Relation of IGF-I with subclinical cardiovascular markers including intima-media thickness, left ventricular mass index and NT-proBNP
Several studies revealed relations between low or high insulin-like growth factor I (IGF-I) levels and risk of cardiovascular diseases or mortality, whereas the mechanisms behind these associations are still unknown. The study aimed to explore the relations between IGF-I and changes in surrogate mar...
Uloženo v:
| Vydáno v: | Endocrine Connections Ročník 182; číslo 1; s. 79 - 90 |
|---|---|
| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
Bioscientifica
01.01.2020
|
| Témata: | |
| ISSN: | 1479-683X, 2049-3614, 1479-683X, 2049-3614 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Several studies revealed relations between low or high insulin-like growth factor I (IGF-I) levels and risk of cardiovascular diseases or mortality, whereas the mechanisms behind these associations are still unknown.
The study aimed to explore the relations between IGF-I and changes in surrogate markers of cardiovascular disease including carotid intima-media thickness (IMT), left ventricular mass index (LVMI) and N-terminal pro-brain natriuretic peptide (NT-proBNP).
Longitudinal data of the population-based cohort Study of Health in Pomerania (SHIP) were used. IMT was measured by ultrasonography and LVMI was determined based on echocardiography. IGF-I and IGF-binding protein-3 (IGFBP-3) levels were measured by chemiluminescent immunoassays and the IGF-I/IGFBP-3 ratio was calculated. Mixed linear regression models adjusted for known cardiovascular confounders were performed.
Statistical analyses demonstrated relations between low baseline IGF-I levels (beta for ΔIMT per s.d. increase -0.044 (s.e. 0.012)) or IGF-I/IGFBP-3 ratio (beta -0.045 (0.012)) and a long-term IMT increase. No associations between IGF-I, IGFBP-3 or IGF-I/IGFBP-3 ratio and changes in LVMI were detected. With respect to NT-proBNP sex-specific associations with IGF-I were found. In women, higher baseline IGF-I levels (beta for ΔNT-proBNP per s.d. increase 5.92 (2.2)) or IGF-I/IGFBP-3 ratio (beta 4.48 (2.2)) were related to an increase in NT-proBNP levels. Among men, U-shaped relations of baseline levels of IGF-I, IGFBP-3 and the IGF-I/IGFBP-3 ratio with an increase in NT-proBNP were found.
The study detected significant relations between IGF-I and long-term changes in IMT and NT-proBNP but not LVMI. These findings argue for different effects of the IGF-I axis with respect to various cardiovascular entities. |
|---|---|
| AbstractList | Several studies revealed relations between low or high insulin-like growth factor I (IGF-I) levels and risk of cardiovascular diseases or mortality, whereas the mechanisms behind these associations are still unknown.OBJECTIVESeveral studies revealed relations between low or high insulin-like growth factor I (IGF-I) levels and risk of cardiovascular diseases or mortality, whereas the mechanisms behind these associations are still unknown.The study aimed to explore the relations between IGF-I and changes in surrogate markers of cardiovascular disease including carotid intima-media thickness (IMT), left ventricular mass index (LVMI) and N-terminal pro-brain natriuretic peptide (NT-proBNP).DESIGNThe study aimed to explore the relations between IGF-I and changes in surrogate markers of cardiovascular disease including carotid intima-media thickness (IMT), left ventricular mass index (LVMI) and N-terminal pro-brain natriuretic peptide (NT-proBNP).Longitudinal data of the population-based cohort Study of Health in Pomerania (SHIP) were used. IMT was measured by ultrasonography and LVMI was determined based on echocardiography. IGF-I and IGF-binding protein-3 (IGFBP-3) levels were measured by chemiluminescent immunoassays and the IGF-I/IGFBP-3 ratio was calculated. Mixed linear regression models adjusted for known cardiovascular confounders were performed.METHODSLongitudinal data of the population-based cohort Study of Health in Pomerania (SHIP) were used. IMT was measured by ultrasonography and LVMI was determined based on echocardiography. IGF-I and IGF-binding protein-3 (IGFBP-3) levels were measured by chemiluminescent immunoassays and the IGF-I/IGFBP-3 ratio was calculated. Mixed linear regression models adjusted for known cardiovascular confounders were performed.Statistical analyses demonstrated relations between low baseline IGF-I levels (beta for ΔIMT per s.d. increase -0.044 (s.e. 0.012)) or IGF-I/IGFBP-3 ratio (beta -0.045 (0.012)) and a long-term IMT increase. No associations between IGF-I, IGFBP-3 or IGF-I/IGFBP-3 ratio and changes in LVMI were detected. With respect to NT-proBNP sex-specific associations with IGF-I were found. In women, higher baseline IGF-I levels (beta for ΔNT-proBNP per s.d. increase 5.92 (2.2)) or IGF-I/IGFBP-3 ratio (beta 4.48 (2.2)) were related to an increase in NT-proBNP levels. Among men, U-shaped relations of baseline levels of IGF-I, IGFBP-3 and the IGF-I/IGFBP-3 ratio with an increase in NT-proBNP were found.RESULTSStatistical analyses demonstrated relations between low baseline IGF-I levels (beta for ΔIMT per s.d. increase -0.044 (s.e. 0.012)) or IGF-I/IGFBP-3 ratio (beta -0.045 (0.012)) and a long-term IMT increase. No associations between IGF-I, IGFBP-3 or IGF-I/IGFBP-3 ratio and changes in LVMI were detected. With respect to NT-proBNP sex-specific associations with IGF-I were found. In women, higher baseline IGF-I levels (beta for ΔNT-proBNP per s.d. increase 5.92 (2.2)) or IGF-I/IGFBP-3 ratio (beta 4.48 (2.2)) were related to an increase in NT-proBNP levels. Among men, U-shaped relations of baseline levels of IGF-I, IGFBP-3 and the IGF-I/IGFBP-3 ratio with an increase in NT-proBNP were found.The study detected significant relations between IGF-I and long-term changes in IMT and NT-proBNP but not LVMI. These findings argue for different effects of the IGF-I axis with respect to various cardiovascular entities.CONCLUSIONSThe study detected significant relations between IGF-I and long-term changes in IMT and NT-proBNP but not LVMI. These findings argue for different effects of the IGF-I axis with respect to various cardiovascular entities. Objective: Several studies revealed relations between low or high insulin -like growth factor I (IGF-I) levels and risk of cardiovascular diseases or mortality, whereas the mechanisms be hind these associations are still unknown. Design: The study aimed to explore the relations between IGF-I and cha nges in surrogate markers of cardiovascular disease including carotid intima-media thickness (IMT), left ve ntricular mass index (LVMI) and N-terminal pro-brain natriuretic peptide (NT-proBNP). Methods: Longitudinal data of the population-based cohort Study of Heal th in Pomerania (SHIP) were used. IMT was measured by ultrasonography and LVMI was determined based on ec hocardiography. IGF-I and IGF-binding protein-3 (IGFBP-3) levels were measured by chemiluminescent immunoassays and the IGF-I/IGFBP-3 ratio was calculated. Mixed linear regression models adjusted for known cardiovascular conf ounders were performed. Results: Statistical analyses demonstrated relations between low baseli ne IGF-I levels (beta for ΔIMT per s.d. increase −0.044 (s.e. 0.012)) or IGF-I/IGFBP-3 ratio (beta −0.045 (0.012)) and a long-term IMT increase. No associations be tween IGF-I, IGFBP-3 or IGF-I/IGFBP-3 ratio and changes in LVMI were detected. With respect to NT-proBNP sex-specific associations with IGF-I were found. In women, higher baseline I GF-I levels (beta for ΔNT-proBNP per s.d. increase 5.92 (2.2)) or IGF-I/IGFBP-3 ratio (beta 4.48 (2.2)) were related to an increase in NT-proBNP levels. Among men, U-shaped relations of baseline levels of IGF-I, IGFBP-3 and the IGF-I/IG FBP-3 ratio with an increase in NT-proBNP were found. Conclusions: The study detected significant relations between IGF-I and long -term changes in IMT and NT-proBNP but not LVMI. These findings argue for different effects of the IGF-I axis with respect to various cardiovascular entities. Several studies revealed relations between low or high insulin-like growth factor I (IGF-I) levels and risk of cardiovascular diseases or mortality, whereas the mechanisms behind these associations are still unknown. The study aimed to explore the relations between IGF-I and changes in surrogate markers of cardiovascular disease including carotid intima-media thickness (IMT), left ventricular mass index (LVMI) and N-terminal pro-brain natriuretic peptide (NT-proBNP). Longitudinal data of the population-based cohort Study of Health in Pomerania (SHIP) were used. IMT was measured by ultrasonography and LVMI was determined based on echocardiography. IGF-I and IGF-binding protein-3 (IGFBP-3) levels were measured by chemiluminescent immunoassays and the IGF-I/IGFBP-3 ratio was calculated. Mixed linear regression models adjusted for known cardiovascular confounders were performed. Statistical analyses demonstrated relations between low baseline IGF-I levels (beta for ΔIMT per s.d. increase -0.044 (s.e. 0.012)) or IGF-I/IGFBP-3 ratio (beta -0.045 (0.012)) and a long-term IMT increase. No associations between IGF-I, IGFBP-3 or IGF-I/IGFBP-3 ratio and changes in LVMI were detected. With respect to NT-proBNP sex-specific associations with IGF-I were found. In women, higher baseline IGF-I levels (beta for ΔNT-proBNP per s.d. increase 5.92 (2.2)) or IGF-I/IGFBP-3 ratio (beta 4.48 (2.2)) were related to an increase in NT-proBNP levels. Among men, U-shaped relations of baseline levels of IGF-I, IGFBP-3 and the IGF-I/IGFBP-3 ratio with an increase in NT-proBNP were found. The study detected significant relations between IGF-I and long-term changes in IMT and NT-proBNP but not LVMI. These findings argue for different effects of the IGF-I axis with respect to various cardiovascular entities. |
| Author | Friedrich, Nele Felix, Stephan B Völzke, Henry Dörr, Marcus Schminke, Ulf Nauck, Matthias Wallaschofski, Henri Eichner, Maximilian |
| Author_xml | – sequence: 1 givenname: Maximilian surname: Eichner fullname: Eichner, Maximilian organization: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany – sequence: 2 givenname: Henri surname: Wallaschofski fullname: Wallaschofski, Henri organization: Schwerpunktpraxis für Diabetes und Hormonerkrankungen, Erfurt, Germany – sequence: 3 givenname: Ulf surname: Schminke fullname: Schminke, Ulf organization: Department of Neurology, University Medicine Greifswald, Greifswald, Germany – sequence: 4 givenname: Henry surname: Völzke fullname: Völzke, Henry organization: DZHK (German Centre for Cardiovascular Research), Greifswald, Germany – sequence: 5 givenname: Marcus surname: Dörr fullname: Dörr, Marcus organization: Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany – sequence: 6 givenname: Stephan B surname: Felix fullname: Felix, Stephan B organization: Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany – sequence: 7 givenname: Matthias surname: Nauck fullname: Nauck, Matthias organization: DZHK (German Centre for Cardiovascular Research), Greifswald, Germany – sequence: 8 givenname: Nele surname: Friedrich fullname: Friedrich, Nele organization: DZHK (German Centre for Cardiovascular Research), Greifswald, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31705797$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNUctu1TAQtVAr-oAVe-QlCwx-xHG8hOq2vVVVECoSu2jiTFq3vnaxnUI_gP8m9CVWczQ658yZmT2yFVNEQt4I_kFoxT-uTlZMWMYbw1-QXdEYy9pO_dj6D--QvVKuOBdto_hLsqOE4dpYs0v-fMMA1adI00TXR4dsTX_5eknLPLjgo3cQqIM8-nQLxc0BMt1AvsZcqI8uzKOPFwuqfgNsg6MHWi-9u45YynsacKr0FmPN_kla_ulG_E0hjvTsnN3k9Pns6yuyPUEo-Pqx7pPvh6vzg2N2-uVoffDplA2N1JW5QXA7Qicm0Brs0BinrdPdoFBxYbQ002SFQSm51CBca8w0OCmNQjkAoton6wffMcFVf5OX1PmuT-D7-0bKFz3k6l3AHgxqgVzLDroGYNE7KzutJ5BoTGsXr3cPXssKP2cstd_44jAEiJjm0ksllNKtku1CfftInYflSM-Dn96g_gKz1ov8 |
| CitedBy_id | crossref_primary_10_1186_s12902_025_01921_4 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 DOA |
| DOI | 10.1530/EJE-19-0470 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic DOAJ Directory of Open Access Journals |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: Open Access: DOAJ - Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Anatomy & Physiology |
| EISSN | 1479-683X 2049-3614 |
| EndPage | 90 |
| ExternalDocumentID | oai_doaj_org_article_a7e51e0528a84aa2bac92855fa2e7769 31705797 |
| Genre | Journal Article |
| GroupedDBID | --- -~X .55 .GJ 0R~ 18M 2WC 3O- 4.4 53G 5GY 5RE 5VS 5WD AABZA AACZT AAPGJ AAPXW AARHZ AAUAY AAVAP AAWDT ABDFA ABEJV ABGNP ABIME ABJNI ABMNT ABNHQ ABOCM ABPIB ABPQP ABPTD ABQNK ABSQV ABVGC ABWST ABXVV ABXZS ACFRR ACGFO ACNCT ACPRK ACUTJ ADBBV ADGKP ADIPN ADMTO ADNBA ADQBN ADVEK ADVOB AEMQT AENEX AFFNX AFGWE AFHIN AFXAL AFYAG AGORE AGQXC AGUTN AHGBF AHMMS AI. AJBYB AJEEA AJNCP ALMA_UNASSIGNED_HOLDINGS ALXQX ANFBD APJGH ATGXG BAWUL BCRHZ BTFSW C1A CGR CS3 CUY CVF DU5 E3Z EBS ECM EIF EJD EMOBN F9R GX1 H13 HZ~ IL9 INIJC J5H KOP KQ8 L7B NPM NU- O9- OAUYM OBFPC OBOKY OCZFY OJZSN OK1 OPAEJ OVD OWPYF P2P ROX SJN TBS TCN TEORI TMA TR2 VH1 W8F WOQ X7M ZGI ZXP 7X8 AAFZV AAKMT AOIJS BCNDV DIK EE- FRJ GROUPED_DOAJ HYE M48 M~E PGMZT RPM |
| ID | FETCH-LOGICAL-b425t-cb109da81fa55a9b47c59c58b3e3017527ff917e22025a1c677fbc2273e2baee3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 4 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000505970300012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1479-683X 2049-3614 |
| IngestDate | Fri Oct 03 12:52:21 EDT 2025 Sat Sep 27 18:07:31 EDT 2025 Mon Jul 21 06:03:46 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-b425t-cb109da81fa55a9b47c59c58b3e3017527ff917e22025a1c677fbc2273e2baee3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://doaj.org/article/a7e51e0528a84aa2bac92855fa2e7769 |
| PMID | 31705797 |
| PQID | 2313356326 |
| PQPubID | 23479 |
| PageCount | 12 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_a7e51e0528a84aa2bac92855fa2e7769 proquest_miscellaneous_2313356326 pubmed_primary_31705797 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-01-01 |
| PublicationDateYYYYMMDD | 2020-01-01 |
| PublicationDate_xml | – month: 01 year: 2020 text: 2020-01-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Endocrine Connections |
| PublicationTitleAlternate | Eur J Endocrinol |
| PublicationYear | 2020 |
| Publisher | Bioscientifica |
| Publisher_xml | – name: Bioscientifica |
| SSID | ssj0016430 ssj0000816830 |
| Score | 2.3187168 |
| Snippet | Several studies revealed relations between low or high insulin-like growth factor I (IGF-I) levels and risk of cardiovascular diseases or mortality, whereas... Objective: Several studies revealed relations between low or high insulin -like growth factor I (IGF-I) levels and risk of cardiovascular diseases or... |
| SourceID | doaj proquest pubmed |
| SourceType | Open Website Aggregation Database Index Database |
| StartPage | 79 |
| SubjectTerms | Adult Aged Cardiovascular Diseases - blood Cardiovascular Diseases - pathology Carotid Arteries - metabolism Carotid Arteries - physiology Carotid Intima-Media Thickness Cohort Studies Echocardiography Female Humans Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor Binding Protein 3 - metabolism Insulin-Like Growth Factor I - metabolism Male Middle Aged Natriuretic Peptide, Brain - blood Natriuretic Peptide, Brain - metabolism Peptide Fragments - blood Peptide Fragments - metabolism |
| Title | Relation of IGF-I with subclinical cardiovascular markers including intima-media thickness, left ventricular mass index and NT-proBNP |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31705797 https://www.proquest.com/docview/2313356326 https://doaj.org/article/a7e51e0528a84aa2bac92855fa2e7769 |
| Volume | 182 |
| WOSCitedRecordID | wos000505970300012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: Open Access: DOAJ - Directory of Open Access Journals customDbUrl: eissn: 1479-683X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000816830 issn: 1479-683X databaseCode: DOA dateStart: 20120101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1479-683X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000816830 issn: 1479-683X databaseCode: M~E dateStart: 20120101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3Pa9swFBZd6KGXsa1dl24rGoydJhpLliUd25G0HdTk0EJuRpIlCGucEjujvezW_7vvycnoDmOXXYQxCMvv6cf3nr73HiGfHVIRpDOs9plnOWBmZp2XTMUizzRYY1mwqdiEKks9m5nps1JfyAnr0wP3gjuxKsgsjCTXVufWcme94VrKaHlQqkihe4B6nhlTaQ_GchKp0AgHCMwEHEKb4DwpRifj72OGsTs5lihOqfr_ji_TOTN5RV5uACI97Qf2muyE5g3ZP23AOF480C80UTaTL3yfPG6pbHQZ6eX5hF1S9KvSdu22EY_U_0E4pQuk46xaOm_87RrPLXjq5gvLUggJRfb7D9z9vtLbEDuKbMjkIkxdW-xXh3tqm5qW1wx-5qycHpCbyfj62wXb1FVgDlZox7zLRqa2OotWSmtcrrw0XmonAix3JbmKEay4wDkAIpv5QqnoPAegE0D8IYi3ZNAsm_COUGGE587oPIY6Lwpj48jVAAEBWILd54shOUPxVnd96owKk1mnF6DiaqPi6l8qHpJPW-VUMPnxRsM2YbluKwCnQsgCIOiQHPZa-_0pgYmClFFH_2MI78keR0M7-V4-kEG3WoePZNf_7Obt6pi8UDN9nGYgtFe_xtCW06snfffhqg |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Relation+of+IGF-I+with+subclinical+cardiovascular+markers+including+intima-media+thickness%2C+left+ventricular+mass+index+and+NT-proBNP&rft.jtitle=Endocrine+Connections&rft.au=Maximilian+Eichner&rft.au=Henri+Wallaschofski&rft.au=Ulf+Schminke&rft.au=Henry+V%C3%B6lzke&rft.date=2020-01-01&rft.pub=Bioscientifica&rft.issn=2049-3614&rft.eissn=2049-3614&rft.volume=182&rft.issue=1&rft.spage=79&rft.epage=90&rft_id=info:doi/10.1530%2FEJE-19-0470&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_a7e51e0528a84aa2bac92855fa2e7769 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1479-683X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1479-683X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1479-683X&client=summon |