gait
Gait Disorders, Neurologic - etiology
Gait Disorders, Neurologic - therapy
Humans
Male
Middle Aged
Neurology
Parkinson Disease - complications
Parkinson Disease - therapy
Parkinson's disease
Patients
Prospective Studies
Subthalamic Nucleus
Time Factors
Treatment Outcome
Title Long-term effect of low frequency stimulation of STN on dysphagia, freezing of gait and other motor symptoms in PD
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https://www.ncbi.nlm.nih.gov/pubmed/29654112
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Volume 89
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