Retinal segmented layers with strong aquaporin-4 expression suffered more injuries in neuromyelitis optica spectrum disorders compared with optic neuritis with aquaporin-4 antibody seronegativity detected by optical coherence tomography

PurposeTo evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with ON eyes (NMO-ON) compared with an AQP4-Ab seronegative ON (AQP4-Ab−/ON) cohort using optical coherence tomography (OCT).MethodsWe recru...

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Veröffentlicht in:	British journal of ophthalmology Jg. 101; H. 8; S. 1032 - 1037
Hauptverfasser:	Peng, Chun xia, Li, Hong Yang, Wang, Wei, Wang, Jun qing, Wang, Lei, Xu, Quan gang, Cao, Shan shan, Zhou, Huan fen, Zhao, Shuo, Wei, Shi hui
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England BMJ Publishing Group LTD 01.08.2017
Schlagworte:	Adolescent Adult Aged Aquaporin 4 - immunology Aquaporin 4 - metabolism Aquaporins Autoantibodies - blood Automation Biomarkers Case-Control Studies Edema Ethnicity Female Humans Injuries Male Medical diagnosis Medical research Middle Aged Multiple sclerosis Nerve Fibers Neuromyelitis Optica - diagnostic imaging Neuromyelitis Optica - etiology Neuromyelitis Optica - pathology Ophthalmology Optic nerve Optic Neuritis - diagnostic imaging Optic Neuritis - etiology Optic Neuritis - pathology Optics Pathogenesis Retina Retina - diagnostic imaging Retina - metabolism Retinal Diseases - diagnostic imaging Retinal Diseases - etiology Retinal Diseases - pathology Tomography, Optical Coherence Young Adult Pathology Retina Imaging Optic Nerve Diagnostic tests/Investigation
ISSN:	0007-1161, 1468-2079
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Abstract	PurposeTo evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with ON eyes (NMO-ON) compared with an AQP4-Ab seronegative ON (AQP4-Ab−/ON) cohort using optical coherence tomography (OCT).MethodsWe recruited 109 patients with ON (161 eyes) and 47 healthy controls. All patients with ON were subdivided into three subcohorts: 37 patients (54 eyes) with AQP4-Ab+/ON, 45 patients (65 eyes) with AQP4-Ab−/ON and 27 patients (42 eyes) with NMO-ON. All subjects were evaluated for their peripapillary retinal nerve fibre layer (pRNFL) and inner macular segmented layer using OCT.ResultsAQP4-Ab+/patients with ON had the same structural injury patterns as patients with NMO-ON, and the injury patterns were distinct from those of AQP4-Ab−/patients with ON. NMO-ON and AQP4-Ab+/ON preferentially damaged the pRNFL (all p=0.000), the macular retinal nerve fibre layer (mRNFL; p=0.000 and 0.032, respectively), and the inner plexiform layer (IPL; p=0.000 and 0.006, respectively) without differences in the retinal ganglion cell layer (p=0.106 and 0.374, respectively) compared with AQP4-Ab−/patients with ON. The thickness of the inner nuclear layer (INL) increased in NMO-ON (p=0.043) compared with that of AQP4-Ab−/ON without a significant difference in AQP4-Ab+/ON versus AQP4-Ab−/ON (p=0.353). When the thickness of the inferior nasal quadrant (NI) of the pRNFL was reduced to ≤46.5 μm (area under the curve 0.772, sensitivity 89.2% and specificity 57.5%) 6 months after ON onset, NMO was considered.ConclusionsAQP4-Ab+/ON produced similar structural injury patterns as NMO-ON. The pRNFL, mRNFL and IPL in the two types of ON and the INL in NMO-ON suffered more damage than those in AQP4-Ab−/ON, which could be associated with strong aquaporin-4 expression. The thickness of the NI of the pRNFL could be a potential clue for predicting ON progression to definite NMO.
AbstractList	PURPOSETo evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with ON eyes (NMO-ON) compared with an AQP4-Ab seronegative ON (AQP4-Ab-/ON) cohort using optical coherence tomography (OCT).METHODSWe recruited 109 patients with ON (161 eyes) and 47 healthy controls. All patients with ON were subdivided into three subcohorts: 37 patients (54 eyes) with AQP4-Ab+/ON, 45 patients (65 eyes) with AQP4-Ab-/ON and 27 patients (42 eyes) with NMO-ON. All subjects were evaluated for their peripapillary retinal nerve fibre layer (pRNFL) and inner macular segmented layer using OCT.RESULTSAQP4-Ab+/patients with ON had the same structural injury patterns as patients with NMO-ON, and the injury patterns were distinct from those of AQP4-Ab-/patients with ON. NMO-ON and AQP4-Ab+/ON preferentially damaged the pRNFL (all p=0.000), the macular retinal nerve fibre layer (mRNFL; p=0.000 and 0.032, respectively), and the inner plexiform layer (IPL; p=0.000 and 0.006, respectively) without differences in the retinal ganglion cell layer (p=0.106 and 0.374, respectively) compared with AQP4-Ab-/patients with ON. The thickness of the inner nuclear layer (INL) increased in NMO-ON (p=0.043) compared with that of AQP4-Ab-/ON without a significant difference in AQP4-Ab+/ON versus AQP4-Ab-/ON (p=0.353). When the thickness of the inferior nasal quadrant (NI) of the pRNFL was reduced to ≤46.5 μm (area under the curve 0.772, sensitivity 89.2% and specificity 57.5%) 6 months after ON onset, NMO was considered.CONCLUSIONSAQP4-Ab+/ON produced similar structural injury patterns as NMO-ON. The pRNFL, mRNFL and IPL in the two types of ON and the INL in NMO-ON suffered more damage than those in AQP4-Ab-/ON, which could be associated with strong aquaporin-4 expression. The thickness of the NI of the pRNFL could be a potential clue for predicting ON progression to definite NMO. PurposeTo evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with ON eyes (NMO-ON) compared with an AQP4-Ab seronegative ON (AQP4-Ab−/ON) cohort using optical coherence tomography (OCT).MethodsWe recruited 109 patients with ON (161 eyes) and 47 healthy controls. All patients with ON were subdivided into three subcohorts: 37 patients (54 eyes) with AQP4-Ab+/ON, 45 patients (65 eyes) with AQP4-Ab−/ON and 27 patients (42 eyes) with NMO-ON. All subjects were evaluated for their peripapillary retinal nerve fibre layer (pRNFL) and inner macular segmented layer using OCT.ResultsAQP4-Ab+/patients with ON had the same structural injury patterns as patients with NMO-ON, and the injury patterns were distinct from those of AQP4-Ab−/patients with ON. NMO-ON and AQP4-Ab+/ON preferentially damaged the pRNFL (all p=0.000), the macular retinal nerve fibre layer (mRNFL; p=0.000 and 0.032, respectively), and the inner plexiform layer (IPL; p=0.000 and 0.006, respectively) without differences in the retinal ganglion cell layer (p=0.106 and 0.374, respectively) compared with AQP4-Ab−/patients with ON. The thickness of the inner nuclear layer (INL) increased in NMO-ON (p=0.043) compared with that of AQP4-Ab−/ON without a significant difference in AQP4-Ab+/ON versus AQP4-Ab−/ON (p=0.353). When the thickness of the inferior nasal quadrant (NI) of the pRNFL was reduced to ≤46.5 μm (area under the curve 0.772, sensitivity 89.2% and specificity 57.5%) 6 months after ON onset, NMO was considered.ConclusionsAQP4-Ab+/ON produced similar structural injury patterns as NMO-ON. The pRNFL, mRNFL and IPL in the two types of ON and the INL in NMO-ON suffered more damage than those in AQP4-Ab−/ON, which could be associated with strong aquaporin-4 expression. The thickness of the NI of the pRNFL could be a potential clue for predicting ON progression to definite NMO. To evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with ON eyes (NMO-ON) compared with an AQP4-Ab seronegative ON (AQP4-Ab-/ON) cohort using optical coherence tomography (OCT). We recruited 109 patients with ON (161 eyes) and 47 healthy controls. All patients with ON were subdivided into three subcohorts: 37 patients (54 eyes) with AQP4-Ab+/ON, 45 patients (65 eyes) with AQP4-Ab-/ON and 27 patients (42 eyes) with NMO-ON. All subjects were evaluated for their peripapillary retinal nerve fibre layer (pRNFL) and inner macular segmented layer using OCT. AQP4-Ab+/patients with ON had the same structural injury patterns as patients with NMO-ON, and the injury patterns were distinct from those of AQP4-Ab-/patients with ON. NMO-ON and AQP4-Ab+/ON preferentially damaged the pRNFL (all p=0.000), the macular retinal nerve fibre layer (mRNFL; p=0.000 and 0.032, respectively), and the inner plexiform layer (IPL; p=0.000 and 0.006, respectively) without differences in the retinal ganglion cell layer (p=0.106 and 0.374, respectively) compared with AQP4-Ab-/patients with ON. The thickness of the inner nuclear layer (INL) increased in NMO-ON (p=0.043) compared with that of AQP4-Ab-/ON without a significant difference in AQP4-Ab+/ON versus AQP4-Ab-/ON (p=0.353). When the thickness of the inferior nasal quadrant (NI) of the pRNFL was reduced to ≤46.5 μm (area under the curve 0.772, sensitivity 89.2% and specificity 57.5%) 6 months after ON onset, NMO was considered. AQP4-Ab+/ON produced similar structural injury patterns as NMO-ON. The pRNFL, mRNFL and IPL in the two types of ON and the INL in NMO-ON suffered more damage than those in AQP4-Ab-/ON, which could be associated with strong aquaporin-4 expression. The thickness of the NI of the pRNFL could be a potential clue for predicting ON progression to definite NMO. Purpose To evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with ON eyes (NMO-ON) compared with an AQP4-Ab seronegative ON (AQP4-Ab-/ON) cohort using optical coherence tomography (OCT). Methods We recruited 109 patients with ON (161 eyes) and 47 healthy controls. All patients with ON were subdivided into three subcohorts: 37 patients (54 eyes) with AQP4-Ab+/ON, 45 patients (65 eyes) with AQP4-Ab-/ON and 27 patients (42 eyes) with NMO-ON. All subjects were evaluated for their peripapillary retinal nerve fibre layer (pRNFL) and inner macular segmented layer using OCT. Results AQP4-Ab+/patients with ON had the same structural injury patterns as patients with NMO-ON, and the injury patterns were distinct from those of AQP4-Ab-/patients with ON. NMO-ON and AQP4-Ab+/ON preferentially damaged the pRNFL (all p=0.000), the macular retinal nerve fibre layer (mRNFL; p=0.000 and 0.032, respectively), and the inner plexiform layer (IPL; p=0.000 and 0.006, respectively) without differences in the retinal ganglion cell layer (p=0.106 and 0.374, respectively) compared with AQP4-Ab-/patients with ON. The thickness of the inner nuclear layer (INL) increased in NMO-ON (p=0.043) compared with that of AQP4-Ab-/ON without a significant difference in AQP4-Ab+/ON versus AQP4-Ab-/ON (p=0.353). When the thickness of the inferior nasal quadrant (NI) of the pRNFL was reduced to ≤46.5 μm (area under the curve 0.772, sensitivity 89.2% and specificity 57.5%) 6 months after ON onset, NMO was considered. Conclusions AQP4-Ab+/ON produced similar structural injury patterns as NMO-ON. The pRNFL, mRNFL and IPL in the two types of ON and the INL in NMO-ON suffered more damage than those in AQP4-Ab-/ON, which could be associated with strong aquaporin-4 expression. The thickness of the NI of the pRNFL could be a potential clue for predicting ON progression to definite NMO.
Author	Cao, Shan shan Peng, Chun xia Wang, Wei Wei, Shi hui Wang, Lei Zhao, Shuo Xu, Quan gang Wang, Jun qing Li, Hong Yang Zhou, Huan fen
Author_xml	– sequence: 1 givenname: Chun xia surname: Peng fullname: Peng, Chun xia email: weishihui706@hotmail.com organization: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China – sequence: 2 givenname: Hong Yang surname: Li fullname: Li, Hong Yang email: weishihui706@hotmail.com organization: Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China – sequence: 3 givenname: Wei surname: Wang fullname: Wang, Wei email: weishihui706@hotmail.com organization: Zhongshan Ophthalmic Center, Sun yat-sen University, Guangzhou, China – sequence: 4 givenname: Jun qing surname: Wang fullname: Wang, Jun qing email: weishihui706@hotmail.com organization: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China – sequence: 5 givenname: Lei surname: Wang fullname: Wang, Lei email: weishihui706@hotmail.com organization: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China – sequence: 6 givenname: Quan gang surname: Xu fullname: Xu, Quan gang email: weishihui706@hotmail.com organization: Neurology Department, Chinese PLA General Hospital, Beijing, China – sequence: 7 givenname: Shan shan surname: Cao fullname: Cao, Shan shan email: weishihui706@hotmail.com organization: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China – sequence: 8 givenname: Huan fen surname: Zhou fullname: Zhou, Huan fen email: weishihui706@hotmail.com organization: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China – sequence: 9 givenname: Shuo surname: Zhao fullname: Zhao, Shuo email: weishihui706@hotmail.com organization: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China – sequence: 10 givenname: Shi hui surname: Wei fullname: Wei, Shi hui email: weishihui706@hotmail.com organization: Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China
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Keywords	Pathology Retina Imaging Optic Nerve Diagnostic tests/Investigation
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sclerosis: a systematic review and meta-analysis publication-title: Lancet Neurol doi: 10.1016/S1474-4422(10)70168-X
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Snippet	PurposeTo evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO)... To evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO) with... Purpose To evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica... PURPOSETo evaluate retinal segmented layer alterations in optic neuritis (ON) in an AQP4-Ab seropositive (AQP4-Ab+/ON) cohort and in neuromyelitis optica (NMO)...
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SubjectTerms	Adolescent Adult Aged Aquaporin 4 - immunology Aquaporin 4 - metabolism Aquaporins Autoantibodies - blood Automation Biomarkers Case-Control Studies Edema Ethnicity Female Humans Injuries Male Medical diagnosis Medical research Middle Aged Multiple sclerosis Nerve Fibers Neuromyelitis Optica - diagnostic imaging Neuromyelitis Optica - etiology Neuromyelitis Optica - pathology Ophthalmology Optic nerve Optic Neuritis - diagnostic imaging Optic Neuritis - etiology Optic Neuritis - pathology Optics Pathogenesis Retina Retina - diagnostic imaging Retina - metabolism Retinal Diseases - diagnostic imaging Retinal Diseases - etiology Retinal Diseases - pathology Tomography, Optical Coherence Young Adult
Title	Retinal segmented layers with strong aquaporin-4 expression suffered more injuries in neuromyelitis optica spectrum disorders compared with optic neuritis with aquaporin-4 antibody seronegativity detected by optical coherence tomography
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