Urinary excretion of platinum from South African precious metals refinery workers

BackgroundUrinary platinum (Pt) excretion is a reliable biomarker for occupational Pt exposure and has been previously reported for precious metals refinery workers in Europe but not for South Africa, the world’s largest producer of Pt.ObjectiveThis study aimed to quantify the urinary Pt excretion o...

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Vydáno v:Occupational and environmental medicine (London, England) Ročník 75; číslo 6; s. 436 - 442
Hlavní autoři: Linde, Stephanus J L, Franken, Anja, du Plessis, Johannes L
Médium: Journal Article
Jazyk:angličtina
Vydáno: England BMJ 01.06.2018
BMJ Publishing Group LTD
Témata:
Automotive bodies
Automotive engineering
Biomarkers
Blue collar workers
Body burden
Creatinine
Excretion
Exposure
Heavy metals
Inductively coupled plasma mass spectrometry
Mass spectrometry
Mass spectroscopy
Medical research
Metals
Noble metals
Occupational exposure
ORIGINAL ARTICLE
Platinum
Refineries
Skin
Studies
Urine
South Africa
Europe
body burden
exposure assessment
biomonitoring
platinum group metals
ISSN:1351-0711, 1470-7926, 1470-7926
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Shrnutí:BackgroundUrinary platinum (Pt) excretion is a reliable biomarker for occupational Pt exposure and has been previously reported for precious metals refinery workers in Europe but not for South Africa, the world’s largest producer of Pt.ObjectiveThis study aimed to quantify the urinary Pt excretion of South African precious metals refinery workers.MethodsSpot urine samples were collected from 40 workers (directly and indirectly exposed to Pt) at two South African precious metals refineries on three consecutive mornings prior to their shifts. Urine samples were analysed for Pt using inductively coupled plasma-mass spectrometry and were corrected for creatinine content.ResultsThe urinary Pt excretion of workers did not differ significantly between sampling days. Urinary Pt excretions ranged from <0.1 to 3.0 µg Pt/g creatinine with a geometric mean of 0.21 µg Pt/g creatinine (95% CI 0.17 to 0.26 µg Pt/g creatinine). The work area (P=0.0006; η2=0.567) and the number of years workers were employed at the refineries (P=0.003; η2=0.261) influenced their urinary Pt excretion according to effect size analyses. Directly exposed workers had significantly higher urinary Pt excretion compared with indirectly exposed workers (P=0.007).ConclusionThe urinary Pt excretion of South African precious metals refinery workers reported in this study is comparable with that of seven other studies conducted in precious metals refineries and automotive catalyst plants in Europe. The Pt body burden of workers is predominantly determined by their work area, years of employment in the refineries and whether they are directly or indirectly exposed to Pt.
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ISSN:1351-0711
1470-7926
1470-7926
DOI:10.1136/oemed-2017-104820