Molecular phenotypes of critical illness confer prognostic and biological enrichment in sub-Saharan Africa: a prospective cohort study from Uganda

The generalisability of critical illness molecular phenotypes to low- and middle-income countries (LMICs) is unknown. We show that molecular phenotypes derived in high-income countries (hyperinflammatory and hypoinflammatory, reactive and uninflamed) stratify sepsis patients in Uganda by physiologic...

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Bibliographic Details
Published in:	Thorax Vol. 80; no. 3; pp. 175 - 179
Main Authors:	Cummings, Matthew J, Lutwama, Julius J, Tomoiaga, Alin S, Owor, Nicholas, Lu, Xuan, Ross, Jesse E, Muwanga, Moses, Nsereko, Christopher, Nayiga, Irene, Nie, Kai, Kayiwa, John, Che, Xiaoyu, Wayengera, Misaki, Kim-Schulze, Seunghee, Lipkin, W Ian, O’Donnell, Max R, Bakamutumaho, Barnabas
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd and British Thoracic Society 17.02.2025 BMJ Publishing Group LTD
Subjects:	Adult Biomarkers Blood pressure Cohort analysis Critical care Critical Illness Cytokine Biology Female Genotype & phenotype Heart rate HIV Human immunodeficiency virus Humans Hypotension Illnesses Infections Influenza Malaria Male Mann-Whitney U test Medical prognosis Middle Aged Mortality Oxygen saturation Pathogens Patients Phenotype Probability Prognosis Prospective Studies Protein expression Regression analysis Sepsis Sepsis - mortality Severity of Illness Index Tuberculosis Uganda - epidemiology Urine Variables Uganda Africa Critical Care Cytokine Biology
ISSN:	0040-6376, 1468-3296, 1468-3296
Online Access:	Get full text
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