Relation of IGF-I with subclinical cardiovascular markers including intima-media thickness, left ventricular mass index and NT-proBNP

Several studies revealed relations between low or high insulin-like growth factor I (IGF-I) levels and risk of cardiovascular diseases or mortality, whereas the mechanisms behind these associations are still unknown. The study aimed to explore the relations between IGF-I and changes in surrogate mar...

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Bibliographic Details
Published in:Endocrine Connections Vol. 182; no. 1; pp. 79 - 90
Main Authors: Eichner, Maximilian, Wallaschofski, Henri, Schminke, Ulf, Völzke, Henry, Dörr, Marcus, Felix, Stephan B, Nauck, Matthias, Friedrich, Nele
Format: Journal Article
Language:English
Published: England Bioscientifica 01.01.2020
Subjects:
Adult
Aged
Cardiovascular Diseases - blood
Cardiovascular Diseases - pathology
Carotid Arteries - metabolism
Carotid Arteries - physiology
Carotid Intima-Media Thickness
Cohort Studies
Echocardiography
Female
Humans
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-Like Growth Factor Binding Protein 3 - metabolism
Insulin-Like Growth Factor I - metabolism
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Natriuretic Peptide, Brain - metabolism
Peptide Fragments - blood
Peptide Fragments - metabolism
ISSN:1479-683X, 2049-3614, 1479-683X, 2049-3614
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Summary:Several studies revealed relations between low or high insulin-like growth factor I (IGF-I) levels and risk of cardiovascular diseases or mortality, whereas the mechanisms behind these associations are still unknown. The study aimed to explore the relations between IGF-I and changes in surrogate markers of cardiovascular disease including carotid intima-media thickness (IMT), left ventricular mass index (LVMI) and N-terminal pro-brain natriuretic peptide (NT-proBNP). Longitudinal data of the population-based cohort Study of Health in Pomerania (SHIP) were used. IMT was measured by ultrasonography and LVMI was determined based on echocardiography. IGF-I and IGF-binding protein-3 (IGFBP-3) levels were measured by chemiluminescent immunoassays and the IGF-I/IGFBP-3 ratio was calculated. Mixed linear regression models adjusted for known cardiovascular confounders were performed. Statistical analyses demonstrated relations between low baseline IGF-I levels (beta for ΔIMT per s.d. increase -0.044 (s.e. 0.012)) or IGF-I/IGFBP-3 ratio (beta -0.045 (0.012)) and a long-term IMT increase. No associations between IGF-I, IGFBP-3 or IGF-I/IGFBP-3 ratio and changes in LVMI were detected. With respect to NT-proBNP sex-specific associations with IGF-I were found. In women, higher baseline IGF-I levels (beta for ΔNT-proBNP per s.d. increase 5.92 (2.2)) or IGF-I/IGFBP-3 ratio (beta 4.48 (2.2)) were related to an increase in NT-proBNP levels. Among men, U-shaped relations of baseline levels of IGF-I, IGFBP-3 and the IGF-I/IGFBP-3 ratio with an increase in NT-proBNP were found. The study detected significant relations between IGF-I and long-term changes in IMT and NT-proBNP but not LVMI. These findings argue for different effects of the IGF-I axis with respect to various cardiovascular entities.
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ISSN:1479-683X
2049-3614
1479-683X
2049-3614
DOI:10.1530/EJE-19-0470