Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly

Background: Aging is characterized with immunosenescence associated with a hyper-inflammatory state, characterized by elevated circulating levels of pro-inflammatory mediators. Physical exercise is a potential strategy for improving the immune system dysfunction and chronic inflammation that accompa...

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Vydáno v:African health sciences Ročník 18; číslo 1; s. 120 - 131
Hlavní autoři: Abd El-Kader, Shehab M, Al-Shreef, Fadwa M
Médium: Journal Article
Jazyk:angličtina
Vydáno: Uganda Makerere University Medical School 01.03.2018
Makerere Medical School
Témata:
Adult
aerobic exercise
Aged
aging
Aging - blood
Aging - physiology
Biomarkers - blood
Cytokines - blood
Exercise - physiology
Female
Humans
Immune function
Immune System - metabolism
Inflammation - blood
Inflammation Mediators - blood
inflammatory cytokines
Interleukin-10 - blood
Male
Middle Aged
resistance exercise
Resistance Training - methods
Saudi Arabia
Treatment Outcome
Tumor Necrosis Factor-alpha - blood
aerobic exercise
Immune function
aging
inflammatory cytokines
resistance exercise
ISSN:1680-6905, 1729-0503, 1680-6905, 1729-0503
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Shrnutí:Background: Aging is characterized with immunosenescence associated with a hyper-inflammatory state, characterized by elevated circulating levels of pro-inflammatory mediators. Physical exercise is a potential strategy for improving the immune system dysfunction and chronic inflammation that accompanies aging. However, there is a need to differentiate between aerobic and resistance exercise training regarding human immune system and systemic inflammation among the elderly Saudi population. Objective: The aim of this study was to compare the impact of 6 months of aerobic versus resisted exercise training on inflammatory cytokines and immune system response among elderly. Material and methods: Sixty previously sedentary elderly subjects participated in this study, their age ranged from 61- 66 years. All Subjects were randomly assigned to supervised aerobic exercise intervention group (group A, n=40) or resistance exercise group (group B, n=40). Number of CD3+,CD4+,CD8+ T cells count and CD4/CD8 ratio were quantified, IL-6, TNF-α and IL10 were measured before and after 6 months, at the end of the study. Results: The mean values of CD3+, CD4+ and CD8+ T cells count and IL-10 were significantly increased, whereas the mean values of CD4/CD8 ratio,IL-6 and TNF-α were significantly decreased in group (A) and group (B). Also; there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment. Conclusion: The current study provides evidence that aerobic exercise is more appropriate in modulating the immune system and inflammatory markers among the elderly population.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1680-6905
1729-0503
1680-6905
1729-0503
DOI:10.4314/ahs.v18i1.16