Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD

TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain receptor 3 (DR3), are members of the TNF and TNFR superfamilies, respectively, with recognised roles in regulating innate and adaptive immune responses; additional existence of a decoy receptor, DcR3, indicates a tightly regulated...

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Vydáno v:Gut Ročník 74; číslo 4; s. 652 - 668
Hlavní autoři: Bamias, Giorgos, Menghini, Paola, Pizarro, Theresa T, Cominelli, Fabio
Médium: Journal Article
Jazyk:angličtina
Vydáno: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.04.2025
BMJ Publishing Group LTD
Témata:
Amino acids
Animals
CROHN'S DISEASE
CYTOKINES
Gene polymorphism
Humans
Immune response
Immunology
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - drug therapy
Inflammatory Bowel Diseases - immunology
Intestine
Kinases
Ligands
Lymphoid cells
Monoclonal antibodies
Pathogenesis
Proteins
Recent advances in basic science
Receptors, Tumor Necrosis Factor, Member 25 - antagonists & inhibitors
Receptors, Tumor Necrosis Factor, Member 25 - immunology
Receptors, Tumor Necrosis Factor, Member 25 - metabolism
Receptors, Tumor Necrosis Factor, Member 25 - physiology
Signal Transduction
Stromal cells
Tumor Necrosis Factor Ligand Superfamily Member 15 - antagonists & inhibitors
Tumor Necrosis Factor Ligand Superfamily Member 15 - immunology
Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism
Tumor Necrosis Factor Ligand Superfamily Member 15 - physiology
Tumor necrosis factor receptors
Tumor necrosis factor-TNF
ULCERATIVE COLITIS
ULCERATIVE COLITIS
CROHN'S DISEASE
CYTOKINES
ISSN:0017-5749, 1468-3288, 1468-3288
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Abstract TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain receptor 3 (DR3), are members of the TNF and TNFR superfamilies, respectively, with recognised roles in regulating innate and adaptive immune responses; additional existence of a decoy receptor, DcR3, indicates a tightly regulated cytokine system. The significance of TL1A:DR3 signalling in the pathogenesis of inflammatory bowel disease (IBD) is supported by several converging lines of evidence.To provide a comprehensive understanding of what is currently known regarding the TL1A/DR3 system in the context of IBD.TL1A and DR3 are expressed by cellular subsets with important roles for the initiation and maintenance of intestinal inflammation, serving as potent universal costimulators of effector immune responses, indicating their participation in the pathogenesis of IBD. Recent evidence also supports a homoeostatic role for TL1A:DR3 via regulation of Tregs and innate lymphoid cells. TL1A and DR3 are also expressed by stromal cells and may contribute to inflammation-induced or inflammation-independent intestinal fibrogenesis. Finally, discovery of genetic polymorphisms with functional consequences may allow for patient stratification, including differential responses to TL1A-targeted therapeutics.TL1A:DR3 signalling plays a central and multifaceted role in the immunological pathways that underlie intestinal inflammation, such as that observed in IBD. Such evidence provides the foundation for developing pharmaceutical approaches targeting this ligand-receptor pair in IBD.
AbstractList TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain receptor 3 (DR3), are members of the TNF and TNFR superfamilies, respectively, with recognised roles in regulating innate and adaptive immune responses; additional existence of a decoy receptor, DcR3, indicates a tightly regulated cytokine system. The significance of TL1A:DR3 signalling in the pathogenesis of inflammatory bowel disease (IBD) is supported by several converging lines of evidence. Herein, we aim to provide a comprehensive understanding of what is currently known regarding the TL1A/DR3 system in the context of IBD. TL1A and DR3 are expressed by cellular subsets with important roles for the initiation and maintenance of intestinal inflammation, serving as potent universal costimulators of effector immune responses, indicating their participation in the pathogenesis of IBD. Recent evidence also supports a homoeostatic role for TL1A:DR3 via regulation of Tregs and innate lymphoid cells. TL1A and DR3 are also expressed by stromal cells and may contribute to inflammation-induced or inflammation-independent intestinal fibrogenesis. Finally, discovery of genetic polymorphisms with functional consequences may allow for patient stratification, including differential responses to TL1A-targeted therapeutics. In conclusion, TL1A:DR3 signalling plays a central and multifaceted role in the immunological pathways that underlie intestinal inflammation, such as that observed in IBD. Such evidence provides the foundation for developing pharmaceutical approaches targeting this ligand-receptor pair in IBD.
TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain receptor 3 (DR3), are members of the TNF and TNFR superfamilies, respectively, with recognised roles in regulating innate and adaptive immune responses; additional existence of a decoy receptor, DcR3, indicates a tightly regulated cytokine system. The significance of TL1A:DR3 signalling in the pathogenesis of inflammatory bowel disease (IBD) is supported by several converging lines of evidence.To provide a comprehensive understanding of what is currently known regarding the TL1A/DR3 system in the context of IBD.TL1A and DR3 are expressed by cellular subsets with important roles for the initiation and maintenance of intestinal inflammation, serving as potent universal costimulators of effector immune responses, indicating their participation in the pathogenesis of IBD. Recent evidence also supports a homoeostatic role for TL1A:DR3 via regulation of Tregs and innate lymphoid cells. TL1A and DR3 are also expressed by stromal cells and may contribute to inflammation-induced or inflammation-independent intestinal fibrogenesis. Finally, discovery of genetic polymorphisms with functional consequences may allow for patient stratification, including differential responses to TL1A-targeted therapeutics.TL1A:DR3 signalling plays a central and multifaceted role in the immunological pathways that underlie intestinal inflammation, such as that observed in IBD. Such evidence provides the foundation for developing pharmaceutical approaches targeting this ligand-receptor pair in IBD.
TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain receptor 3 (DR3), are members of the TNF and TNFR superfamilies, respectively, with recognised roles in regulating innate and adaptive immune responses; additional existence of a decoy receptor, DcR3, indicates a tightly regulated cytokine system. The significance of TL1A:DR3 signalling in the pathogenesis of inflammatory bowel disease (IBD) is supported by several converging lines of evidence. Herein, we aim to provide a comprehensive understanding of what is currently known regarding the TL1A/DR3 system in the context of IBD. TL1A and DR3 are expressed by cellular subsets with important roles for the initiation and maintenance of intestinal inflammation, serving as potent universal costimulators of effector immune responses, indicating their participation in the pathogenesis of IBD. Recent evidence also supports a homoeostatic role for TL1A:DR3 via regulation of Tregs and innate lymphoid cells. TL1A and DR3 are also expressed by stromal cells and may contribute to inflammation-induced or inflammation-independent intestinal fibrogenesis. Finally, discovery of genetic polymorphisms with functional consequences may allow for patient stratification, including differential responses to TL1A-targeted therapeutics. In conclusion, TL1A:DR3 signalling plays a central and multifaceted role in the immunological pathways that underlie intestinal inflammation, such as that observed in IBD. Such evidence provides the foundation for developing pharmaceutical approaches targeting this ligand-receptor pair in IBD.TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain receptor 3 (DR3), are members of the TNF and TNFR superfamilies, respectively, with recognised roles in regulating innate and adaptive immune responses; additional existence of a decoy receptor, DcR3, indicates a tightly regulated cytokine system. The significance of TL1A:DR3 signalling in the pathogenesis of inflammatory bowel disease (IBD) is supported by several converging lines of evidence. Herein, we aim to provide a comprehensive understanding of what is currently known regarding the TL1A/DR3 system in the context of IBD. TL1A and DR3 are expressed by cellular subsets with important roles for the initiation and maintenance of intestinal inflammation, serving as potent universal costimulators of effector immune responses, indicating their participation in the pathogenesis of IBD. Recent evidence also supports a homoeostatic role for TL1A:DR3 via regulation of Tregs and innate lymphoid cells. TL1A and DR3 are also expressed by stromal cells and may contribute to inflammation-induced or inflammation-independent intestinal fibrogenesis. Finally, discovery of genetic polymorphisms with functional consequences may allow for patient stratification, including differential responses to TL1A-targeted therapeutics. In conclusion, TL1A:DR3 signalling plays a central and multifaceted role in the immunological pathways that underlie intestinal inflammation, such as that observed in IBD. Such evidence provides the foundation for developing pharmaceutical approaches targeting this ligand-receptor pair in IBD.
Author Pizarro, Theresa T
Cominelli, Fabio
Menghini, Paola
Bamias, Giorgos
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  surname: Bamias
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  organization: GI Unit, 3rd Academic Department of Internal Medicine, National and Kapodistrian University of Athens, Sotiria Hospital, Athens, Greece
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  surname: Menghini
  fullname: Menghini, Paola
  organization: Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
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  givenname: Theresa T
  orcidid: 0000-0003-3163-915X
  surname: Pizarro
  fullname: Pizarro, Theresa T
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  givenname: Fabio
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  surname: Cominelli
  fullname: Cominelli, Fabio
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  organization: Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39266053$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1002/ibd.21638
10.1016/j.cgh.2021.06.011
10.1084/jem.20071364
10.1172/JCI19836
10.1136/gut.2011.241877
10.1093/ecco-jcc/jjac190.0127
10.1073/pnas.1404178111
10.1096/fj.10-166843
10.1073/pnas.0510903103
10.1053/j.gastro.2008.04.037
10.1093/ibd/izab193
10.1038/mi.2012.124
10.1111/ped.12686
10.1097/MIB.0b013e31828075e7
10.1016/j.clim.2013.03.002
10.1111/imr.13322
10.3109/08916934.2014.930735
10.1016/j.immuni.2018.10.014
10.1016/j.humimm.2013.11.006
10.1371/journal.pgen.1007458
10.1101/2024.02.09.579684
10.1093/ibd/izae098
10.1016/j.celrep.2023.112431
10.1038/s41588-023-01384-0
10.1177/0300060520926011
10.1177/1756284820959252
10.1016/j.jcmgh.2023.03.008
10.1371/journal.pone.0004719
10.1093/hmg/ddp005
10.1126/science.274.5289.990
10.1016/j.cellimm.2017.09.005
10.4049/jimmunol.174.8.4985
10.1136/gutjnl-2013-305947
10.1016/j.trsl.2016.08.007
10.14309/ctg.0000000000000706
10.1038/mi.2013.92
10.1097/MIB.0000000000000584
10.1016/j.clim.2008.07.014
10.1016/s0378-1119(97)00509-x
10.1016/j.clim.2010.07.001
10.1074/jbc.M305833200
10.1002/jgh3.12398
10.1073/pnas.94.9.4615
10.1016/j.bone.2003.07.006
10.1186/1471-2369-15-178
10.1556/EuJMI.3.2013.1.2
10.1007/s00439-017-1764-0
10.1016/j.crohns.2014.09.008
10.1007/DCR.0b013e31821b94b3
10.1002/ibd.21293
10.1038/nri.2017.90
10.1159/000475439
10.1002/ibd.20223
10.1111/j.1600-0625.2011.01304.x
10.1016/j.dld.2011.09.002
10.1016/j.immuni.2008.04.021
10.1016/s1074-7613(02)00283-2
10.1093/hmg/ddac269
10.1084/jem.20072528
10.1002/eji.201445213
10.1097/DCR.0000000000000274
10.1016/j.pupt.2017.08.012
10.4049/jimmunol.178.7.4033
10.1073/pnas.2120771120
10.3389/fimmu.2021.692127
10.3389/fimmu.2019.00583
10.1038/ajg.2008.36
10.1016/j.lfs.2020.118220
10.1002/eji.200535477
10.1371/journal.ppat.1006566
10.1111/apt.14853
10.1371/journal.pone.0060136
10.4049/jimmunol.1002374
10.1371/journal.pone.0114665
10.1096/fj.11-200618
10.1084/jem.20231236
10.1016/j.ajpath.2011.10.026
10.1016/j.clim.2004.02.007
10.1111/bcp.14187
10.3389/fimmu.2018.00362
10.1074/jbc.274.20.13733
10.1053/j.gastro.2004.11.053
10.1136/gutjnl-2023-329963
10.4049/jimmunol.1201908
10.1097/MIB.0000000000000512
10.4049/jimmunol.1502466
10.1016/j.mucimm.2024.03.006
10.1136/gutjnl-2014-308617
10.1371/journal.pone.0016090
10.4049/jimmunol.1301475
10.1038/mi.2014.37
10.1080/19490976.2019.1638725
10.1136/gut.2008.148908
10.1016/S0016-5085(23)04753-4
10.21873/cdp.10124
10.1136/gutjnl-2011-300777
10.1016/j.jcmgh.2020.08.003
10.1016/j.bcp.2011.01.011
10.1007/s10620-019-05580-z
10.1021/bi900031w
10.1038/25387
10.1136/gutjnl-2019-319706
10.1093/ecco-jcc/jjaa165
10.4049/jimmunol.172.11.7002
10.1093/ibd/izy305
10.1038/mi.2010.70
10.1097/MIB.0000000000000653
10.1371/journal.pone.0092743
10.1016/j.pharmthera.2013.06.009
10.4161/cc.2.6.566
10.1038/mi.2010.67
10.1002/1873-3468.12632
10.1158/0008-5472.CAN-05-4605
10.1093/hmg/ddi379
10.4049/jimmunol.2000665
10.4049/jimmunol.171.9.4868
10.1038/ng.3359
10.1093/ecco-jcc/jjad212.1128
10.1002/art.22494
10.1002/eji.201041950
10.1038/384372a0
10.1371/journal.pone.0022688
10.1002/eji.200839087
10.1189/jlb.3A0316-129R
10.1002/cyto.b.21372
10.1016/j.crohns.2014.04.002
10.1016/S1074-7613(02)00283-2
10.1172/JCI200419836
10.1016/S0378-1119(97)00509-X
10.1038/S41588-023-01384-0
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Keywords ULCERATIVE COLITIS
CROHN'S DISEASE
CYTOKINES
Language English
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crossref_citationtrail_10_1136_gutjnl_2024_332504
crossref_primary_10_1136_gutjnl_2024_332504
bmj_journals_10_1136_gutjnl_2024_332504
PublicationCentury 2000
PublicationDate 2025-04-01
PublicationDateYYYYMMDD 2025-04-01
PublicationDate_xml – month: 04
  year: 2025
  text: 2025-04-01
  day: 01
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Gut
PublicationTitleAbbrev Gut
PublicationTitleAlternate Gut
PublicationYear 2025
Publisher BMJ Publishing Group Ltd and British Society of Gastroenterology
BMJ Publishing Group LTD
Publisher_xml – name: BMJ Publishing Group Ltd and British Society of Gastroenterology
– name: BMJ Publishing Group LTD
References Tan, Harrop, Reddy (R11) 1997; 204
Hong, Park, Park (R44) 2016; 65
Yu, Pappu, Ramirez-Carrozzi (R93) 2014; 7
Bamias, Filidou, Goukos (R96) 2017; 180
Bamias, Martin, Mishina (R106) 2005; 128
Sands, Peyrin-Biroulet, Danese (R2) 2023; 164
Sessler, Healy, Samali (R22) 2013; 140
Menghini, Butto, Gomez-Nguyen (R73) 2024
Gieseck, Wilson, Wynn (R104) 2018; 18
Shih, Barrett, Zhang (R81) 2011; 6
Hayashi, Miura, Nishiyama (R119) 2007; 56
Rieder, Mukherjee, Massey (R95) 2024; 73
Thomas, Targan, Tsuda (R67) 2017; 101
Bittner, Knoll, Ehrenschwender (R75) 2017; 591
Khan, Tsai, Schreiber (R76) 2013; 190
Endo, Kakuta, Moroi (R55) 2020; 4
Meylan, Song, Fuss (R80) 2011; 4
Pham, O’Donnell, Al-Shamkhani (R88) 2017; 13
Masterson, Capocelli, Hosford (R108) 2015; 21
Pobezinskaya, Choksi, Morgan (R20) 2011; 186
Shih, Zheng, Zhang (R103) 2014; 7
Papadakis, Prehn, Landers (R34) 2004; 172
Chen, Lee, Bowcock (R49) 2011; 54
Serafini, Di Santo (R89) 2024; 323
Jin, Chin, Seeber (R33) 2013; 6
Singh, Perks, Twohig (R70) 2017; 320
Yamazaki, McGovern, Ragoussis (R36) 2005; 14
Ditrich, Blümel, Biedermann (R56) 2020; 13
Nakagome, Chinen, Iraha (R61) 2017; 136
Kokkotis, Filidou, Tarapatzi (R99) 2024
Buchan, Taraban, Slebioda (R86) 2012; 42
Migone, Zhang, Luo (R3) 2002; 16
Valatas, Kolios, Bamias (R50) 2019; 10
Hu, Vich Vila, Gacesa (R62) 2021; 70
Takedatsu, Michelsen, Wei (R8) 2008; 135
Pizarro, Pastorelli, Bamias (R79) 2011; 17
Thiébaut, Kotti, Jung (R39) 2009; 104
Liu, Liu, Gao (R43) 2023; 55
Lawrance, Rogler, Bamias (R105) 2017; 11
Yang, Yang, Song (R53) 2014; 8
Reinisch, Stoyanov, Raphael (R113) 2024; 18
Fayad, Brand, Stone (R120) 2006; 36
Zhan, Yan, Patskovsky (R12) 2009; 48
Zhao, Wang, Wu (R83) 2020; 48
Steele, Sachen, McKnight (R109) 2021; 12
Castellanos, Longman (R91) 2020; 11
Sidhu-Varma, Shih, Targan (R77) 2016; 22
Liu, Li, Gao (R116) 2014; 9
Twohig, Marsden, Cuff (R87) 2012; 26
Latiano, Palmieri, Latiano (R48) 2011; 6
Schmitt, Duval, Camus (R94) 2024; 221
Bu, Borysenko, Li (R19) 2003; 33
Jones, Stumhofer, Foster (R66) 2011; 25
Rieder, Bettenworth, Ma (R110) 2018; 48
Yang, Jia, Wang (R82) 2019; 64
Papadakis, Zhu, Prehn (R32) 2005; 174
Jacobs, Ke, Ceulemans (R107) 2024; 15
Feagan, Sands, Siegel (R112) 2023; 17
Funke, Autschbach, Kim (R121) 2009; 58
Zhang, Zhang, Wu (R35) 2014; 47
Bamias, Stamatelopoulos, Zampeli (R126) 2013; 147
Wen, Zhuang, Luo (R21) 2003; 278
Bamias, Mishina, Nyce (R7) 2006; 103
Bamias, Kaltsa, Siakavellas (R118) 2010; 137
Fukaya, Uto, Mitoma (R92) 2023; 42
Cordero, Cordero, Stiemke (R45) 2023; 32
Prehn, Thomas, Landers (R30) 2007; 178
Niese, Pajulas, Rostron (R72) 2024; 17
Nalleweg, Chiriac, Podstawa (R74) 2015; 64
Baskaran, Pugazhendhi, Ramakrishna (R38) 2014; 9
Kitson, Raven, Jiang (R4) 1996; 384
Cleynen, González, Figueroa (R52) 2013; 62
Lin, Hsieh (R25) 2011; 81
Lagou, Grapsa, Syrigos (R27) 2022; 2
Bamias, Siakavellas, Stamatelopoulos (R123) 2008; 129
Michelsen, Thomas, Taylor (R58) 2009; 4
Ye, Choi, Hong (R40) 2016; 22
Fuss, Heller, Boirivant (R71) 2004; 113
Haritunians, Taylor, Targan (R57) 2010; 16
Hirano, Yamazaki, Umeno (R54) 2013; 19
Danese, Klopocka, Scherl (R1) 2021; 19
Bamias, Kaltsa, Siakavellas (R117) 2012; 44
Képíró, Széll, Kovács (R125) 2014; 75
Pappu, Borodovsky, Zheng (R64) 2008; 205
Herro, Miki, Sethi (R98) 2020; 205
Meylan, Davidson, Kahle (R69) 2008; 29
Meng, Jiang, Wang (R68) 2023; 120
Shih, Kwan, Chavez (R85) 2009; 39
Slebioda, Bojarska-Junak, Cyman (R122) 2017; 92
Hedl, Abraham (R24) 2014; 111
Connelly, Berg, Harris (R47) 2015; 58
Hassan-Zahraee, Ye, Xi (R100) 2022; 28
Han, Song, Jia (R65) 2020; 262
Prehn, Mehdizadeh, Landers (R28) 2004; 112
Banfield, Rudin, Bhattacharya (R111) 2020; 86
Buttó, Jia, Arseneau (R114) 2019; 25
Picornell, Mei, Taylor (R37) 2007; 13
Bamias, Evangelou, Vergou (R124) 2011; 20
Bouros, Filidou, Arvanitidis (R97) 2017; 46
Barrett, Zhang, Koon (R102) 2012; 180
Bamias, Martin, Marini (R6) 2003; 171
Yu, Kwon, Ni (R26) 1999; 274
Wang, Al-Lamki, Zhu (R18) 2014; 15
Sun, Hedl, Abraham (R60) 2021; 11
Wang, Hu, Charpentier (R17) 2013; 191
Pai, Weng, Wei (R29) 2020; 15
Cavallini, Lovato, Bertolaso (R16) 2013; 8
Kakuta, Ueki, Kinouchi (R59) 2009; 18
Li, Buttó, Buela (R78) 2018; 9
Zheng, Zhang, Chen (R101) 2013; 3
Gout, Morin, Houle (R115) 2006; 66
Chinnaiyan, O’Rourke, Yu (R13) 1996; 274
Castellanos, Woo, Viladomiu (R31) 2018; 49
Pitti, Marsters, Lawrence (R5) 1998; 396
Shimodaira, More, Hamade (R84) 2023; 16
Fang, Adkins, Deyev (R15) 2008; 205
Sheikh, Huang (R23) 2003; 2
Jia, Bamias, Arseneau (R10) 2016; 197
Richard, Peters, Savinykh (R63) 2018; 14
Zucchelli, Camilleri, Andreasson (R51) 2011; 60
Liu, van Sommeren, Huang (R42) 2015; 47
Taraban, Slebioda, Willoughby (R9) 2011; 4
Lee, Kim, Jang (R41) 2015; 57
Lan, Lan, Chang (R46) 2017; 41
Screaton, Xu, Olsen (R14) 1997; 94
Ahn, Weeres, Neulen (R90) 2015; 45
2025041509001196000_74.4.652.115
2025041509001196000_74.4.652.114
Baskaran (2025041509001196000_74.4.652.38) 2014; 9
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2025041509001196000_74.4.652.111
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2025041509001196000_74.4.652.71
2025041509001196000_74.4.652.70
Meng (2025041509001196000_74.4.652.68) 2023; 120
Michelsen (2025041509001196000_74.4.652.58) 2009; 4
Lawrance (2025041509001196000_74.4.652.105) 2017; 11
2025041509001196000_74.4.652.119
2025041509001196000_74.4.652.118
Sheikh (2025041509001196000_74.4.652.23) 2003; 2
2025041509001196000_74.4.652.126
Valatas (2025041509001196000_74.4.652.50) 2019; 10
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2025041509001196000_74.4.652.124
Wang (2025041509001196000_74.4.652.18) 2014; 15
2025041509001196000_74.4.652.66
2025041509001196000_74.4.652.123
2025041509001196000_74.4.652.65
Pham (2025041509001196000_74.4.652.88) 2017; 13
2025041509001196000_74.4.652.64
2025041509001196000_74.4.652.120
2025041509001196000_74.4.652.62
2025041509001196000_74.4.652.61
2025041509001196000_74.4.652.60
Latiano (2025041509001196000_74.4.652.48) 2011; 6
Pai (2025041509001196000_74.4.652.29) 2020; 15
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2025041509001196000_74.4.652.92
2025041509001196000_74.4.652.91
Cavallini (2025041509001196000_74.4.652.16) 2013; 8
2025041509001196000_74.4.652.19
Liu (2025041509001196000_74.4.652.116) 2014; 9
2025041509001196000_74.4.652.104
2025041509001196000_74.4.652.103
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Steele (2025041509001196000_74.4.652.109) 2021; 12
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Li (2025041509001196000_74.4.652.78) 2018; 9
Sands (2025041509001196000_74.4.652.2) 2023; 164
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Masterson (2025041509001196000_74.4.652.108) 2015; 21
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Richard (2025041509001196000_74.4.652.63) 2018; 14
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References_xml – volume: 17
  start-page: 2566
  year: 2011
  ident: R79
  article-title: SAMP1/YitFc mouse strain: a spontaneous model of Crohn’s disease-like ileitis
  publication-title: Inflamm Bowel Dis
  doi: 10.1002/ibd.21638
– volume: 19
  start-page: 2324
  year: 2021
  ident: R1
  article-title: Anti-TL1A Antibody PF-06480605 Safety and Efficacy for Ulcerative Colitis: A Phase 2a Single-Arm Study
  publication-title: Clin Gastroenterol Hepatol
  doi: 10.1016/j.cgh.2021.06.011
– volume: 205
  start-page: 1049
  year: 2008
  ident: R64
  article-title: TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease
  publication-title: J Exp Med
  doi: 10.1084/jem.20071364
– volume: 113
  start-page: 1490
  year: 2004
  ident: R71
  article-title: Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
  publication-title: J Clin Invest
  doi: 10.1172/JCI19836
– volume: 60
  start-page: 1671
  year: 2011
  ident: R51
  article-title: Association of TNFSF15 polymorphism with irritable bowel syndrome
  publication-title: Gut
  doi: 10.1136/gut.2011.241877
– volume: 17
  start-page: i162
  year: 2023
  ident: R112
  article-title: DOP87 the anti-TL1A antibody PRA023 demonstrated proof-of-concept in Crohn’s Disease: phase 2a APOLLO-CD study results
  publication-title: J Crohn's Colitis
  doi: 10.1093/ecco-jcc/jjac190.0127
– volume: 111
  start-page: 13451
  year: 2014
  ident: R24
  article-title: A TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1404178111
– volume: 25
  start-page: 409
  year: 2011
  ident: R66
  article-title: Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation
  publication-title: FASEB J
  doi: 10.1096/fj.10-166843
– volume: 103
  start-page: 8441
  year: 2006
  ident: R7
  article-title: Role of TL1A and its receptor DR3 in two models of chronic murine ileitis
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0510903103
– volume: 135
  start-page: 552
  year: 2008
  ident: R8
  article-title: TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2008.04.037
– volume: 28
  start-page: 434
  year: 2022
  ident: R100
  article-title: Antitumor Necrosis Factor-like Ligand 1A Therapy Targets Tissue Inflammation and Fibrosis Pathways and Reduces Gut Pathobionts in Ulcerative Colitis
  publication-title: Inflamm Bowel Dis
  doi: 10.1093/ibd/izab193
– volume: 6
  start-page: 886
  year: 2013
  ident: R33
  article-title: TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNFα, from CD3+CD161+ T cells to exacerbate gut inflammation
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2012.124
– volume: 57
  start-page: 1149
  year: 2015
  ident: R41
  article-title: Association of TNFSF15 polymorphisms in Korean children with Crohn’s disease
  publication-title: Pediatr Int
  doi: 10.1111/ped.12686
– volume: 19
  start-page: 526
  year: 2013
  ident: R54
  article-title: Association study of 71 European Crohn’s disease susceptibility loci in a Japanese population
  publication-title: Inflamm Bowel Dis
  doi: 10.1097/MIB.0b013e31828075e7
– volume: 147
  start-page: 144
  year: 2013
  ident: R126
  article-title: Circulating levels of TNF-like cytokine 1A correlate with the progression of atheromatous lesions in patients with rheumatoid arthritis
  publication-title: Clin Immunol
  doi: 10.1016/j.clim.2013.03.002
– volume: 323
  start-page: 126
  year: 2024
  ident: R89
  article-title: Group 3 innate lymphoid cells: A trained Gutkeeper
  publication-title: Immunol Rev
  doi: 10.1111/imr.13322
– volume: 47
  start-page: 512
  year: 2014
  ident: R35
  article-title: Associations between TNFSF15 polymorphisms and susceptibility to ulcerative colitis and Crohn’s disease: A meta-analysis
  publication-title: Autoimmunity
  doi: 10.3109/08916934.2014.930735
– volume: 49
  start-page: 1077
  year: 2018
  ident: R31
  article-title: Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis
  publication-title: Immunity
  doi: 10.1016/j.immuni.2018.10.014
– volume: 75
  start-page: 159
  year: 2014
  ident: R125
  article-title: Genetic risk and protective factors of TNFSF15 gene variants detected using single nucleotide polymorphisms in Hungarians with psoriasis and psoriatic arthritis
  publication-title: Hum Immunol
  doi: 10.1016/j.humimm.2013.11.006
– volume: 14
  year: 2018
  ident: R63
  article-title: Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1007458
– year: 2024
  ident: R73
  publication-title: bioRxiv
  doi: 10.1101/2024.02.09.579684
– year: 2024
  ident: R99
  article-title: Oncostatin M Induces a Pro-inflammatory Phenotype in Intestinal Subepithelial Myofibroblasts
  publication-title: Inflamm Bowel Dis
  doi: 10.1093/ibd/izae098
– volume: 42
  start-page: 112431
  year: 2023
  ident: R92
  article-title: Gut dysbiosis promotes the breakdown of oral tolerance mediated through dysfunction of mucosal dendritic cells
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2023.112431
– volume: 55
  start-page: 796
  year: 2023
  ident: R43
  article-title: Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries
  publication-title: Nat Genet
  doi: 10.1038/s41588-023-01384-0
– volume: 48
  year: 2020
  ident: R83
  article-title: Tumor necrosis factor ligand-related molecule 1A affects the intestinal mucosal barrier function by promoting Th9/interleukin-9 expression
  publication-title: J Int Med Res
  doi: 10.1177/0300060520926011
– volume: 13
  year: 2020
  ident: R56
  article-title: Genetic risk factors predict disease progression in Crohn’s disease patients of the Swiss inflammatory bowel disease cohort
  publication-title: Therap Adv Gastroenterol
  doi: 10.1177/1756284820959252
– volume: 16
  start-page: 83
  year: 2023
  ident: R84
  article-title: DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury
  publication-title: Cell Mol Gastroenterol Hepatol
  doi: 10.1016/j.jcmgh.2023.03.008
– volume: 4
  year: 2009
  ident: R58
  article-title: IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0004719
– volume: 18
  start-page: 1089
  year: 2009
  ident: R59
  article-title: TNFSF15 transcripts from risk haplotype for Crohn’s disease are overexpressed in stimulated T cells
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddp005
– volume: 274
  start-page: 990
  year: 1996
  ident: R13
  article-title: Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95
  publication-title: Science
  doi: 10.1126/science.274.5289.990
– volume: 320
  start-page: 62
  year: 2017
  ident: R70
  article-title: Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation
  publication-title: Cell Immunol
  doi: 10.1016/j.cellimm.2017.09.005
– volume: 174
  start-page: 4985
  year: 2005
  ident: R32
  article-title: Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes
  publication-title: J Immunol
  doi: 10.4049/jimmunol.174.8.4985
– volume: 64
  start-page: 743
  year: 2015
  ident: R74
  article-title: IL-9 and its receptor are predominantly involved in the pathogenesis of UC
  publication-title: Gut
  doi: 10.1136/gutjnl-2013-305947
– volume: 180
  start-page: 118
  year: 2017
  ident: R96
  article-title: Crohn’s disease-associated mucosal factors regulate the expression of TNF-like cytokine 1A and its receptors in primary subepithelial intestinal myofibroblasts and intestinal epithelial cells
  publication-title: Transl Res
  doi: 10.1016/j.trsl.2016.08.007
– volume: 15
  year: 2024
  ident: R107
  article-title: Fibrostricturing Crohn’s Disease Is Marked by an Increase in Active Eosinophils in the Deeper Layers
  publication-title: Clin Transl Gastroenterol
  doi: 10.14309/ctg.0000000000000706
– volume: 7
  start-page: 730
  year: 2014
  ident: R93
  article-title: TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2013.92
– volume: 22
  start-page: 13
  year: 2016
  ident: R40
  article-title: Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans
  publication-title: Inflamm Bowel Dis
  doi: 10.1097/MIB.0000000000000584
– volume: 129
  start-page: 249
  year: 2008
  ident: R123
  article-title: Circulating levels of TNF-like cytokine 1A (TL1A) and its decoy receptor 3 (DcR3) in rheumatoid arthritis
  publication-title: Clin Immunol
  doi: 10.1016/j.clim.2008.07.014
– volume: 204
  start-page: 35
  year: 1997
  ident: R11
  article-title: Characterization of a novel TNF-like ligand and recently described TNF ligand and TNF receptor superfamily genes and their constitutive and inducible expression in hematopoietic and non-hematopoietic cells
  publication-title: Gene
  doi: 10.1016/s0378-1119(97)00509-x
– volume: 137
  start-page: 242
  year: 2010
  ident: R118
  article-title: High intestinal and systemic levels of decoy receptor 3 (DcR3) and its ligand TL1A in active ulcerative colitis
  publication-title: Clin Immunol
  doi: 10.1016/j.clim.2010.07.001
– volume: 278
  start-page: 39251
  year: 2003
  ident: R21
  article-title: TL1A-induced NF-kappaB activation and c-IAP2 production prevent DR3-mediated apoptosis in TF-1 cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M305833200
– volume: 4
  start-page: 1108
  year: 2020
  ident: R55
  article-title: TL1A (TNFSF15) genotype affects the long-term therapeutic outcomes of anti-TNFα antibodies for Crohn’s disease patients
  publication-title: JGH Open
  doi: 10.1002/jgh3.12398
– volume: 94
  start-page: 4615
  year: 1997
  ident: R14
  article-title: LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.94.9.4615
– volume: 33
  start-page: 760
  year: 2003
  ident: R19
  article-title: Expression and function of TNF-family proteins and receptors in human osteoblasts
  publication-title: Bone
  doi: 10.1016/j.bone.2003.07.006
– volume: 15
  year: 2014
  ident: R18
  article-title: TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells
  publication-title: BMC Nephrol
  doi: 10.1186/1471-2369-15-178
– volume: 3
  start-page: 11
  year: 2013
  ident: R101
  article-title: SUSTAINED TL1A (TNFSF15) EXPRESSION ON BOTH LYMPHOID AND MYELOID CELLS LEADS TO MILD SPONTANEOUS INTESTINAL INFLAMMATION AND FIBROSIS
  publication-title: Eur J Microbiol Immunol (Bp)
  doi: 10.1556/EuJMI.3.2013.1.2
– volume: 136
  start-page: 387
  year: 2017
  ident: R61
  article-title: Confounding effects of microbiome on the susceptibility of TNFSF15 to Crohn’s disease in the Ryukyu Islands
  publication-title: Hum Genet
  doi: 10.1007/s00439-017-1764-0
– volume: 11
  start-page: 1491
  year: 2017
  ident: R105
  article-title: Cellular and Molecular Mediators of Intestinal Fibrosis
  publication-title: J Crohns Colitis
  doi: 10.1016/j.crohns.2014.09.008
– volume: 54
  start-page: 1020
  year: 2011
  ident: R49
  article-title: Influence of Crohn’s disease risk alleles and smoking on disease location
  publication-title: Dis Colon Rectum
  doi: 10.1007/DCR.0b013e31821b94b3
– volume: 16
  start-page: 1830
  year: 2010
  ident: R57
  article-title: Genetic predictors of medically refractory ulcerative colitis
  publication-title: Inflamm Bowel Dis
  doi: 10.1002/ibd.21293
– volume: 18
  start-page: 62
  year: 2018
  ident: R104
  article-title: Type 2 immunity in tissue repair and fibrosis
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri.2017.90
– volume: 41
  start-page: 2077
  year: 2017
  ident: R46
  article-title: Identification of Two Additional Susceptibility Loci for Inflammatory Bowel Disease in a Chinese Population
  publication-title: Cell Physiol Biochem
  doi: 10.1159/000475439
– volume: 13
  start-page: 1333
  year: 2007
  ident: R37
  article-title: TNFSF15 is an ethnic-specific IBD gene
  publication-title: Inflamm Bowel Dis
  doi: 10.1002/ibd.20223
– volume: 20
  start-page: 725
  year: 2011
  ident: R124
  article-title: Upregulation and nuclear localization of TNF-like cytokine 1A (TL1A) and its receptors DR3 and DcR3 in psoriatic skin lesions
  publication-title: Exp Dermatol
  doi: 10.1111/j.1600-0625.2011.01304.x
– volume: 44
  start-page: 30
  year: 2012
  ident: R117
  article-title: Differential expression of the TL1A/DcR3 system of TNF/TNFR-like proteins in large vs. small intestinal Crohn’s disease
  publication-title: Dig Liver Dis
  doi: 10.1016/j.dld.2011.09.002
– volume: 29
  start-page: 79
  year: 2008
  ident: R69
  article-title: The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases
  publication-title: Immunity
  doi: 10.1016/j.immuni.2008.04.021
– volume: 16
  start-page: 479
  year: 2002
  ident: R3
  article-title: TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator
  publication-title: Immunity
  doi: 10.1016/s1074-7613(02)00283-2
– volume: 32
  start-page: 873
  year: 2023
  ident: R45
  article-title: Trans-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddac269
– volume: 205
  start-page: 1037
  year: 2008
  ident: R15
  article-title: Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation
  publication-title: J Exp Med
  doi: 10.1084/jem.20072528
– volume: 45
  start-page: 2335
  year: 2015
  ident: R90
  article-title: Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201445213
– volume: 58
  start-page: 321
  year: 2015
  ident: R47
  article-title: Genetic determinants associated with early age of diagnosis of IBD
  publication-title: Dis Colon Rectum
  doi: 10.1097/DCR.0000000000000274
– volume: 46
  start-page: 78
  year: 2017
  ident: R97
  article-title: Lung fibrosis-associated soluble mediators and bronchoalveolar lavage from idiopathic pulmonary fibrosis patients promote the expression of fibrogenic factors in subepithelial lung myofibroblasts
  publication-title: Pulm Pharmacol Ther
  doi: 10.1016/j.pupt.2017.08.012
– volume: 178
  start-page: 4033
  year: 2007
  ident: R30
  article-title: The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.178.7.4033
– volume: 120
  year: 2023
  ident: R68
  article-title: Tumor necrosis factor-like cytokine 1A plays a role in inflammatory bowel disease pathogenesis
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2120771120
– volume: 12
  year: 2021
  ident: R109
  article-title: Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Rα in Muco-Secretory Fibrotic Disorders
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.692127
– volume: 10
  year: 2019
  ident: R50
  article-title: TL1A (TNFSF15) and DR3 (TNFRSF25): A Co-stimulatory System of Cytokines With Diverse Functions in Gut Mucosal Immunity
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2019.00583
– volume: 104
  start-page: 384
  year: 2009
  ident: R39
  article-title: TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European cohort
  publication-title: Am J Gastroenterol
  doi: 10.1038/ajg.2008.36
– volume: 262
  start-page: 118220
  year: 2020
  ident: R65
  article-title: TL1A primed dendritic cells activation exacerbated chronic murine colitis
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2020.118220
– volume: 36
  start-page: 2215
  year: 2006
  ident: R120
  article-title: Apoptosis resistance in ulcerative colitis: high expression of decoy receptors by lamina propria T cells
  publication-title: Eur J Immunol
  doi: 10.1002/eji.200535477
– volume: 13
  year: 2017
  ident: R88
  article-title: T cell expression of IL-18R and DR3 is essential for non-cognate stimulation of Th1 cells and optimal clearance of intracellular bacteria
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1006566
– volume: 48
  start-page: 347
  year: 2018
  ident: R110
  article-title: An expert consensus to standardise definitions, diagnosis and treatment targets for anti-fibrotic stricture therapies in Crohn’s disease
  publication-title: Aliment Pharmacol Ther
  doi: 10.1111/apt.14853
– volume: 8
  year: 2013
  ident: R16
  article-title: The TNF-family cytokine TL1A inhibits proliferation of human activated B cells
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0060136
– volume: 186
  start-page: 5212
  year: 2011
  ident: R20
  article-title: The adaptor protein TRADD is essential for TNF-like ligand 1A/death receptor 3 signaling
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1002374
– volume: 9
  year: 2014
  ident: R38
  article-title: Protective association of tumor necrosis factor superfamily 15 (TNFSF15) polymorphic haplotype with Ulcerative Colitis and Crohn’s disease in an Indian population
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0114665
– volume: 26
  start-page: 3575
  year: 2012
  ident: R87
  article-title: The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity
  publication-title: FASEB J
  doi: 10.1096/fj.11-200618
– volume: 221
  year: 2024
  ident: R94
  article-title: TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation
  publication-title: J Exp Med
  doi: 10.1084/jem.20231236
– volume: 180
  start-page: 636
  year: 2012
  ident: R102
  article-title: Constitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis
  publication-title: Am J Pathol
  doi: 10.1016/j.ajpath.2011.10.026
– volume: 112
  start-page: 66
  year: 2004
  ident: R28
  article-title: Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation
  publication-title: Clin Immunol
  doi: 10.1016/j.clim.2004.02.007
– volume: 86
  start-page: 812
  year: 2020
  ident: R111
  article-title: First-in-human, randomized dose-escalation study of the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of PF-06480605 in healthy subjects
  publication-title: Br J Clin Pharmacol
  doi: 10.1111/bcp.14187
– volume: 9
  year: 2018
  ident: R78
  article-title: Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn’s Disease-Like Ileitis
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.00362
– volume: 274
  start-page: 13733
  year: 1999
  ident: R26
  article-title: A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.20.13733
– volume: 128
  start-page: 654
  year: 2005
  ident: R106
  article-title: Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2004.11.053
– volume: 73
  start-page: 854
  year: 2024
  ident: R95
  article-title: Fibrosis in IBD: from pathogenesis to therapeutic targets
  publication-title: Gut
  doi: 10.1136/gutjnl-2023-329963
– volume: 190
  start-page: 1540
  year: 2013
  ident: R76
  article-title: Cloning, expression, and functional characterization of TL1A-Ig
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1201908
– volume: 21
  start-page: 2429
  year: 2015
  ident: R108
  article-title: Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn’s Ileitis
  publication-title: Inflamm Bowel Dis
  doi: 10.1097/MIB.0000000000000512
– volume: 197
  start-page: 377
  year: 2016
  ident: R10
  article-title: A Novel Role for TL1A/DR3 in Protection against Intestinal Injury and Infection
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1502466
– volume: 17
  start-page: 537
  year: 2024
  ident: R72
  article-title: TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma
  publication-title: Muc Immunol
  doi: 10.1016/j.mucimm.2024.03.006
– volume: 65
  start-page: 788
  year: 2016
  ident: R44
  article-title: Deep resequencing of 131 Crohn’s disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants
  publication-title: Gut
  doi: 10.1136/gutjnl-2014-308617
– volume: 6
  year: 2011
  ident: R81
  article-title: Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0016090
– volume: 191
  start-page: 5420
  year: 2013
  ident: R17
  article-title: TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1301475
– volume: 7
  start-page: 1492
  year: 2014
  ident: R103
  article-title: Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2014.37
– volume: 11
  start-page: 231
  year: 2020
  ident: R91
  article-title: Innate lymphoid cells link gut microbes with mucosal T cell immunity
  publication-title: Gut Microbes
  doi: 10.1080/19490976.2019.1638725
– volume: 58
  start-page: 483
  year: 2009
  ident: R121
  article-title: Functional characterisation of decoy receptor 3 in Crohn’s disease
  publication-title: Gut
  doi: 10.1136/gut.2008.148908
– volume: 164
  start-page: S
  year: 2023
  ident: R2
  article-title: 477a a phase 2, randomized, double-blind, placebo-controlled trial of PRA023 as induction therapy in patients with moderately to severely active ulcerative colitis: artemisuc, cohort 1
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(23)04753-4
– volume: 2
  start-page: 411
  year: 2022
  ident: R27
  article-title: The Role of Decoy Receptor DcR3 in Gastrointestinal Malignancy
  publication-title: Cancer Diagn Progn
  doi: 10.21873/cdp.10124
– volume: 62
  start-page: 1556
  year: 2013
  ident: R52
  article-title: Genetic factors conferring an increased susceptibility to develop Crohn’s disease also influence disease phenotype: results from the IBDchip European Project
  publication-title: Gut
  doi: 10.1136/gutjnl-2011-300777
– volume: 11
  start-page: 249
  year: 2021
  ident: R60
  article-title: TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants
  publication-title: Cell Mol Gastroenterol Hepatol
  doi: 10.1016/j.jcmgh.2020.08.003
– volume: 81
  start-page: 838
  year: 2011
  ident: R25
  article-title: Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2011.01.011
– volume: 64
  start-page: 1844
  year: 2019
  ident: R82
  article-title: Effects and Mechanism of Constitutive TL1A Expression on Intestinal Mucosal Barrier in DSS-Induced Colitis
  publication-title: Dig Dis Sci
  doi: 10.1007/s10620-019-05580-z
– volume: 48
  start-page: 7636
  year: 2009
  ident: R12
  article-title: Biochemical and structural characterization of the human TL1A ectodomain
  publication-title: Biochemistry
  doi: 10.1021/bi900031w
– volume: 396
  start-page: 699
  year: 1998
  ident: R5
  article-title: Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
  publication-title: Nature New Biol
  doi: 10.1038/25387
– volume: 70
  start-page: 285
  year: 2021
  ident: R62
  article-title: Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD
  publication-title: Gut
  doi: 10.1136/gutjnl-2019-319706
– volume: 15
  start-page: 258
  year: 2020
  ident: R29
  article-title: Gut microbial transcytosis induced by tumor necrosis factor-like 1A-dependent activation of a myosin light chain kinase splice variant contributes to IBD
  publication-title: J Crohns Colitis
  doi: 10.1093/ecco-jcc/jjaa165
– volume: 172
  start-page: 7002
  year: 2004
  ident: R34
  article-title: TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.11.7002
– volume: 25
  start-page: 14
  year: 2019
  ident: R114
  article-title: Death-Domain-Receptor 3 Deletion Normalizes Inflammatory Gene Expression and Prevents Ileitis in Experimental Crohn’s Disease
  publication-title: Inflamm Bowel Dis
  doi: 10.1093/ibd/izy305
– volume: 4
  start-page: 186
  year: 2011
  ident: R9
  article-title: Sustained TL1A expression modulates effector and regulatory T-cell responses and drives intestinal goblet cell hyperplasia
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2010.70
– volume: 22
  start-page: 548
  year: 2016
  ident: R77
  article-title: Differential Levels of Tl1a Affect the Expansion and Function of Regulatory T Cells in Modulating Murine Colitis
  publication-title: Inflamm Bowel Dis
  doi: 10.1097/MIB.0000000000000653
– volume: 9
  year: 2014
  ident: R116
  article-title: Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0092743
– volume: 140
  start-page: 186
  year: 2013
  ident: R22
  article-title: Structural determinants of DISC function: new insights into death receptor-mediated apoptosis signalling
  publication-title: Pharmacol Ther
  doi: 10.1016/j.pharmthera.2013.06.009
– volume: 2
  start-page: 550
  year: 2003
  ident: R23
  article-title: Death receptor activation complexes: it takes two to activate TNF receptor 1
  publication-title: Cell Cycle
  doi: 10.4161/cc.2.6.566
– volume: 4
  start-page: 172
  year: 2011
  ident: R80
  article-title: The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2010.67
– volume: 591
  start-page: 1187
  year: 2017
  ident: R75
  article-title: Death receptor 3 signaling enhances proliferation of human regulatory T cells
  publication-title: FEBS Lett
  doi: 10.1002/1873-3468.12632
– volume: 66
  start-page: 9117
  year: 2006
  ident: R115
  article-title: Death receptor-3, a new E-Selectin counter-receptor that confers migration and survival advantages to colon carcinoma cells by triggering p38 and ERK MAPK activation
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-05-4605
– volume: 14
  start-page: 3499
  year: 2005
  ident: R36
  article-title: Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn’s disease
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddi379
– volume: 205
  start-page: 2414
  year: 2020
  ident: R98
  article-title: TL1A Promotes Lung Tissue Fibrosis and Airway Remodeling
  publication-title: J Immunol
  doi: 10.4049/jimmunol.2000665
– volume: 171
  start-page: 4868
  year: 2003
  ident: R6
  article-title: Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease
  publication-title: J Immunol
  doi: 10.4049/jimmunol.171.9.4868
– volume: 47
  start-page: 979
  year: 2015
  ident: R42
  article-title: Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
  publication-title: Nat Genet
  doi: 10.1038/ng.3359
– volume: 18
  year: 2024
  ident: R113
  article-title: P998 Phase 2 basket design study evaluating the efficacy and safety of an anti-TL1A antibody (TEV-48574) in moderate to severe ulcerative colitis or Crohn’s Disease (RELIEVE UCCD)
  publication-title: J Crohn's Colitis
  doi: 10.1093/ecco-jcc/jjad212.1128
– volume: 56
  start-page: 1067
  year: 2007
  ident: R119
  article-title: Decoy receptor 3 expressed in rheumatoid synovial fibroblasts protects the cells against Fas-induced apoptosis
  publication-title: Arthritis Rheum
  doi: 10.1002/art.22494
– volume: 42
  start-page: 580
  year: 2012
  ident: R86
  article-title: Death receptor 3 is essential for generating optimal protective CD4+ T-cell immunity against Salmonella
  publication-title: Eur J Immunol
  doi: 10.1002/eji.201041950
– volume: 384
  start-page: 372
  year: 1996
  ident: R4
  article-title: A death-domain-containing receptor that mediates apoptosis
  publication-title: Nature New Biol
  doi: 10.1038/384372a0
– volume: 6
  year: 2011
  ident: R48
  article-title: Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0022688
– volume: 39
  start-page: 3239
  year: 2009
  ident: R85
  article-title: Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells
  publication-title: Eur J Immunol
  doi: 10.1002/eji.200839087
– volume: 101
  start-page: 727
  year: 2017
  ident: R67
  article-title: The TNF family member TL1A induces IL-22 secretion in committed human Th17 cells via IL-9 induction
  publication-title: J Leukoc Biol
  doi: 10.1189/jlb.3A0316-129R
– volume: 92
  start-page: 165
  year: 2017
  ident: R122
  article-title: Expression of death receptor 3 on peripheral blood mononuclear cells differes in adult IBD patients and children with newly diagnosed IBD
  publication-title: Cytometry B Clin Cytom
  doi: 10.1002/cyto.b.21372
– volume: 8
  start-page: 1315
  year: 2014
  ident: R53
  article-title: TNFSF15 is an independent predictor for the development of Crohn’s disease-related complications in Koreans
  publication-title: J Crohns Colitis
  doi: 10.1016/j.crohns.2014.04.002
– ident: 2025041509001196000_74.4.652.15
  doi: 10.1084/jem.20072528
– ident: 2025041509001196000_74.4.652.103
  doi: 10.1038/mi.2014.37
– ident: 2025041509001196000_74.4.652.5
  doi: 10.1038/25387
– ident: 2025041509001196000_74.4.652.90
  doi: 10.1002/eji.201445213
– ident: 2025041509001196000_74.4.652.35
  doi: 10.3109/08916934.2014.930735
– volume: 13
  year: 2020
  ident: 2025041509001196000_74.4.652.56
  article-title: Genetic risk factors predict disease progression in Crohn’s disease patients of the Swiss inflammatory bowel disease cohort
  publication-title: Therap Adv Gastroenterol
  doi: 10.1177/1756284820959252
– ident: 2025041509001196000_74.4.652.125
  doi: 10.1016/j.humimm.2013.11.006
– ident: 2025041509001196000_74.4.652.104
  doi: 10.1038/nri.2017.90
– ident: 2025041509001196000_74.4.652.106
  doi: 10.1053/j.gastro.2004.11.053
– ident: 2025041509001196000_74.4.652.69
  doi: 10.1016/j.immuni.2008.04.021
– ident: 2025041509001196000_74.4.652.118
  doi: 10.1016/j.clim.2010.07.001
– ident: 2025041509001196000_74.4.652.22
  doi: 10.1016/j.pharmthera.2013.06.009
– ident: 2025041509001196000_74.4.652.99
  doi: 10.1093/ibd/izae098
– ident: 2025041509001196000_74.4.652.124
  doi: 10.1111/j.1600-0625.2011.01304.x
– ident: 2025041509001196000_74.4.652.28
  doi: 10.1016/j.clim.2004.02.007
– ident: 2025041509001196000_74.4.652.20
  doi: 10.4049/jimmunol.1002374
– ident: 2025041509001196000_74.4.652.98
  doi: 10.4049/jimmunol.2000665
– ident: 2025041509001196000_74.4.652.36
  doi: 10.1093/hmg/ddi379
– ident: 2025041509001196000_74.4.652.89
  doi: 10.1111/imr.13322
– volume: 15
  year: 2014
  ident: 2025041509001196000_74.4.652.18
  article-title: TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells
  publication-title: BMC Nephrol
  doi: 10.1186/1471-2369-15-178
– ident: 2025041509001196000_74.4.652.8
  doi: 10.1053/j.gastro.2008.04.037
– ident: 2025041509001196000_74.4.652.62
  doi: 10.1136/gutjnl-2019-319706
– ident: 2025041509001196000_74.4.652.96
  doi: 10.1016/j.trsl.2016.08.007
– ident: 2025041509001196000_74.4.652.97
  doi: 10.1016/j.pupt.2017.08.012
– ident: 2025041509001196000_74.4.652.72
  doi: 10.1016/j.mucimm.2024.03.006
– ident: 2025041509001196000_74.4.652.92
  doi: 10.1016/j.celrep.2023.112431
– volume: 11
  start-page: 1491
  year: 2017
  ident: 2025041509001196000_74.4.652.105
  article-title: Cellular and Molecular Mediators of Intestinal Fibrosis
  publication-title: J Crohns Colitis
– ident: 2025041509001196000_74.4.652.84
  doi: 10.1016/j.jcmgh.2023.03.008
– ident: 2025041509001196000_74.4.652.37
  doi: 10.1002/ibd.20223
– ident: 2025041509001196000_74.4.652.65
  doi: 10.1016/j.lfs.2020.118220
– ident: 2025041509001196000_74.4.652.30
  doi: 10.4049/jimmunol.178.7.4033
– ident: 2025041509001196000_74.4.652.9
  doi: 10.1038/mi.2010.70
– ident: 2025041509001196000_74.4.652.57
  doi: 10.1002/ibd.21293
– ident: 2025041509001196000_74.4.652.87
  doi: 10.1096/fj.11-200618
– ident: 2025041509001196000_74.4.652.64
  doi: 10.1084/jem.20071364
– ident: 2025041509001196000_74.4.652.61
  doi: 10.1007/s00439-017-1764-0
– ident: 2025041509001196000_74.4.652.49
  doi: 10.1007/DCR.0b013e31821b94b3
– ident: 2025041509001196000_74.4.652.54
  doi: 10.1097/MIB.0b013e31828075e7
– ident: 2025041509001196000_74.4.652.14
  doi: 10.1073/pnas.94.9.4615
– ident: 2025041509001196000_74.4.652.52
  doi: 10.1136/gutjnl-2011-300777
– ident: 2025041509001196000_74.4.652.70
  doi: 10.1016/j.cellimm.2017.09.005
– ident: 2025041509001196000_74.4.652.12
  doi: 10.1021/bi900031w
– ident: 2025041509001196000_74.4.652.117
  doi: 10.1016/j.dld.2011.09.002
– ident: 2025041509001196000_74.4.652.95
  doi: 10.1136/gutjnl-2023-329963
– volume: 9
  year: 2014
  ident: 2025041509001196000_74.4.652.38
  article-title: Protective association of tumor necrosis factor superfamily 15 (TNFSF15) polymorphic haplotype with Ulcerative Colitis and Crohn’s disease in an Indian population
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0114665
– volume: 9
  year: 2014
  ident: 2025041509001196000_74.4.652.116
  article-title: Progranulin-derived Atsttrin directly binds to TNFRSF25 (DR3) and inhibits TNF-like ligand 1A (TL1A) activity
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0092743
– volume: 4
  year: 2009
  ident: 2025041509001196000_74.4.652.58
  article-title: IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0004719
– volume: 8
  year: 2013
  ident: 2025041509001196000_74.4.652.16
  article-title: The TNF-family cytokine TL1A inhibits proliferation of human activated B cells
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0060136
– ident: 2025041509001196000_74.4.652.10
  doi: 10.4049/jimmunol.1502466
– ident: 2025041509001196000_74.4.652.114
  doi: 10.1093/ibd/izy305
– ident: 2025041509001196000_74.4.652.24
  doi: 10.1073/pnas.1404178111
– ident: 2025041509001196000_74.4.652.1
  doi: 10.1016/j.cgh.2021.06.011
– ident: 2025041509001196000_74.4.652.4
  doi: 10.1038/384372a0
– volume: 13
  year: 2017
  ident: 2025041509001196000_74.4.652.88
  article-title: T cell expression of IL-18R and DR3 is essential for non-cognate stimulation of Th1 cells and optimal clearance of intracellular bacteria
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1006566
– ident: 2025041509001196000_74.4.652.119
  doi: 10.1002/art.22494
– ident: 2025041509001196000_74.4.652.33
  doi: 10.1038/mi.2012.124
– ident: 2025041509001196000_74.4.652.3
  doi: 10.1016/S1074-7613(02)00283-2
– ident: 2025041509001196000_74.4.652.122
  doi: 10.1002/cyto.b.21372
– ident: 2025041509001196000_74.4.652.126
  doi: 10.1016/j.clim.2013.03.002
– ident: 2025041509001196000_74.4.652.79
  doi: 10.1002/ibd.21638
– ident: 2025041509001196000_74.4.652.115
  doi: 10.1158/0008-5472.CAN-05-4605
– ident: 2025041509001196000_74.4.652.55
  doi: 10.1002/jgh3.12398
– ident: 2025041509001196000_74.4.652.66
  doi: 10.1096/fj.10-166843
– ident: 2025041509001196000_74.4.652.85
  doi: 10.1002/eji.200839087
– ident: 2025041509001196000_74.4.652.71
  doi: 10.1172/JCI200419836
– ident: 2025041509001196000_74.4.652.120
  doi: 10.1002/eji.200535477
– ident: 2025041509001196000_74.4.652.60
  doi: 10.1016/j.jcmgh.2020.08.003
– volume: 12
  year: 2021
  ident: 2025041509001196000_74.4.652.109
  article-title: Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Rα in Muco-Secretory Fibrotic Disorders
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2021.692127
– volume: 18
  year: 2024
  ident: 2025041509001196000_74.4.652.113
  article-title: P998 Phase 2 basket design study evaluating the efficacy and safety of an anti-TL1A antibody (TEV-48574) in moderate to severe ulcerative colitis or Crohn’s Disease (RELIEVE UCCD)
  publication-title: J Crohn's Colitis
  doi: 10.1093/ecco-jcc/jjad212.1128
– ident: 2025041509001196000_74.4.652.73
  doi: 10.1101/2024.02.09.579684
– volume: 9
  year: 2018
  ident: 2025041509001196000_74.4.652.78
  article-title: Death Receptor 3 Signaling Controls the Balance between Regulatory and Effector Lymphocytes in SAMP1/YitFc Mice with Crohn’s Disease-Like Ileitis
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2018.00362
– ident: 2025041509001196000_74.4.652.27
  doi: 10.21873/cdp.10124
– ident: 2025041509001196000_74.4.652.67
  doi: 10.1189/jlb.3A0316-129R
– ident: 2025041509001196000_74.4.652.42
  doi: 10.1038/ng.3359
– ident: 2025041509001196000_74.4.652.74
  doi: 10.1136/gutjnl-2013-305947
– ident: 2025041509001196000_74.4.652.45
  doi: 10.1093/hmg/ddac269
– volume: 48
  year: 2020
  ident: 2025041509001196000_74.4.652.83
  article-title: Tumor necrosis factor ligand-related molecule 1A affects the intestinal mucosal barrier function by promoting Th9/interleukin-9 expression
  publication-title: J Int Med Res
  doi: 10.1177/0300060520926011
– ident: 2025041509001196000_74.4.652.47
  doi: 10.1097/DCR.0000000000000274
– ident: 2025041509001196000_74.4.652.41
  doi: 10.1111/ped.12686
– ident: 2025041509001196000_74.4.652.53
  doi: 10.1016/j.crohns.2014.04.002
– ident: 2025041509001196000_74.4.652.100
  doi: 10.1093/ibd/izab193
– volume: 10
  year: 2019
  ident: 2025041509001196000_74.4.652.50
  article-title: TL1A (TNFSF15) and DR3 (TNFRSF25): A Co-stimulatory System of Cytokines With Diverse Functions in Gut Mucosal Immunity
  publication-title: Front Immunol
  doi: 10.3389/fimmu.2019.00583
– ident: 2025041509001196000_74.4.652.44
  doi: 10.1136/gutjnl-2014-308617
– volume: 15
  start-page: 258
  year: 2020
  ident: 2025041509001196000_74.4.652.29
  article-title: Gut microbial transcytosis induced by tumor necrosis factor-like 1A-dependent activation of a myosin light chain kinase splice variant contributes to IBD
  publication-title: J Crohns Colitis
  doi: 10.1093/ecco-jcc/jjaa165
– ident: 2025041509001196000_74.4.652.82
  doi: 10.1007/s10620-019-05580-z
– ident: 2025041509001196000_74.4.652.32
  doi: 10.4049/jimmunol.174.8.4985
– ident: 2025041509001196000_74.4.652.21
  doi: 10.1074/jbc.M305833200
– ident: 2025041509001196000_74.4.652.25
  doi: 10.1016/j.bcp.2011.01.011
– volume: 6
  year: 2011
  ident: 2025041509001196000_74.4.652.81
  article-title: Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0016090
– ident: 2025041509001196000_74.4.652.101
  doi: 10.1556/EuJMI.3.2013.1.2
– ident: 2025041509001196000_74.4.652.17
  doi: 10.4049/jimmunol.1301475
– volume: 6
  year: 2011
  ident: 2025041509001196000_74.4.652.48
  article-title: Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0022688
– ident: 2025041509001196000_74.4.652.11
  doi: 10.1016/S0378-1119(97)00509-X
– ident: 2025041509001196000_74.4.652.51
  doi: 10.1136/gut.2011.241877
– ident: 2025041509001196000_74.4.652.19
  doi: 10.1016/j.bone.2003.07.006
– volume: 14
  year: 2018
  ident: 2025041509001196000_74.4.652.63
  article-title: Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1007458
– ident: 2025041509001196000_74.4.652.7
  doi: 10.1073/pnas.0510903103
– ident: 2025041509001196000_74.4.652.123
  doi: 10.1016/j.clim.2008.07.014
– volume: 2
  start-page: 550
  year: 2003
  ident: 2025041509001196000_74.4.652.23
  article-title: Death receptor activation complexes: it takes two to activate TNF receptor 1
  publication-title: Cell Cycle
  doi: 10.4161/cc.2.6.566
– volume: 15
  year: 2024
  ident: 2025041509001196000_74.4.652.107
  article-title: Fibrostricturing Crohn’s Disease Is Marked by an Increase in Active Eosinophils in the Deeper Layers
  publication-title: Clin Transl Gastroenterol
  doi: 10.14309/ctg.0000000000000706
– ident: 2025041509001196000_74.4.652.75
  doi: 10.1002/1873-3468.12632
– ident: 2025041509001196000_74.4.652.31
  doi: 10.1016/j.immuni.2018.10.014
– volume: 120
  year: 2023
  ident: 2025041509001196000_74.4.652.68
  article-title: Tumor necrosis factor-like cytokine 1A plays a role in inflammatory bowel disease pathogenesis
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2120771120
– volume: 21
  start-page: 2429
  year: 2015
  ident: 2025041509001196000_74.4.652.108
  article-title: Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn’s Ileitis
  publication-title: Inflamm Bowel Dis
– ident: 2025041509001196000_74.4.652.6
  doi: 10.4049/jimmunol.171.9.4868
– volume: 221
  year: 2024
  ident: 2025041509001196000_74.4.652.94
  article-title: TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation
  publication-title: J Exp Med
  doi: 10.1084/jem.20231236
– volume: 164
  start-page: S
  year: 2023
  ident: 2025041509001196000_74.4.652.2
  article-title: 477a a phase 2, randomized, double-blind, placebo-controlled trial of PRA023 as induction therapy in patients with moderately to severely active ulcerative colitis: artemisuc, cohort 1
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(23)04753-4
– ident: 2025041509001196000_74.4.652.93
  doi: 10.1038/mi.2013.92
– ident: 2025041509001196000_74.4.652.111
  doi: 10.1111/bcp.14187
– ident: 2025041509001196000_74.4.652.39
  doi: 10.1038/ajg.2008.36
– ident: 2025041509001196000_74.4.652.76
  doi: 10.4049/jimmunol.1201908
– ident: 2025041509001196000_74.4.652.102
  doi: 10.1016/j.ajpath.2011.10.026
– ident: 2025041509001196000_74.4.652.110
  doi: 10.1111/apt.14853
– ident: 2025041509001196000_74.4.652.40
  doi: 10.1097/MIB.0000000000000584
– ident: 2025041509001196000_74.4.652.121
  doi: 10.1136/gut.2008.148908
– ident: 2025041509001196000_74.4.652.80
  doi: 10.1038/mi.2010.67
– ident: 2025041509001196000_74.4.652.86
  doi: 10.1002/eji.201041950
– ident: 2025041509001196000_74.4.652.46
  doi: 10.1159/000475439
– ident: 2025041509001196000_74.4.652.77
  doi: 10.1097/MIB.0000000000000653
– ident: 2025041509001196000_74.4.652.91
  doi: 10.1080/19490976.2019.1638725
– ident: 2025041509001196000_74.4.652.13
  doi: 10.1126/science.274.5289.990
– ident: 2025041509001196000_74.4.652.26
  doi: 10.1074/jbc.274.20.13733
– ident: 2025041509001196000_74.4.652.112
  doi: 10.1093/ecco-jcc/jjac190.0127
– ident: 2025041509001196000_74.4.652.59
  doi: 10.1093/hmg/ddp005
– ident: 2025041509001196000_74.4.652.34
  doi: 10.4049/jimmunol.172.11.7002
– ident: 2025041509001196000_74.4.652.43
  doi: 10.1038/S41588-023-01384-0
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Snippet TNF-like cytokine 1A (TL1A) and its functional receptor, death-domain receptor 3 (DR3), are members of the TNF and TNFR superfamilies, respectively, with...
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SubjectTerms Amino acids
Animals
CROHN'S DISEASE
CYTOKINES
Gene polymorphism
Humans
Immune response
Immunology
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - drug therapy
Inflammatory Bowel Diseases - immunology
Intestine
Kinases
Ligands
Lymphoid cells
Monoclonal antibodies
Pathogenesis
Proteins
Recent advances in basic science
Receptors, Tumor Necrosis Factor, Member 25 - antagonists & inhibitors
Receptors, Tumor Necrosis Factor, Member 25 - immunology
Receptors, Tumor Necrosis Factor, Member 25 - metabolism
Receptors, Tumor Necrosis Factor, Member 25 - physiology
Signal Transduction
Stromal cells
Tumor Necrosis Factor Ligand Superfamily Member 15 - antagonists & inhibitors
Tumor Necrosis Factor Ligand Superfamily Member 15 - immunology
Tumor Necrosis Factor Ligand Superfamily Member 15 - metabolism
Tumor Necrosis Factor Ligand Superfamily Member 15 - physiology
Tumor necrosis factor receptors
Tumor necrosis factor-TNF
ULCERATIVE COLITIS
Title Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD
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