STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis

ObjectiveThe absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA sensor promotes the pathogenesis of autoimmune and chronic inflammatory diseases via caspase-1-containing inflammasome complexes. However, the role of AIM2 in cancer is ill-defined.DesignThe expression of AIM2 an...

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Vydané v:	Gut Ročník 71; číslo 8; s. 1515 - 1531
Hlavní autori:	Dawson, Ruby E, Deswaerte, Virginie, West, Alison C, Tang, Ke, West, Alice J, Balic, Jesse J, Gearing, Linden J, Saad, Mohamed I, Yu, Liang, Wu, Yonghui, Bhathal, Prithi S, Kumar, Beena, Chakrabarti, Jayati T, Zavros, Yana, Oshima, Hiroko, Klinman, Dennis M, Oshima, Masanobu, Tan, Patrick, Jenkins, Brendan J
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.08.2022 BMJ Publishing Group LTD
Predmet:	Animal models Apoptosis Biopsy Carcinogenesis Caspase-1 Cell adhesion & migration Cell migration Cytokines Deoxyribonucleic acid DNA Epithelial cells Epithelium Gastric cancer Gene expression Genetic engineering immunology Inflammasomes Inflammation Inflammatory diseases Innate immunity Interleukin 11 Medical research Melanoma molecular biology Pathogenesis Patients Pattern recognition Pattern recognition receptors Protein expression Proteins Sensors Stat3 protein Stomach Survival analysis Therapeutic targets Tumorigenesis Tumors Xenografts Singapore
ISSN:	0017-5749, 1468-3288, 1468-3288
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Abstract	ObjectiveThe absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA sensor promotes the pathogenesis of autoimmune and chronic inflammatory diseases via caspase-1-containing inflammasome complexes. However, the role of AIM2 in cancer is ill-defined.DesignThe expression of AIM2 and its clinical significance was assessed in human gastric cancer (GC) patient cohorts. Genetic or therapeutic manipulation of AIM2 expression and activity was performed in the genetically engineered gp130 F/F spontaneous GC mouse model, as well as human GC cell line xenografts. The biological role and mechanism of action of AIM2 in gastric tumourigenesis, including its involvement in inflammasome activity and functional interaction with microtubule-associated end-binding protein 1 (EB1), was determined in vitro and in vivo.ResultsAIM2 expression is upregulated by interleukin-11 cytokine-mediated activation of the oncogenic latent transcription factor STAT3 in the tumour epithelium of GC mouse models and patients with GC. Genetic and therapeutic targeting of AIM2 in gp130 F/F mice suppressed tumourigenesis. Conversely, AIM2 overexpression augmented the tumour load of human GC cell line xenografts. The protumourigenic function of AIM2 was independent of inflammasome activity and inflammation. Rather, in vivo and in vitro AIM2 physically interacted with EB1 to promote epithelial cell migration and tumourigenesis. Furthermore, upregulated expression of AIM2 and EB1 in the tumour epithelium of patients with GC was independently associated with poor patient survival.ConclusionAIM2 can play a driver role in epithelial carcinogenesis by linking cytokine-STAT3 signalling, innate immunity and epithelial cell migration, independent of inflammasome activation.
AbstractList	ObjectiveThe absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA sensor promotes the pathogenesis of autoimmune and chronic inflammatory diseases via caspase-1-containing inflammasome complexes. However, the role of AIM2 in cancer is ill-defined.DesignThe expression of AIM2 and its clinical significance was assessed in human gastric cancer (GC) patient cohorts. Genetic or therapeutic manipulation of AIM2 expression and activity was performed in the genetically engineered gp130F/F spontaneous GC mouse model, as well as human GC cell line xenografts. The biological role and mechanism of action of AIM2 in gastric tumourigenesis, including its involvement in inflammasome activity and functional interaction with microtubule-associated end-binding protein 1 (EB1), was determined in vitro and in vivo.ResultsAIM2 expression is upregulated by interleukin-11 cytokine-mediated activation of the oncogenic latent transcription factor STAT3 in the tumour epithelium of GC mouse models and patients with GC. Genetic and therapeutic targeting of AIM2 in gp130F/F mice suppressed tumourigenesis. Conversely, AIM2 overexpression augmented the tumour load of human GC cell line xenografts. The protumourigenic function of AIM2 was independent of inflammasome activity and inflammation. Rather, in vivo and in vitro AIM2 physically interacted with EB1 to promote epithelial cell migration and tumourigenesis. Furthermore, upregulated expression of AIM2 and EB1 in the tumour epithelium of patients with GC was independently associated with poor patient survival.ConclusionAIM2 can play a driver role in epithelial carcinogenesis by linking cytokine-STAT3 signalling, innate immunity and epithelial cell migration, independent of inflammasome activation. The absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA sensor promotes the pathogenesis of autoimmune and chronic inflammatory diseases via caspase-1-containing inflammasome complexes. However, the role of AIM2 in cancer is ill-defined.OBJECTIVEThe absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA sensor promotes the pathogenesis of autoimmune and chronic inflammatory diseases via caspase-1-containing inflammasome complexes. However, the role of AIM2 in cancer is ill-defined.The expression of AIM2 and its clinical significance was assessed in human gastric cancer (GC) patient cohorts. Genetic or therapeutic manipulation of AIM2 expression and activity was performed in the genetically engineered gp130 F/F spontaneous GC mouse model, as well as human GC cell line xenografts. The biological role and mechanism of action of AIM2 in gastric tumourigenesis, including its involvement in inflammasome activity and functional interaction with microtubule-associated end-binding protein 1 (EB1), was determined in vitro and in vivo.DESIGNThe expression of AIM2 and its clinical significance was assessed in human gastric cancer (GC) patient cohorts. Genetic or therapeutic manipulation of AIM2 expression and activity was performed in the genetically engineered gp130 F/F spontaneous GC mouse model, as well as human GC cell line xenografts. The biological role and mechanism of action of AIM2 in gastric tumourigenesis, including its involvement in inflammasome activity and functional interaction with microtubule-associated end-binding protein 1 (EB1), was determined in vitro and in vivo.AIM2 expression is upregulated by interleukin-11 cytokine-mediated activation of the oncogenic latent transcription factor STAT3 in the tumour epithelium of GC mouse models and patients with GC. Genetic and therapeutic targeting of AIM2 in gp130 F/F mice suppressed tumourigenesis. Conversely, AIM2 overexpression augmented the tumour load of human GC cell line xenografts. The protumourigenic function of AIM2 was independent of inflammasome activity and inflammation. Rather, in vivo and in vitro AIM2 physically interacted with EB1 to promote epithelial cell migration and tumourigenesis. Furthermore, upregulated expression of AIM2 and EB1 in the tumour epithelium of patients with GC was independently associated with poor patient survival.RESULTSAIM2 expression is upregulated by interleukin-11 cytokine-mediated activation of the oncogenic latent transcription factor STAT3 in the tumour epithelium of GC mouse models and patients with GC. Genetic and therapeutic targeting of AIM2 in gp130 F/F mice suppressed tumourigenesis. Conversely, AIM2 overexpression augmented the tumour load of human GC cell line xenografts. The protumourigenic function of AIM2 was independent of inflammasome activity and inflammation. Rather, in vivo and in vitro AIM2 physically interacted with EB1 to promote epithelial cell migration and tumourigenesis. Furthermore, upregulated expression of AIM2 and EB1 in the tumour epithelium of patients with GC was independently associated with poor patient survival.AIM2 can play a driver role in epithelial carcinogenesis by linking cytokine-STAT3 signalling, innate immunity and epithelial cell migration, independent of inflammasome activation.CONCLUSIONAIM2 can play a driver role in epithelial carcinogenesis by linking cytokine-STAT3 signalling, innate immunity and epithelial cell migration, independent of inflammasome activation. ObjectiveThe absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA sensor promotes the pathogenesis of autoimmune and chronic inflammatory diseases via caspase-1-containing inflammasome complexes. However, the role of AIM2 in cancer is ill-defined.DesignThe expression of AIM2 and its clinical significance was assessed in human gastric cancer (GC) patient cohorts. Genetic or therapeutic manipulation of AIM2 expression and activity was performed in the genetically engineered gp130 F/F spontaneous GC mouse model, as well as human GC cell line xenografts. The biological role and mechanism of action of AIM2 in gastric tumourigenesis, including its involvement in inflammasome activity and functional interaction with microtubule-associated end-binding protein 1 (EB1), was determined in vitro and in vivo.ResultsAIM2 expression is upregulated by interleukin-11 cytokine-mediated activation of the oncogenic latent transcription factor STAT3 in the tumour epithelium of GC mouse models and patients with GC. Genetic and therapeutic targeting of AIM2 in gp130 F/F mice suppressed tumourigenesis. Conversely, AIM2 overexpression augmented the tumour load of human GC cell line xenografts. The protumourigenic function of AIM2 was independent of inflammasome activity and inflammation. Rather, in vivo and in vitro AIM2 physically interacted with EB1 to promote epithelial cell migration and tumourigenesis. Furthermore, upregulated expression of AIM2 and EB1 in the tumour epithelium of patients with GC was independently associated with poor patient survival.ConclusionAIM2 can play a driver role in epithelial carcinogenesis by linking cytokine-STAT3 signalling, innate immunity and epithelial cell migration, independent of inflammasome activation.
Author	Tang, Ke Oshima, Masanobu Oshima, Hiroko Kumar, Beena West, Alice J Bhathal, Prithi S Chakrabarti, Jayati T Balic, Jesse J Gearing, Linden J Yu, Liang Dawson, Ruby E Tan, Patrick West, Alison C Zavros, Yana Saad, Mohamed I Jenkins, Brendan J Deswaerte, Virginie Wu, Yonghui Klinman, Dennis M
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Cites_doi	10.1016/j.ccr.2012.08.010 10.1038/s41388-020-1176-9 10.1007/978-1-4939-8600-2_15 10.18632/oncotarget.9154 10.3390/ijms15069594 10.1074/jbc.M114.559153 10.1038/onc.2017.121 10.1016/j.ceb.2015.06.007 10.1038/icb.2013.58 10.1210/en.2014-1720 10.1016/j.cell.2010.01.022 10.1038/nm.3908 10.3389/fimmu.2014.00336 10.3322/caac.21492 10.1016/j.cell.2015.06.001 10.1158/0008-5472.CAN-19-0974 10.1038/sj.onc.1210904 10.1038/cmi.2016.35 10.1016/j.molimm.2016.09.023 10.1172/JCI34944 10.1038/nm1282 10.1242/jcs.207365 10.1016/j.canlet.2009.04.007 10.1038/nm.3850 10.1038/nri3446 10.1038/sj.onc.1201206 10.1158/0008-5472.CAN-17-1887 10.1172/jci.insight.94035 10.1158/1078-0432.CCR-17-2485 10.1016/j.immuni.2019.06.025 10.1038/ncb1762 10.1016/j.ccr.2008.10.011 10.4049/jimmunol.1300530 10.1053/j.gastro.2006.07.014 10.1016/j.bbamcr.2015.10.022 10.1007/7651_2016_4 10.3389/fimmu.2014.00327 10.1002/jcp.28617 10.2174/1381612821666150514104411 10.1172/JCI30111 10.1007/s10585-008-9174-2 10.1096/fj.201700444RR 10.1186/1471-2164-10-615 10.1038/s41598-019-39636-x 10.1002/eji.201848070 10.1074/mcp.M112.020594 10.1371/journal.pone.0131702 10.1016/j.phrs.2016.03.038 10.1007/978-3-030-15138-6_5 10.1038/s41568-019-0123-y 10.1371/journal.pgen.1000676 10.1158/1538-7445.SABCS18-5272 10.1002/jcp.25124
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References	Malik, Kanneganti (R8) 2017; 130 Man, Zhu, Zhu (R17) 2015; 162 Sokolova, Naumann (R25) 2019; 421 Micera, Balzamino, Di Zazzo (R13) 2016; 23 Tu, Bhagat, Cui (R5) 2008; 14 Bertaux-Skeirik, Centeno, Gao (R54) 2019; 1576 O'Neill, Golenbock, Bowie (R7) 2013; 13 Ratsimandresy, Indramohan, Dorfleutner (R34) 2017; 14 Qi, Dai, Liu (R46) 2020; 39 Bray, Ferlay, Soerjomataram (R3) 2018; 68 Cristescu, Lee, Nebozhyn (R24) 2015; 21 Kaminski, Schattgen, Tzeng (R33) 2013; 191 Jacquemet, Hamidi, Ivaska (R37) 2015; 36 Takeuchi, Akira (R9) 2010; 140 Olson, Sahai (R38) 2009; 26 Zhang, Jin, Yang (R47) 2019; 234 Simpson, Selfors, Bui (R36) 2008; 10 Huang, Zhao, Unkeless (R49) 2008; 27 Ernst, Najdovska, Grail (R28) 2008; 118 Jenkins, Grail, Nheu (R30) 2005; 11 Gallaher, Brown, Anderson (R44) 2019; 9 Balic, Garama, Saad (R31) 2019; 79 Sharma, Karki, Kanneganti (R11) 2019; 49 Jayatilaka, Giri, Karl (R41) 2018; 32 Schober, Cain, Komarova (R40) 2009; 284 Bronkhorst, Wentzel, Aucamp (R35) 2016; 1863 Yakata, Nakayama, Yoshizaki (R50) 2007; 30 Oshima, Matsunaga, Fujimura (R51) 2006; 131 Saxena, Yeretssian (R10) 2014; 5 Wang, Huang, Huang (R43) 2014; 289 Deswaerte, Nguyen, West (R6) 2018; 78 Greten, Grivennikov, Inflammation (R2) 2019; 51 Tye, Kennedy, Najdovska (R4) 2012; 22 Wang, Hsu, Chen (R42) 2012; 11 Itadani, Oshima, Oshima (R32) 2009; 10 Escamilla-Tilch, Filio-Rodríguez, García-Rocha (R12) 2013; 91 Fox, Wang (R1) 2007; 117 Parlato, Yeretssian (R15) 2014; 15 Salvador, Arranz, Francisco (R14) 2016; 108 West, Jenkins (R16) 2015; 21 Ooi, Ivanova, Wu (R23) 2009; 5 Karki, Kanneganti (R22) 2019; 19 West, Tang, Tye (R21) 2017; 36 Teal, Bertaux-Skeirik, Chakrabarti (R53) 2018; 1817 Deswaerte, Ruwanpura, Jenkins (R19) 2017; 86 Castaño-Rodríguez, Kaakoush, Mitchell (R20) 2014; 5 El-Zaatari, Bishu, Zhang (R48) 2020; 5 Ma, Guo, Qiu (R45) 2016; 7 Kuo, Yang (R26) 2008; 22 Yu, Wu, Gao (R29) 2018; 24 DeYoung, Ray, Su (R27) 1997; 15 Tang, Mok, Lee (R39) 2015; 156 Jakobs, Perner, Hornung (R52) 2015; 10 Wilson, Petrucelli, Chen (R18) 2015; 21 Wilson, Petrucelli, Chen 2015; 21 Ooi, Ivanova, Wu 2009; 5 Man, Zhu, Zhu 2015; 162 Deswaerte, Nguyen, West 2018; 78 Micera, Balzamino, Di Zazzo 2016; 23 Saxena, Yeretssian 2014; 5 Jayatilaka, Giri, Karl 2018; 32 Jenkins, Grail, Nheu 2005; 11 Gallaher, Brown, Anderson 2019; 9 Ernst, Najdovska, Grail 2008; 118 Sokolova, Naumann 2019; 421 Yakata, Nakayama, Yoshizaki 2007; 30 Ratsimandresy, Indramohan, Dorfleutner 2017; 14 Fox, Wang 2007; 117 Bertaux-Skeirik, Centeno, Gao 2019; 1576 Parlato, Yeretssian 2014; 15 Ma, Guo, Qiu 2016; 7 Escamilla-Tilch, Filio-Rodríguez, García-Rocha 2013; 91 Kaminski, Schattgen, Tzeng 2013; 191 Itadani, Oshima, Oshima 2009; 10 West, Jenkins 2015; 21 Jakobs, Perner, Hornung 2015; 10 Kuo, Yang 2008; 22 Bray, Ferlay, Soerjomataram 2018; 68 Balic, Garama, Saad 2019; 79 Malik, Kanneganti 2017; 130 Greten, Grivennikov, Inflammation 2019; 51 Sharma, Karki, Kanneganti 2019; 49 Yu, Wu, Gao 2018; 24 Qi, Dai, Liu 2020; 39 Huang, Zhao, Unkeless 2008; 27 Takeuchi, Akira 2010; 140 Teal, Bertaux-Skeirik, Chakrabarti 2018; 1817 Salvador, Arranz, Francisco 2016; 108 DeYoung, Ray, Su 1997; 15 Wang, Huang, Huang 2014; 289 Karki, Kanneganti 2019; 19 West, Tang, Tye 2017; 36 Jacquemet, Hamidi, Ivaska 2015; 36 Wang, Hsu, Chen 2012; 11 Oshima, Matsunaga, Fujimura 2006; 131 Tu, Bhagat, Cui 2008; 14 Bronkhorst, Wentzel, Aucamp 2016; 1863 Cristescu, Lee, Nebozhyn 2015; 21 Deswaerte, Ruwanpura, Jenkins 2017; 86 Olson, Sahai 2009; 26 Castaño-Rodríguez, Kaakoush, Mitchell 2014; 5 El-Zaatari, Bishu, Zhang 2020; 5 Simpson, Selfors, Bui 2008; 10 Tang, Mok, Lee 2015; 156 Tye, Kennedy, Najdovska 2012; 22 O'Neill, Golenbock, Bowie 2013; 13 Zhang, Jin, Yang 2019; 234 Schober, Cain, Komarova 2009; 284 Gallaher (2025090800430298000_71.8.1515.44) 2019; 9 Bertaux-Skeirik (2025090800430298000_71.8.1515.54) 2019; 1576 Micera (2025090800430298000_71.8.1515.13) 2016; 23 2025090800430298000_71.8.1515.24 2025090800430298000_71.8.1515.23 2025090800430298000_71.8.1515.22 2025090800430298000_71.8.1515.17 2025090800430298000_71.8.1515.16 Bronkhorst (2025090800430298000_71.8.1515.35) 2016; 1863 2025090800430298000_71.8.1515.15 Teal (2025090800430298000_71.8.1515.53) 2018; 1817 2025090800430298000_71.8.1515.18 Yakata (2025090800430298000_71.8.1515.50) 2007; 30 West (2025090800430298000_71.8.1515.21) 2017; 36 2025090800430298000_71.8.1515.52 2025090800430298000_71.8.1515.51 2025090800430298000_71.8.1515.12 2025090800430298000_71.8.1515.11 2025090800430298000_71.8.1515.10 Jayatilaka (2025090800430298000_71.8.1515.41) 2018; 32 2025090800430298000_71.8.1515.49 Deswaerte (2025090800430298000_71.8.1515.19) 2017; 86 El-Zaatari (2025090800430298000_71.8.1515.48) 2020; 5 Castaño-Rodríguez (2025090800430298000_71.8.1515.20) 2014; 5 Ratsimandresy (2025090800430298000_71.8.1515.34) 2017; 14 2025090800430298000_71.8.1515.42 2025090800430298000_71.8.1515.40 Salvador (2025090800430298000_71.8.1515.14) 2016; 108 Qi (2025090800430298000_71.8.1515.46) 2020; 39 2025090800430298000_71.8.1515.43 2025090800430298000_71.8.1515.39 2025090800430298000_71.8.1515.38 2025090800430298000_71.8.1515.37 2025090800430298000_71.8.1515.36 2025090800430298000_71.8.1515.4 Zhang (2025090800430298000_71.8.1515.47) 2019; 234 2025090800430298000_71.8.1515.3 2025090800430298000_71.8.1515.2 2025090800430298000_71.8.1515.1 2025090800430298000_71.8.1515.8 2025090800430298000_71.8.1515.7 2025090800430298000_71.8.1515.6 Sokolova (2025090800430298000_71.8.1515.25) 2019; 421 Ma (2025090800430298000_71.8.1515.45) 2016; 7 2025090800430298000_71.8.1515.5 2025090800430298000_71.8.1515.9 Kuo (2025090800430298000_71.8.1515.26) 2008; 22 2025090800430298000_71.8.1515.31 2025090800430298000_71.8.1515.30 2025090800430298000_71.8.1515.33 2025090800430298000_71.8.1515.32 2025090800430298000_71.8.1515.28 2025090800430298000_71.8.1515.27 2025090800430298000_71.8.1515.29
References_xml	– volume: 22 start-page: 466 year: 2012 ident: R4 article-title: STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.08.010 – volume: 39 start-page: 2707 year: 2020 ident: R46 article-title: Aim2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics publication-title: Oncogene doi: 10.1038/s41388-020-1176-9 – volume: 1817 start-page: 145 year: 2018 ident: R53 article-title: Establishment of human- and mouse-derived gastric primary epithelial cell monolayers from organoids publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-8600-2_15 – volume: 7 start-page: 36185 year: 2016 ident: R45 article-title: Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway publication-title: Oncotarget doi: 10.18632/oncotarget.9154 – volume: 23 start-page: 531 year: 2016 ident: R13 article-title: Toll‐like receptors and tissue remodeling: the pro/cons recent findings publication-title: J Cell Physiol – volume: 15 start-page: 9594 year: 2014 ident: R15 article-title: Nod-Like receptors in intestinal homeostasis and epithelial tissue repair publication-title: Int J Mol Sci doi: 10.3390/ijms15069594 – volume: 289 start-page: 29322 year: 2014 ident: R43 article-title: The microtubule-associated protein EB1 links AIM2 inflammasomes with autophagy-dependent secretion publication-title: J Biol Chem doi: 10.1074/jbc.M114.559153 – volume: 36 start-page: 5134 year: 2017 ident: R21 article-title: Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer publication-title: Oncogene doi: 10.1038/onc.2017.121 – volume: 36 start-page: 23 year: 2015 ident: R37 article-title: Filopodia in cell adhesion, 3D migration and cancer cell invasion publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2015.06.007 – volume: 91 start-page: 601 year: 2013 ident: R12 article-title: The interplay between pathogen-associated and danger-associated molecular patterns: an inflammatory code in cancer? publication-title: Immunol Cell Biol doi: 10.1038/icb.2013.58 – volume: 156 start-page: 680 year: 2015 ident: R39 article-title: Eb1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study publication-title: Endocrinology doi: 10.1210/en.2014-1720 – volume: 140 start-page: 805 year: 2010 ident: R9 article-title: Pattern recognition receptors and inflammation publication-title: Cell doi: 10.1016/j.cell.2010.01.022 – volume: 21 start-page: 906 year: 2015 ident: R18 article-title: Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt publication-title: Nat Med doi: 10.1038/nm.3908 – volume: 5 year: 2014 ident: R20 article-title: Pattern-recognition receptors and gastric cancer publication-title: Front Immunol doi: 10.3389/fimmu.2014.00336 – volume: 22 start-page: 305 year: 2008 ident: R26 article-title: Gamma-H2AX - a novel biomarker for DNA double-strand breaks publication-title: In Vivo – volume: 30 start-page: 437 year: 2007 ident: R50 article-title: Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis publication-title: Int J Oncol – volume: 68 start-page: 394 year: 2018 ident: R3 article-title: Global cancer statistics 2018: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J Clin doi: 10.3322/caac.21492 – volume: 162 start-page: 45 year: 2015 ident: R17 article-title: Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer publication-title: Cell doi: 10.1016/j.cell.2015.06.001 – volume: 79 start-page: 5272 year: 2019 ident: R31 article-title: Serine-phosphorylated STAT3 promotes tumorigenesis via modulation of RNA polymerase transcriptional activity publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-19-0974 – volume: 27 start-page: 218 year: 2008 ident: R49 article-title: Tlr signaling by tumor and immune cells: a double-edged sword publication-title: Oncogene doi: 10.1038/sj.onc.1210904 – volume: 14 start-page: 127 year: 2017 ident: R34 article-title: The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway publication-title: Cell Mol Immunol doi: 10.1038/cmi.2016.35 – volume: 86 start-page: 3 year: 2017 ident: R19 article-title: Transcriptional regulation of inflammasome-associated pattern recognition receptors, and the relevance to disease pathogenesis publication-title: Mol Immunol doi: 10.1016/j.molimm.2016.09.023 – volume: 118 start-page: 1727 year: 2008 ident: R28 article-title: Stat3 and Stat1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice publication-title: J Clin Invest doi: 10.1172/JCI34944 – volume: 11 start-page: 845 year: 2005 ident: R30 article-title: Hyperactivation of stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling publication-title: Nat Med doi: 10.1038/nm1282 – volume: 130 start-page: 3955 year: 2017 ident: R8 article-title: Inflammasome activation and assembly at a glance publication-title: J Cell Sci doi: 10.1242/jcs.207365 – volume: 284 start-page: 30 year: 2009 ident: R40 article-title: Migration and actin protrusion in melanoma cells are regulated by EB1 protein publication-title: Cancer Lett doi: 10.1016/j.canlet.2009.04.007 – volume: 21 start-page: 449 year: 2015 ident: R24 article-title: Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes publication-title: Nat Med doi: 10.1038/nm.3850 – volume: 13 start-page: 453 year: 2013 ident: R7 article-title: The history of toll-like receptors - redefining innate immunity publication-title: Nat Rev Immunol doi: 10.1038/nri3446 – volume: 15 start-page: 453 year: 1997 ident: R27 article-title: Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma publication-title: Oncogene doi: 10.1038/sj.onc.1201206 – volume: 78 start-page: 1293 year: 2018 ident: R6 article-title: Inflammasome adaptor ASC suppresses apoptosis of gastric cancer cells by an IL18-mediated inflammation-independent mechanism publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-17-1887 – volume: 5 year: 2020 ident: R48 article-title: Aim2-mediated/IFN-β–independent regulation of gastric metaplastic lesions via CD8+ T cells publication-title: JCI Insight doi: 10.1172/jci.insight.94035 – volume: 24 start-page: 1459 year: 2018 ident: R29 article-title: Clinical utility of a stat3-regulated miRNA-200 family signature with prognostic potential in early gastric cancer publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-17-2485 – volume: 51 start-page: 27 year: 2019 ident: R2 article-title: Inflammation and cancer: triggers, mechanisms, and consequences publication-title: Immunity doi: 10.1016/j.immuni.2019.06.025 – volume: 10 start-page: 1027 year: 2008 ident: R36 article-title: Identification of genes that regulate epithelial cell migration using an siRNA screening approach publication-title: Nat Cell Biol doi: 10.1038/ncb1762 – volume: 14 start-page: 408 year: 2008 ident: R5 article-title: Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice publication-title: Cancer Cell doi: 10.1016/j.ccr.2008.10.011 – volume: 191 start-page: 3876 year: 2013 ident: R33 article-title: Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation publication-title: J Immunol doi: 10.4049/jimmunol.1300530 – volume: 131 start-page: 1086 year: 2006 ident: R51 article-title: Carcinogenesis in mouse stomach by simultaneous activation of the wnt signaling and prostaglandin E2 pathway publication-title: Gastroenterology doi: 10.1053/j.gastro.2006.07.014 – volume: 1863 start-page: 157 year: 2016 ident: R35 article-title: Characterization of the cell-free DNA released by cultured cancer cells publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2015.10.022 – volume: 1576 start-page: 205 year: 2019 ident: R54 article-title: Oncogenic transformation of human-derived gastric organoids publication-title: Methods Mol Biol doi: 10.1007/7651_2016_4 – volume: 5 year: 2014 ident: R10 article-title: Nod-like receptors: master regulators of inflammation and cancer publication-title: Front Immunol doi: 10.3389/fimmu.2014.00327 – volume: 234 start-page: 20161 year: 2019 ident: R47 article-title: Aim2 promotes non-small-cell lung cancer cell growth through inflammasome-dependent pathway publication-title: J Cell Physiol doi: 10.1002/jcp.28617 – volume: 21 start-page: 2968 year: 2015 ident: R16 article-title: Inflammatory and non-inflammatory roles for toll-like receptors in gastrointestinal cancer publication-title: Curr Pharm Des doi: 10.2174/1381612821666150514104411 – volume: 117 start-page: 60 year: 2007 ident: R1 article-title: Inflammation, atrophy, and gastric cancer publication-title: J Clin Invest doi: 10.1172/JCI30111 – volume: 26 start-page: 273 year: 2009 ident: R38 article-title: The actin cytoskeleton in cancer cell motility publication-title: Clin Exp Metastasis doi: 10.1007/s10585-008-9174-2 – volume: 32 start-page: 1207 year: 2018 ident: R41 article-title: Eb1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration publication-title: Faseb J doi: 10.1096/fj.201700444RR – volume: 10 start-page: 615 year: 2009 ident: R32 article-title: Mouse gastric tumor models with prostaglandin E2 pathway activation show similar gene expression profiles to intestinal-type human gastric cancer publication-title: BMC Genomics doi: 10.1186/1471-2164-10-615 – volume: 9 year: 2019 ident: R44 article-title: The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer publication-title: Sci Rep doi: 10.1038/s41598-019-39636-x – volume: 49 start-page: 1998 year: 2019 ident: R11 article-title: Role of aim2 inflammasome in inflammatory diseases, cancer and infection publication-title: Eur J Immunol doi: 10.1002/eji.201848070 – volume: 11 start-page: 1230 year: 2012 ident: R42 article-title: Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated absence in melanoma 2 (AIM2) inflammasomes publication-title: Mol Cell Proteomics doi: 10.1074/mcp.M112.020594 – volume: 10 year: 2015 ident: R52 article-title: Aim2 drives joint inflammation in a self-DNA triggered model of chronic polyarthritis publication-title: PLoS One doi: 10.1371/journal.pone.0131702 – volume: 108 start-page: 46 year: 2016 ident: R14 article-title: Modulation of endothelial function by toll like receptors publication-title: Pharmacol Res doi: 10.1016/j.phrs.2016.03.038 – volume: 421 start-page: 107 year: 2019 ident: R25 article-title: Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis publication-title: Curr Top Microbiol Immunol doi: 10.1007/978-3-030-15138-6_5 – volume: 19 start-page: 197 year: 2019 ident: R22 article-title: Diverging inflammasome signals in tumorigenesis and potential targeting publication-title: Nat Rev Cancer doi: 10.1038/s41568-019-0123-y – volume: 5 year: 2009 ident: R23 article-title: Oncogenic pathway combinations predict clinical prognosis in gastric cancer publication-title: PLoS Genet doi: 10.1371/journal.pgen.1000676 – volume: 13 start-page: 453 year: 2013 article-title: The history of toll-like receptors - redefining innate immunity publication-title: Nat Rev Immunol doi: 10.1038/nri3446 – volume: 86 start-page: 3 year: 2017 article-title: Transcriptional regulation of inflammasome-associated pattern recognition receptors, and the relevance to disease pathogenesis publication-title: Mol Immunol doi: 10.1016/j.molimm.2016.09.023 – volume: 156 start-page: 680 year: 2015 article-title: Eb1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study publication-title: Endocrinology doi: 10.1210/en.2014-1720 – volume: 5 year: 2009 article-title: Oncogenic pathway combinations predict clinical prognosis in gastric cancer publication-title: PLoS Genet doi: 10.1371/journal.pgen.1000676 – volume: 1863 start-page: 157 year: 2016 article-title: Characterization of the cell-free DNA released by cultured cancer cells publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2015.10.022 – volume: 130 start-page: 3955 year: 2017 article-title: Inflammasome activation and assembly at a glance publication-title: J Cell Sci doi: 10.1242/jcs.207365 – volume: 140 start-page: 805 year: 2010 article-title: Pattern recognition receptors and inflammation publication-title: Cell doi: 10.1016/j.cell.2010.01.022 – volume: 32 start-page: 1207 year: 2018 article-title: Eb1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration publication-title: Faseb J doi: 10.1096/fj.201700444RR – volume: 15 start-page: 453 year: 1997 article-title: Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma publication-title: Oncogene doi: 10.1038/sj.onc.1201206 – volume: 22 start-page: 466 year: 2012 article-title: STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.08.010 – volume: 22 start-page: 305 year: 2008 article-title: Gamma-H2AX - a novel biomarker for DNA double-strand breaks publication-title: In Vivo – volume: 21 start-page: 906 year: 2015 article-title: Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt publication-title: Nat Med doi: 10.1038/nm.3908 – volume: 131 start-page: 1086 year: 2006 article-title: Carcinogenesis in mouse stomach by simultaneous activation of the wnt signaling and prostaglandin E2 pathway publication-title: Gastroenterology doi: 10.1053/j.gastro.2006.07.014 – volume: 11 start-page: 1230 year: 2012 article-title: Interactome-wide analysis identifies end-binding protein 1 as a crucial component for the speck-like particle formation of activated absence in melanoma 2 (AIM2) inflammasomes publication-title: Mol Cell Proteomics doi: 10.1074/mcp.M112.020594 – volume: 162 start-page: 45 year: 2015 article-title: Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer publication-title: Cell doi: 10.1016/j.cell.2015.06.001 – volume: 9 year: 2019 article-title: The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer publication-title: Sci Rep doi: 10.1038/s41598-019-39636-x – volume: 51 start-page: 27 year: 2019 article-title: Inflammation and cancer: triggers, mechanisms, and consequences publication-title: Immunity doi: 10.1016/j.immuni.2019.06.025 – volume: 78 start-page: 1293 year: 2018 article-title: Inflammasome adaptor ASC suppresses apoptosis of gastric cancer cells by an IL18-mediated inflammation-independent mechanism publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-17-1887 – volume: 79 start-page: 5272 year: 2019 article-title: Serine-phosphorylated STAT3 promotes tumorigenesis via modulation of RNA polymerase transcriptional activity publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-19-0974 – volume: 68 start-page: 394 year: 2018 article-title: Global cancer statistics 2018: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: CA Cancer J Clin doi: 10.3322/caac.21492 – volume: 421 start-page: 107 year: 2019 article-title: Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis publication-title: Curr Top Microbiol Immunol doi: 10.1007/978-3-030-15138-6_5 – volume: 234 start-page: 20161 year: 2019 article-title: Aim2 promotes non-small-cell lung cancer cell growth through inflammasome-dependent pathway publication-title: J Cell Physiol doi: 10.1002/jcp.28617 – volume: 49 start-page: 1998 year: 2019 article-title: Role of aim2 inflammasome in inflammatory diseases, cancer and infection publication-title: Eur J Immunol doi: 10.1002/eji.201848070 – volume: 191 start-page: 3876 year: 2013 article-title: Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation publication-title: J Immunol doi: 10.4049/jimmunol.1300530 – volume: 10 start-page: 1027 year: 2008 article-title: Identification of genes that regulate epithelial cell migration using an siRNA screening approach publication-title: Nat Cell Biol doi: 10.1038/ncb1762 – volume: 26 start-page: 273 year: 2009 article-title: The actin cytoskeleton in cancer cell motility publication-title: Clin Exp Metastasis doi: 10.1007/s10585-008-9174-2 – volume: 5 year: 2014 article-title: Nod-like receptors: master regulators of inflammation and cancer publication-title: Front Immunol doi: 10.3389/fimmu.2014.00327 – volume: 24 start-page: 1459 year: 2018 article-title: Clinical utility of a stat3-regulated miRNA-200 family signature with prognostic potential in early gastric cancer publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-17-2485 – volume: 284 start-page: 30 year: 2009 article-title: Migration and actin protrusion in melanoma cells are regulated by EB1 protein publication-title: Cancer Lett doi: 10.1016/j.canlet.2009.04.007 – volume: 19 start-page: 197 year: 2019 article-title: Diverging inflammasome signals in tumorigenesis and potential targeting publication-title: Nat Rev Cancer doi: 10.1038/s41568-019-0123-y – volume: 289 start-page: 29322 year: 2014 article-title: The microtubule-associated protein EB1 links AIM2 inflammasomes with autophagy-dependent secretion publication-title: J Biol Chem doi: 10.1074/jbc.M114.559153 – volume: 36 start-page: 5134 year: 2017 article-title: Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer publication-title: Oncogene doi: 10.1038/onc.2017.121 – volume: 21 start-page: 2968 year: 2015 article-title: Inflammatory and non-inflammatory roles for toll-like receptors in gastrointestinal cancer publication-title: Curr Pharm Des doi: 10.2174/1381612821666150514104411 – volume: 108 start-page: 46 year: 2016 article-title: Modulation of endothelial function by toll like receptors publication-title: Pharmacol Res doi: 10.1016/j.phrs.2016.03.038 – volume: 10 year: 2015 article-title: Aim2 drives joint inflammation in a self-DNA triggered model of chronic polyarthritis publication-title: PLoS One doi: 10.1371/journal.pone.0131702 – volume: 30 start-page: 437 year: 2007 article-title: Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis publication-title: Int J Oncol – volume: 14 start-page: 408 year: 2008 article-title: Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice publication-title: Cancer Cell doi: 10.1016/j.ccr.2008.10.011 – volume: 21 start-page: 449 year: 2015 article-title: Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes publication-title: Nat Med doi: 10.1038/nm.3850 – volume: 39 start-page: 2707 year: 2020 article-title: Aim2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics publication-title: Oncogene doi: 10.1038/s41388-020-1176-9 – volume: 7 start-page: 36185 year: 2016 article-title: Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway publication-title: Oncotarget doi: 10.18632/oncotarget.9154 – volume: 11 start-page: 845 year: 2005 article-title: Hyperactivation of stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling publication-title: Nat Med doi: 10.1038/nm1282 – volume: 10 start-page: 615 year: 2009 article-title: Mouse gastric tumor models with prostaglandin E2 pathway activation show similar gene expression profiles to intestinal-type human gastric cancer publication-title: BMC Genomics doi: 10.1186/1471-2164-10-615 – volume: 14 start-page: 127 year: 2017 article-title: The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway publication-title: Cell Mol Immunol doi: 10.1038/cmi.2016.35 – volume: 15 start-page: 9594 year: 2014 article-title: Nod-Like receptors in intestinal homeostasis and epithelial tissue repair publication-title: Int J Mol Sci doi: 10.3390/ijms15069594 – volume: 5 year: 2020 article-title: Aim2-mediated/IFN-β–independent regulation of gastric metaplastic lesions via CD8+ T cells publication-title: JCI Insight doi: 10.1172/jci.insight.94035 – volume: 91 start-page: 601 year: 2013 article-title: The interplay between pathogen-associated and danger-associated molecular patterns: an inflammatory code in cancer? publication-title: Immunol Cell Biol doi: 10.1038/icb.2013.58 – volume: 23 start-page: 531 year: 2016 article-title: Toll‐like receptors and tissue remodeling: the pro/cons recent findings publication-title: J Cell Physiol – volume: 118 start-page: 1727 year: 2008 article-title: Stat3 and Stat1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice publication-title: J Clin Invest doi: 10.1172/JCI34944 – volume: 27 start-page: 218 year: 2008 article-title: Tlr signaling by tumor and immune cells: a double-edged sword publication-title: Oncogene doi: 10.1038/sj.onc.1210904 – volume: 117 start-page: 60 year: 2007 article-title: Inflammation, atrophy, and gastric cancer publication-title: J Clin Invest doi: 10.1172/JCI30111 – volume: 1576 start-page: 205 year: 2019 article-title: Oncogenic transformation of human-derived gastric organoids publication-title: Methods Mol Biol doi: 10.1007/7651_2016_4 – volume: 1817 start-page: 145 year: 2018 article-title: Establishment of human- and mouse-derived gastric primary epithelial cell monolayers from organoids publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-8600-2_15 – volume: 5 year: 2014 article-title: Pattern-recognition receptors and gastric cancer publication-title: Front Immunol doi: 10.3389/fimmu.2014.00336 – volume: 36 start-page: 23 year: 2015 article-title: Filopodia in cell adhesion, 3D migration and cancer cell invasion publication-title: Curr Opin Cell Biol doi: 10.1016/j.ceb.2015.06.007 – ident: 2025090800430298000_71.8.1515.49 doi: 10.1038/sj.onc.1210904 – ident: 2025090800430298000_71.8.1515.29 doi: 10.1158/1078-0432.CCR-17-2485 – volume: 14 start-page: 127 year: 2017 ident: 2025090800430298000_71.8.1515.34 article-title: The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway publication-title: Cell Mol Immunol doi: 10.1038/cmi.2016.35 – ident: 2025090800430298000_71.8.1515.3 doi: 10.3322/caac.21492 – ident: 2025090800430298000_71.8.1515.23 doi: 10.1371/journal.pgen.1000676 – ident: 2025090800430298000_71.8.1515.38 doi: 10.1007/s10585-008-9174-2 – volume: 1817 start-page: 145 year: 2018 ident: 2025090800430298000_71.8.1515.53 article-title: Establishment of human- and mouse-derived gastric primary epithelial cell monolayers from organoids publication-title: Methods Mol Biol doi: 10.1007/978-1-4939-8600-2_15 – ident: 2025090800430298000_71.8.1515.18 doi: 10.1038/nm.3908 – volume: 234 start-page: 20161 year: 2019 ident: 2025090800430298000_71.8.1515.47 article-title: Aim2 promotes non-small-cell lung cancer cell growth through inflammasome-dependent pathway publication-title: J Cell Physiol doi: 10.1002/jcp.28617 – ident: 2025090800430298000_71.8.1515.40 doi: 10.1016/j.canlet.2009.04.007 – ident: 2025090800430298000_71.8.1515.31 doi: 10.1158/1538-7445.SABCS18-5272 – volume: 1576 start-page: 205 year: 2019 ident: 2025090800430298000_71.8.1515.54 article-title: Oncogenic transformation of human-derived gastric organoids publication-title: Methods Mol Biol doi: 10.1007/7651_2016_4 – ident: 2025090800430298000_71.8.1515.7 doi: 10.1038/nri3446 – volume: 5 year: 2020 ident: 2025090800430298000_71.8.1515.48 article-title: Aim2-mediated/IFN-β–independent regulation of gastric metaplastic lesions via CD8+ T cells publication-title: JCI Insight doi: 10.1172/jci.insight.94035 – volume: 86 start-page: 3 year: 2017 ident: 2025090800430298000_71.8.1515.19 article-title: Transcriptional regulation of inflammasome-associated pattern recognition receptors, and the relevance to disease pathogenesis publication-title: Mol Immunol doi: 10.1016/j.molimm.2016.09.023 – ident: 2025090800430298000_71.8.1515.9 doi: 10.1016/j.cell.2010.01.022 – ident: 2025090800430298000_71.8.1515.27 doi: 10.1038/sj.onc.1201206 – volume: 7 start-page: 36185 year: 2016 ident: 2025090800430298000_71.8.1515.45 article-title: Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway publication-title: Oncotarget doi: 10.18632/oncotarget.9154 – ident: 2025090800430298000_71.8.1515.43 doi: 10.1074/jbc.M114.559153 – ident: 2025090800430298000_71.8.1515.11 doi: 10.1002/eji.201848070 – ident: 2025090800430298000_71.8.1515.39 doi: 10.1210/en.2014-1720 – ident: 2025090800430298000_71.8.1515.52 doi: 10.1371/journal.pone.0131702 – ident: 2025090800430298000_71.8.1515.6 doi: 10.1158/0008-5472.CAN-17-1887 – ident: 2025090800430298000_71.8.1515.4 doi: 10.1016/j.ccr.2012.08.010 – ident: 2025090800430298000_71.8.1515.30 doi: 10.1038/nm1282 – ident: 2025090800430298000_71.8.1515.1 doi: 10.1172/JCI30111 – volume: 23 start-page: 531 year: 2016 ident: 2025090800430298000_71.8.1515.13 article-title: Toll‐like receptors and tissue remodeling: the pro/cons recent findings publication-title: J Cell Physiol doi: 10.1002/jcp.25124 – volume: 5 year: 2014 ident: 2025090800430298000_71.8.1515.20 article-title: Pattern-recognition receptors and gastric cancer publication-title: Front Immunol – ident: 2025090800430298000_71.8.1515.2 doi: 10.1016/j.immuni.2019.06.025 – ident: 2025090800430298000_71.8.1515.5 doi: 10.1016/j.ccr.2008.10.011 – ident: 2025090800430298000_71.8.1515.36 doi: 10.1038/ncb1762 – ident: 2025090800430298000_71.8.1515.24 doi: 10.1038/nm.3850 – volume: 108 start-page: 46 year: 2016 ident: 2025090800430298000_71.8.1515.14 article-title: Modulation of endothelial function by toll like receptors publication-title: Pharmacol Res doi: 10.1016/j.phrs.2016.03.038 – volume: 1863 start-page: 157 year: 2016 ident: 2025090800430298000_71.8.1515.35 article-title: Characterization of the cell-free DNA released by cultured cancer cells publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2015.10.022 – ident: 2025090800430298000_71.8.1515.16 doi: 10.2174/1381612821666150514104411 – ident: 2025090800430298000_71.8.1515.28 doi: 10.1172/JCI34944 – volume: 421 start-page: 107 year: 2019 ident: 2025090800430298000_71.8.1515.25 article-title: Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis publication-title: Curr Top Microbiol Immunol – ident: 2025090800430298000_71.8.1515.37 doi: 10.1016/j.ceb.2015.06.007 – volume: 39 start-page: 2707 year: 2020 ident: 2025090800430298000_71.8.1515.46 article-title: Aim2 promotes the development of non-small cell lung cancer by modulating mitochondrial dynamics publication-title: Oncogene doi: 10.1038/s41388-020-1176-9 – volume: 9 year: 2019 ident: 2025090800430298000_71.8.1515.44 article-title: The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer publication-title: Sci Rep doi: 10.1038/s41598-019-39636-x – ident: 2025090800430298000_71.8.1515.8 doi: 10.1242/jcs.207365 – volume: 36 start-page: 5134 year: 2017 ident: 2025090800430298000_71.8.1515.21 article-title: Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer publication-title: Oncogene doi: 10.1038/onc.2017.121 – ident: 2025090800430298000_71.8.1515.32 doi: 10.1186/1471-2164-10-615 – ident: 2025090800430298000_71.8.1515.51 doi: 10.1053/j.gastro.2006.07.014 – volume: 32 start-page: 1207 year: 2018 ident: 2025090800430298000_71.8.1515.41 article-title: Eb1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration publication-title: Faseb J doi: 10.1096/fj.201700444RR – volume: 30 start-page: 437 year: 2007 ident: 2025090800430298000_71.8.1515.50 article-title: Expression of p-STAT3 in human gastric carcinoma: significant correlation in tumour invasion and prognosis publication-title: Int J Oncol – ident: 2025090800430298000_71.8.1515.22 doi: 10.1038/s41568-019-0123-y – ident: 2025090800430298000_71.8.1515.17 doi: 10.1016/j.cell.2015.06.001 – ident: 2025090800430298000_71.8.1515.33 doi: 10.4049/jimmunol.1300530 – volume: 22 start-page: 305 year: 2008 ident: 2025090800430298000_71.8.1515.26 article-title: Gamma-H2AX - a novel biomarker for DNA double-strand breaks publication-title: In Vivo – ident: 2025090800430298000_71.8.1515.12 doi: 10.1038/icb.2013.58 – ident: 2025090800430298000_71.8.1515.15 doi: 10.3390/ijms15069594 – ident: 2025090800430298000_71.8.1515.42 doi: 10.1074/mcp.M112.020594 – ident: 2025090800430298000_71.8.1515.10 doi: 10.3389/fimmu.2014.00327
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Snippet	ObjectiveThe absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA sensor promotes the pathogenesis of autoimmune and chronic inflammatory... The absent in melanoma 2 (AIM2) cytosolic pattern recognition receptor and DNA sensor promotes the pathogenesis of autoimmune and chronic inflammatory diseases...
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SubjectTerms	Animal models Apoptosis Biopsy Carcinogenesis Caspase-1 Cell adhesion & migration Cell migration Cytokines Deoxyribonucleic acid DNA Epithelial cells Epithelium Gastric cancer Gene expression Genetic engineering immunology Inflammasomes Inflammation Inflammatory diseases Innate immunity Interleukin 11 Medical research Melanoma molecular biology Pathogenesis Patients Pattern recognition Pattern recognition receptors Protein expression Proteins Sensors Stat3 protein Stomach Survival analysis Therapeutic targets Tumorigenesis Tumors Xenografts
Title	STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis
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