Cyclin E1 overexpression triggers interferon signaling and is associated with antitumor immunity in breast cancer

BackgroundCyclin E1 overexpression drives oncogenesis in several cancers through deregulation of DNA replication and induction of genomic instability, which may potentially trigger immune signaling via cytoplasmic DNA. However, the effects of cyclin E1 overexpression on tumor immunity and its effect...

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Bibliographic Details
Published in:	Journal for immunotherapy of cancer Vol. 13; no. 3; p. e009239
Main Authors:	Yu, Shibo, Stappenbelt, Chantal, Chen, Mengting, Dekker, Mirte, Bhattacharya, Arkajyoti, van der Sluis, Tineke, Zwager, Mieke C, Schröder, Carolien P, Fehrmann, Rudolf S N, van Vugt, Marcel A T M, van der Vegt, Bert
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd 17.03.2025 BMJ Publishing Group LTD BMJ Publishing Group
Subjects:	Breast Cancer Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell cycle Cell Line, Tumor Cyclin E - genetics Cyclin E - metabolism Cyclin-dependent kinases Cytoplasm DNA damage Female Flow cytometry Gene expression Humans Immunotherapy Immunotherapy biomarkers Interferon Interferons - metabolism Kinases Kruskal-Wallis test Medical prognosis Oncogene Proteins - genetics Oncogene Proteins - metabolism Patients Regression analysis Signal Transduction Survival analysis Taxonomy Tumor Microenvironment - immunology Tumors Breast Cancer Immunotherapy
ISSN:	2051-1426, 2051-1426
Online Access:	Get full text
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