Food allergies are associated with increased disease activity in multiple sclerosis

ObjectiveThe association between allergy and multiple sclerosis (MS) is still unclear. In our study, we assessed the association between a self-reported history of allergic conditions with MS clinical and MRI disease activity.MethodsA subset of 1349 patients enrolled in the Comprehensive Longitudina...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of neurology, neurosurgery and psychiatry Jg. 90; H. 6; S. 629 - 635
Hauptverfasser:	Fakih, Rami, Diaz-Cruz, Camilo, Chua, Alicia S, Gonzalez, Cindy, Healy, Brian C, Sattarnezhad, Neda, Glanz, Bonnie I, Weiner, Howard L, Chitnis, Tanuja
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England BMJ Publishing Group LTD 01.06.2019
Schlagworte:	Anaphylaxis Asthma Brain - diagnostic imaging Comorbidity Female Food allergies Food Hypersensitivity - complications Health risk assessment Humans Immune system Immunoglobulins Immunology Immunotherapy Longitudinal Studies Magnetic Resonance Imaging Male Middle Aged Multiple sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - etiology Neuroimaging Patients Questionnaires Severity of Illness Index Studies Surveys and Questionnaires United States > US disease activity relapses MRI food allergy multiple sclerosis
ISSN:	0022-3050, 1468-330X, 1468-330X
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	ObjectiveThe association between allergy and multiple sclerosis (MS) is still unclear. In our study, we assessed the association between a self-reported history of allergic conditions with MS clinical and MRI disease activity.MethodsA subset of 1349 patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women’s Hospital (CLIMB) study completed a self-administered questionnaire on environmental, food and drug allergies. Patients were distributed among four allergy groups: (1) environmental, (2) food, (3) drug, (4) no known allergies (NKA). Clinical (number of attacks, expanded disability status scale (EDSS), MS severity score (MSSS)) and radiological variables (presence of gadolinium-enhancing lesions and lesion count), and their associations with the different allergy groups or those with NKA, were assessed.ResultsThe food allergy group had a 1.38 times higher rate for cumulative number of attacks compared with the NKA group (P=0.0062); this difference remained significant in the adjusted analysis (relapse rate ratio 1.27, P=0.0305). The food allergy group showed more than twice the likelihood (OR 2.53, P=0.0096) of having gadolinium-enhancing lesions on MRI. The environmental and drug allergy groups did not show significant differences when compared with the NKA group. The EDSS and MSSS were not affected by any type of allergy.ConclusionsMS patients with food allergy had more relapses and a higher likelihood of gadolinium-enhancing lesions compared with patients with no known allergy. Future prospective studies are needed to confirm our findings and investigate underlying biological mechanisms, which may unveil new therapeutic and preventative strategies for MS.
AbstractList	The association between allergy and multiple sclerosis (MS) is still unclear. In our study, we assessed the association between a self-reported history of allergic conditions with MS clinical and MRI disease activity.OBJECTIVEThe association between allergy and multiple sclerosis (MS) is still unclear. In our study, we assessed the association between a self-reported history of allergic conditions with MS clinical and MRI disease activity.A subset of 1349 patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB) study completed a self-administered questionnaire on environmental, food and drug allergies. Patients were distributed among four allergy groups: (1) environmental, (2) food, (3) drug, (4) no known allergies (NKA). Clinical (number of attacks, expanded disability status scale (EDSS), MS severity score (MSSS)) and radiological variables (presence of gadolinium-enhancing lesions and lesion count), and their associations with the different allergy groups or those with NKA, were assessed.METHODSA subset of 1349 patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB) study completed a self-administered questionnaire on environmental, food and drug allergies. Patients were distributed among four allergy groups: (1) environmental, (2) food, (3) drug, (4) no known allergies (NKA). Clinical (number of attacks, expanded disability status scale (EDSS), MS severity score (MSSS)) and radiological variables (presence of gadolinium-enhancing lesions and lesion count), and their associations with the different allergy groups or those with NKA, were assessed.The food allergy group had a 1.38 times higher rate for cumulative number of attacks compared with the NKA group (P=0.0062); this difference remained significant in the adjusted analysis (relapse rate ratio 1.27, P=0.0305). The food allergy group showed more than twice the likelihood (OR 2.53, P=0.0096) of having gadolinium-enhancing lesions on MRI. The environmental and drug allergy groups did not show significant differences when compared with the NKA group. The EDSS and MSSS were not affected by any type of allergy.RESULTSThe food allergy group had a 1.38 times higher rate for cumulative number of attacks compared with the NKA group (P=0.0062); this difference remained significant in the adjusted analysis (relapse rate ratio 1.27, P=0.0305). The food allergy group showed more than twice the likelihood (OR 2.53, P=0.0096) of having gadolinium-enhancing lesions on MRI. The environmental and drug allergy groups did not show significant differences when compared with the NKA group. The EDSS and MSSS were not affected by any type of allergy.MS patients with food allergy had more relapses and a higher likelihood of gadolinium-enhancing lesions compared with patients with no known allergy. Future prospective studies are needed to confirm our findings and investigate underlying biological mechanisms, which may unveil new therapeutic and preventative strategies for MS.CONCLUSIONSMS patients with food allergy had more relapses and a higher likelihood of gadolinium-enhancing lesions compared with patients with no known allergy. Future prospective studies are needed to confirm our findings and investigate underlying biological mechanisms, which may unveil new therapeutic and preventative strategies for MS. ObjectiveThe association between allergy and multiple sclerosis (MS) is still unclear. In our study, we assessed the association between a self-reported history of allergic conditions with MS clinical and MRI disease activity.MethodsA subset of 1349 patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women’s Hospital (CLIMB) study completed a self-administered questionnaire on environmental, food and drug allergies. Patients were distributed among four allergy groups: (1) environmental, (2) food, (3) drug, (4) no known allergies (NKA). Clinical (number of attacks, expanded disability status scale (EDSS), MS severity score (MSSS)) and radiological variables (presence of gadolinium-enhancing lesions and lesion count), and their associations with the different allergy groups or those with NKA, were assessed.ResultsThe food allergy group had a 1.38 times higher rate for cumulative number of attacks compared with the NKA group (P=0.0062); this difference remained significant in the adjusted analysis (relapse rate ratio 1.27, P=0.0305). The food allergy group showed more than twice the likelihood (OR 2.53, P=0.0096) of having gadolinium-enhancing lesions on MRI. The environmental and drug allergy groups did not show significant differences when compared with the NKA group. The EDSS and MSSS were not affected by any type of allergy.ConclusionsMS patients with food allergy had more relapses and a higher likelihood of gadolinium-enhancing lesions compared with patients with no known allergy. Future prospective studies are needed to confirm our findings and investigate underlying biological mechanisms, which may unveil new therapeutic and preventative strategies for MS. The association between allergy and multiple sclerosis (MS) is still unclear. In our study, we assessed the association between a self-reported history of allergic conditions with MS clinical and MRI disease activity. A subset of 1349 patients enrolled in the Comprehensive Longitudinal Investigation of Multiple Sclerosis at the Brigham and Women's Hospital (CLIMB) study completed a self-administered questionnaire on environmental, food and drug allergies. Patients were distributed among four allergy groups: (1) environmental, (2) food, (3) drug, (4) no known allergies (NKA). Clinical (number of attacks, expanded disability status scale (EDSS), MS severity score (MSSS)) and radiological variables (presence of gadolinium-enhancing lesions and lesion count), and their associations with the different allergy groups or those with NKA, were assessed. The food allergy group had a 1.38 times higher rate for cumulative number of attacks compared with the NKA group (P=0.0062); this difference remained significant in the adjusted analysis (relapse rate ratio 1.27, P=0.0305). The food allergy group showed more than twice the likelihood (OR 2.53, P=0.0096) of having gadolinium-enhancing lesions on MRI. The environmental and drug allergy groups did not show significant differences when compared with the NKA group. The EDSS and MSSS were not affected by any type of allergy. MS patients with food allergy had more relapses and a higher likelihood of gadolinium-enhancing lesions compared with patients with no known allergy. Future prospective studies are needed to confirm our findings and investigate underlying biological mechanisms, which may unveil new therapeutic and preventative strategies for MS.
Author	Healy, Brian C Sattarnezhad, Neda Chitnis, Tanuja Fakih, Rami Glanz, Bonnie I Diaz-Cruz, Camilo Weiner, Howard L Gonzalez, Cindy Chua, Alicia S
Author_xml	– sequence: 1 givenname: Rami surname: Fakih fullname: Fakih, Rami email: tchitnis@rics.bwh.harvard.edu organization: Partners MS Center, Brigham and Women's Hospital (BWH), Harvard Medical School, Boston, Massachusetts, USA – sequence: 2 givenname: Camilo surname: Diaz-Cruz fullname: Diaz-Cruz, Camilo email: tchitnis@rics.bwh.harvard.edu – sequence: 3 givenname: Alicia S surname: Chua fullname: Chua, Alicia S email: tchitnis@rics.bwh.harvard.edu – sequence: 4 givenname: Cindy surname: Gonzalez fullname: Gonzalez, Cindy email: tchitnis@rics.bwh.harvard.edu – sequence: 5 givenname: Brian C surname: Healy fullname: Healy, Brian C email: tchitnis@rics.bwh.harvard.edu organization: Partners MS Center, Brigham and Women's Hospital (BWH), Harvard Medical School, Boston, Massachusetts, USA – sequence: 6 givenname: Neda surname: Sattarnezhad fullname: Sattarnezhad, Neda email: tchitnis@rics.bwh.harvard.edu – sequence: 7 givenname: Bonnie I surname: Glanz fullname: Glanz, Bonnie I email: tchitnis@rics.bwh.harvard.edu – sequence: 8 givenname: Howard L surname: Weiner fullname: Weiner, Howard L email: tchitnis@rics.bwh.harvard.edu – sequence: 9 givenname: Tanuja surname: Chitnis fullname: Chitnis, Tanuja email: tchitnis@rics.bwh.harvard.edu
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30563943$$D View this record in MEDLINE/PubMed
BookMark	eNqFkUtLxDAUhYMoOj72rqTgRpBqHm1sliK-QHChgrtwJ7nVDG0zJqnivzdldONCQyC5yXcOuTnbZH3wAxKyz-gJY0KeLoZhWXLKmlIwJShbIzNWyVwJ-rxOZpRyXgpa0y2yHeOCTqNRm2Qrn0mhKjEjD1fe2wK6DsOLw1hAwAJi9MZBQlt8uPRauMEEhJhL6-K0KcAk9-7SZ74q-rFLbtlhEU028dHFXbLRQhdx73vdIU9Xl48XN-Xd_fXtxfldORdSpLKxFmusAWUlKjCqEaJizDbtGa25lWIOtq3OsOZK5j5AtiAtV4yDNVZSVYsdcrTyXQb_NmJMunfRYNfBgH6MmrO6qfNUKqOHv9CFH8OQX6c551JUSlGeqYNvapz3aPUyuB7Cp_75rgzIFWByozFgq41LkJwfUgDXaUb1lIuectFTLnqVSxbSX8If7z8kxyvJvF_8T38B1jqdew
CitedBy_id	crossref_primary_10_1183_13993003_00476_2019 crossref_primary_10_1186_s12883_022_02913_w crossref_primary_10_1016_j_jemermed_2023_12_003 crossref_primary_10_3390_allergies5030026 crossref_primary_10_4103_1673_5374_282238 crossref_primary_10_1080_14737175_2021_1978843 crossref_primary_10_1136_jnnp_2018_319585 crossref_primary_10_3390_cells13161316 crossref_primary_10_3390_allergies5020018
Cites_doi	10.3174/ajnr.A0795 10.1007/s11910-014-0492-2 10.1186/1743-7075-6-22 10.1002/ana.22366 10.1016/j.cell.2014.12.020 10.1056/NEJMoa011341 10.1016/j.autrev.2006.02.012 10.1001/jamaneurol.2016.5197 10.1093/glycob/cwi053 10.1007/s13311-016-0480-0 10.1016/j.smim.2017.08.008 10.1038/ncomms12015 10.1212/01.WNL.0000156155.19270.F8 10.1212/WNL.0b013e3181f0734c 10.1038/nri.2016.111 10.1016/j.iac.2017.01.010 10.1097/WCO.0b013e32815610c2 10.1111/j.1600-0404.2007.00898.x 10.1016/j.clim.2013.05.012 10.1111/j.1600-0404.2010.01355.x 10.1177/1352458509106211 10.1111/j.1365-2249.2006.03235.x 10.1016/j.jns.2017.02.041 10.1111/all.13132 10.1038/nature10554 10.1002/ana.23758 10.1111/jon.12307 10.1111/apt.12984 10.1038/nature13835 10.1038/nature12199 10.2500/aap.2013.34.3646 10.1191/1352458504ms1087oa 10.1093/brain/awm329 10.1136/jnnp.2011.242115 10.1038/nrneurol.2016.187
ContentType	Journal Article
Copyright	Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. 2019 Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Copyright_xml	– notice: Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. – notice: 2019 Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7RV 7X7 7XB 88E 88G 88I 8AF 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR BTHHO CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. KB0 M0S M1P M2M M2P NAPCQ PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7X8
DOI	10.1136/jnnp-2018-319301
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nursing & Allied Health Database Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central BMJ Journals ProQuest One ProQuest Central Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) ProQuest Health & Medical Collection PML(ProQuest Medical Library) Psychology Database Science Database Nursing & Allied Health Premium ProQuest Databases ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China One Psychology ProQuest Central Basic MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest AP Science ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition BMJ Journals ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic ProQuest One Psychology MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1468-330X
EndPage	635
ExternalDocumentID	30563943 10_1136_jnnp_2018_319301 jnnp
Genre	Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	United States--US
GeographicLocations_xml	– name: United States--US
GroupedDBID	--- .55 .GJ .VT 0R~ 18M 29L 2WC 354 39C 3O- 4.4 40O 41~ 53G 5GY 5RE 5VS 7RV 7X7 7~S 88E 88I 8AF 8FI 8FJ 8R4 8R5 AAHLL AAKAS AAOJX AAUVZ AAWJN AAWTL ABAAH ABIVO ABJNI ABKDF ABMQD ABOCM ABUWG ABVAJ ACGFO ACGFS ACGOD ACGTL ACHTP ACMFJ ACOAB ACOFX ACQSR ACTZY ADBBV ADCEG ADFRT ADUGQ ADZCM AEKJL AENEX AFKRA AFWFF AGQPQ AHMBA AHNKE AHQMW AI. AJYBZ AKKEP ALIPV ALMA_UNASSIGNED_HOLDINGS AZFZN AZQEC BAWUL BENPR BLJBA BOMFT BPHCQ BTFSW BTHHO BVXVI C45 CAG CCPQU COF CS3 CXRWF DIK DU5 DWQXO E3Z EBS EJD EX3 F5P FEDTE FYUFA GNUQQ GX1 H13 HAJ HCIFZ HMCUK HVGLF HYE HZ~ IAO IEA IHR INH INR IOF IPO IPY ITC J5H KQ8 L7B M1P M2M M2P N9A NAPCQ NTWIH NXWIF O9- OK1 OMB OMG OVD P2P PCD PHGZT PQQKQ PROAC PSQYO PSYQQ Q2X R53 RHI RMJ RPM RV8 SJN TEORI TR2 UKHRP UPT UYXKK V24 VH1 VM9 VVN W8F WH7 WOW X7M YFH YQT YQY ZGI AAYXX ACQHZ AERUA AFFHD CITATION PHGZM PJZUB PPXIY 3V. CGR CUY CVF ECM EIF NPM PKN RHF YCJ 7XB 8FK ADGHP K9. PKEHL PQEST PQUKI PRINS Q9U 7X8
ID	FETCH-LOGICAL-b363t-8dde5e5ae6434ac9833411d8f7052d63badf47e5296022a6fa6d2912adcd60953
IEDL.DBID	7RV
ISICitedReferencesCount	8
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000471118100004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0022-3050 1468-330X
IngestDate	Sun Nov 09 12:48:13 EST 2025 Tue Oct 07 06:55:19 EDT 2025 Wed Feb 19 02:31:17 EST 2025 Sat Nov 29 02:37:23 EST 2025 Tue Nov 18 20:53:27 EST 2025 Fri Apr 25 03:31:51 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Issue	6
Keywords	disease activity relapses MRI food allergy multiple sclerosis
Language	English
License	Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-b363t-8dde5e5ae6434ac9833411d8f7052d63badf47e5296022a6fa6d2912adcd60953
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
PMID	30563943
PQID	2226349902
PQPubID	2041879
PageCount	7
ParticipantIDs	proquest_miscellaneous_2158558599 proquest_journals_2226349902 pubmed_primary_30563943 crossref_citationtrail_10_1136_jnnp_2018_319301 crossref_primary_10_1136_jnnp_2018_319301 bmj_primary_10_1136_jnnp_2018_319301
PublicationCentury	2000
PublicationDate	20190600 2019-06-00 20190601
PublicationDateYYYYMMDD	2019-06-01
PublicationDate_xml	– month: 06 year: 2019 text: 20190600
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England – name: London
PublicationTitle	Journal of neurology, neurosurgery and psychiatry
PublicationTitleAlternate	J Neurol Neurosurg Psychiatry
PublicationYear	2019
Publisher	BMJ Publishing Group LTD
Publisher_xml	– name: BMJ Publishing Group LTD
References	Ponsonby, Dwyer, van der Mei 2006; 146 Olsson, Barcellos, Alfredsson 2017; 13 Yu, Freeland, Nadeau 2016; 16 Liguori, Meier, Hildenbrand 2011; 82 Regev, Healy, Khalid 2017; 74 Gauthier, Glanz, Mandel 2006; 5 Farh, Marson, Zhu 2015; 518 Duan, Hildenbrand, Sampat 2008; 29 Solaro, Messmer Uccelli, Guglieri 2001; 248 Turnbull, Adams, Gorard 2015; 41 Brodin, Jojic, Gao 2015; 160 Karimi, Modarresi, Sahraian 2013; 12 Alonso, Hernán, Ascherio 2008; 117 Pedotti, Farinotti, Falcone 2009; 15 Jangi, Gandhi, Cox 2016; 7 Teixeira, Bittencourt, Ferreira 2013; 148 Fisniku, Brex, Altmann 2008; 131 Giovannoni, Ebers 2007; 20 Monteiro, Souza-Machado, Menezes 2011; 123 Brex, Ciccarelli, O'Riordan 2002; 346 Meier, Balashov, Healy 2010; 75 Ramasamy, Vannucci, Yan 2005; 15 Li, Ju, Frieri 2013; 34 Roxburgh, Seaman, Masterman 2005; 64 Vojdani, IgE 2009; 6 Freeland, Manohar, Andorf 2017; 30 Otani, Nadeau 2017; 37 Bhargava, Mowry 2014; 14 Oommen, Tauhid, Healy 2016; 26 Berer, Mues, Koutrolos 2011; 479 Polman, Reingold, Banwell 2011; 69 Bourne, Waltz, Casper 2017; 375 Muraro, Lemanske, Castells 2017; 72 Roychoudhuri, Hirahara, Mousavi 2013; 498 Edwards, Constantinescu 2004; 10 Bermel, You, Foulds 2013; 73 Escribano, Medina-Fernández, Aguilar-Luque 2017; 14 Oommen (2020050722344376000_90.6.629.16) 2016; 26 Karimi (2020050722344376000_90.6.629.5) 2013; 12 2020050722344376000_90.6.629.11 2020050722344376000_90.6.629.33 2020050722344376000_90.6.629.12 2020050722344376000_90.6.629.34 2020050722344376000_90.6.629.32 2020050722344376000_90.6.629.15 2020050722344376000_90.6.629.13 Regev (2020050722344376000_90.6.629.17) 2017; 74 2020050722344376000_90.6.629.35 2020050722344376000_90.6.629.14 2020050722344376000_90.6.629.1 2020050722344376000_90.6.629.18 Alonso (2020050722344376000_90.6.629.8) 2008; 117 Muraro (2020050722344376000_90.6.629.19) 2017; 72 2020050722344376000_90.6.629.6 2020050722344376000_90.6.629.7 2020050722344376000_90.6.629.4 Yu (2020050722344376000_90.6.629.23) 2016; 16 Li (2020050722344376000_90.6.629.26) 2013; 34 2020050722344376000_90.6.629.2 Solaro (2020050722344376000_90.6.629.3) 2001; 248 Otani (2020050722344376000_90.6.629.37) 2017; 37 Freeland (2020050722344376000_90.6.629.36) 2017; 30 2020050722344376000_90.6.629.22 2020050722344376000_90.6.629.20 2020050722344376000_90.6.629.21 2020050722344376000_90.6.629.27 Escribano (2020050722344376000_90.6.629.30) 2017; 14 2020050722344376000_90.6.629.24 Monteiro (2020050722344376000_90.6.629.9) 2011; 123 2020050722344376000_90.6.629.25 2020050722344376000_90.6.629.28 2020050722344376000_90.6.629.29 Teixeira (2020050722344376000_90.6.629.31) 2013; 148 Bourne (2020050722344376000_90.6.629.10) 2017; 375 30630959 - J Neurol Neurosurg Psychiatry. 2019 Jun;90(6):625
References_xml	– volume: 29 start-page: 340 year: 2008 article-title: Segmentation of subtraction images for the measurement of lesion change in multiple sclerosis publication-title: AJNR Am J Neuroradiol doi: 10.3174/ajnr.A0795 – volume: 14 year: 2014 article-title: Gut microbiome and multiple sclerosis publication-title: Curr Neurol Neurosci Rep doi: 10.1007/s11910-014-0492-2 – volume: 6 year: 2009 article-title: Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens publication-title: Nutr Metab doi: 10.1186/1743-7075-6-22 – volume: 69 start-page: 292 year: 2011 article-title: Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria publication-title: Ann Neurol doi: 10.1002/ana.22366 – volume: 160 start-page: 37 year: 2015 article-title: Variation in the human immune system is largely driven by non-heritable influences publication-title: Cell doi: 10.1016/j.cell.2014.12.020 – volume: 346 start-page: 158 year: 2002 article-title: A longitudinal study of abnormalities on MRI and disability from multiple sclerosis publication-title: N Engl J Med doi: 10.1056/NEJMoa011341 – volume: 5 start-page: 532 year: 2006 article-title: A model for the comprehensive investigation of a chronic autoimmune disease: the multiple sclerosis CLIMB study publication-title: Autoimmun Rev doi: 10.1016/j.autrev.2006.02.012 – volume: 74 start-page: 275 year: 2017 article-title: Association between serum MicroRNAs and magnetic resonance imaging measures of multiple sclerosis severity publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2016.5197 – volume: 15 start-page: 16R year: 2005 article-title: Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation publication-title: Glycobiology doi: 10.1093/glycob/cwi053 – volume: 14 start-page: 199 year: 2017 article-title: Lipopolysaccharide binding protein and oxidative stress in a multiple sclerosis model publication-title: Neurotherapeutics doi: 10.1007/s13311-016-0480-0 – volume: 30 start-page: 36 year: 2017 article-title: Oral immunotherapy for food allergy publication-title: Semin Immunol doi: 10.1016/j.smim.2017.08.008 – volume: 7 year: 2016 article-title: Alterations of the human gut microbiome in multiple sclerosis publication-title: Nat Commun doi: 10.1038/ncomms12015 – volume: 64 start-page: 1144 year: 2005 article-title: Multiple Sclerosis Severity Score: using disability and disease duration to rate disease severity publication-title: Neurology doi: 10.1212/01.WNL.0000156155.19270.F8 – volume: 75 start-page: 799 year: 2010 article-title: Seasonal prevalence of MS disease activity publication-title: Neurology doi: 10.1212/WNL.0b013e3181f0734c – volume: 16 start-page: 751 year: 2016 article-title: Food allergy: immune mechanisms, diagnosis and immunotherapy publication-title: Nat Rev Immunol doi: 10.1038/nri.2016.111 – volume: 37 start-page: 369 year: 2017 article-title: Biologic therapies for immunoglobulin E-mediated food allergy and eosinophilic esophagitis publication-title: Immunol Allergy Clin North Am doi: 10.1016/j.iac.2017.01.010 – volume: 20 start-page: 261 year: 2007 article-title: Multiple sclerosis: the environment and causation publication-title: Curr Opin Neurol doi: 10.1097/WCO.0b013e32815610c2 – volume: 117 start-page: 15 year: 2008 article-title: Allergy, family history of autoimmune diseases, and the risk of multiple sclerosis publication-title: Acta Neurol Scand doi: 10.1111/j.1600-0404.2007.00898.x – volume: 148 start-page: 209 year: 2013 article-title: Low sensitivity to glucocorticoid inhibition of in vitro Th17-related cytokine production in multiple sclerosis patients is related to elevated plasma lipopolysaccharide levels publication-title: Clin Immunol doi: 10.1016/j.clim.2013.05.012 – volume: 123 start-page: 1 year: 2011 article-title: Association between allergies and multiple sclerosis: a systematic review and meta-analysis publication-title: Acta Neurol Scand doi: 10.1111/j.1600-0404.2010.01355.x – volume: 15 start-page: 899 year: 2009 article-title: Allergy and multiple sclerosis: a population-based case-control study publication-title: Mult Scler doi: 10.1177/1352458509106211 – volume: 12 start-page: 182 year: 2013 article-title: The relation of multiple sclerosis with allergy and atopy: a case control study publication-title: Iran J Allergy Asthma Immunol – volume: 146 start-page: 463 year: 2006 article-title: Asthma onset prior to multiple sclerosis and the contribution of sibling exposure in early life publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2006.03235.x – volume: 375 start-page: 371 year: 2017 article-title: Evaluating the association of allergies with multiple sclerosis susceptibility risk and disease activity in a pediatric population publication-title: J Neurol Sci doi: 10.1016/j.jns.2017.02.041 – volume: 72 start-page: 1006 year: 2017 article-title: Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology publication-title: Allergy doi: 10.1111/all.13132 – volume: 479 start-page: 538 year: 2011 article-title: Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination publication-title: Nature doi: 10.1038/nature10554 – volume: 73 start-page: 95 year: 2013 article-title: Predictors of long-term outcome in multiple sclerosis patients treated with interferon β publication-title: Ann Neurol doi: 10.1002/ana.23758 – volume: 248 start-page: 239 year: 2001 article-title: Prevalence of atopy in multiple sclerosis patients: a case-control study publication-title: J Neurol – volume: 26 start-page: 184 year: 2016 article-title: The effect of fingolimod on conversion of acute gadolinium-enhancing lesions to chronic T1 hypointensities in multiple sclerosis publication-title: J Neuroimaging doi: 10.1111/jon.12307 – volume: 41 start-page: 3 year: 2015 article-title: Review article: the diagnosis and management of food allergy and food intolerances publication-title: Aliment Pharmacol Ther doi: 10.1111/apt.12984 – volume: 518 start-page: 337 year: 2015 article-title: Genetic and epigenetic fine mapping of causal autoimmune disease variants publication-title: Nature doi: 10.1038/nature13835 – volume: 498 start-page: 506 year: 2013 article-title: BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis publication-title: Nature doi: 10.1038/nature12199 – volume: 34 start-page: 21 year: 2013 article-title: The T-cell immunoglobulin and mucin domain (Tim) gene family in asthma, allergy, and autoimmunity publication-title: Allergy Asthma Proc doi: 10.2500/aap.2013.34.3646 – volume: 10 start-page: 575 year: 2004 article-title: A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic publication-title: Mult Scler doi: 10.1191/1352458504ms1087oa – volume: 131 start-page: 808 issue: Pt 3 year: 2008 article-title: Disability and T2 MRI lesions: a 20-year follow-up of patients with relapse onset of multiple sclerosis publication-title: Brain doi: 10.1093/brain/awm329 – volume: 82 start-page: 1125 year: 2011 article-title: One year activity on subtraction MRI predicts subsequent 4 year activity and progression in multiple sclerosis publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.2011.242115 – volume: 13 start-page: 25 year: 2017 article-title: Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2016.187 – ident: 2020050722344376000_90.6.629.35 doi: 10.1212/WNL.0b013e3181f0734c – volume: 26 start-page: 184 year: 2016 ident: 2020050722344376000_90.6.629.16 article-title: The effect of fingolimod on conversion of acute gadolinium-enhancing lesions to chronic T1 hypointensities in multiple sclerosis publication-title: J Neuroimaging doi: 10.1111/jon.12307 – volume: 34 start-page: 21 year: 2013 ident: 2020050722344376000_90.6.629.26 article-title: The T-cell immunoglobulin and mucin domain (Tim) gene family in asthma, allergy, and autoimmunity publication-title: Allergy Asthma Proc doi: 10.2500/aap.2013.34.3646 – ident: 2020050722344376000_90.6.629.32 doi: 10.1093/brain/awm329 – ident: 2020050722344376000_90.6.629.15 doi: 10.1136/jnnp.2011.242115 – ident: 2020050722344376000_90.6.629.29 doi: 10.1038/nature10554 – ident: 2020050722344376000_90.6.629.13 doi: 10.1212/01.WNL.0000156155.19270.F8 – volume: 14 start-page: 199 year: 2017 ident: 2020050722344376000_90.6.629.30 article-title: Lipopolysaccharide binding protein and oxidative stress in a multiple sclerosis model publication-title: Neurotherapeutics doi: 10.1007/s13311-016-0480-0 – volume: 117 start-page: 15 year: 2008 ident: 2020050722344376000_90.6.629.8 article-title: Allergy, family history of autoimmune diseases, and the risk of multiple sclerosis publication-title: Acta Neurol Scand – ident: 2020050722344376000_90.6.629.14 doi: 10.3174/ajnr.A0795 – ident: 2020050722344376000_90.6.629.18 doi: 10.1111/apt.12984 – ident: 2020050722344376000_90.6.629.33 doi: 10.1056/NEJMoa011341 – ident: 2020050722344376000_90.6.629.24 doi: 10.1038/nature13835 – ident: 2020050722344376000_90.6.629.12 doi: 10.1002/ana.22366 – volume: 148 start-page: 209 year: 2013 ident: 2020050722344376000_90.6.629.31 article-title: Low sensitivity to glucocorticoid inhibition of in vitro Th17-related cytokine production in multiple sclerosis patients is related to elevated plasma lipopolysaccharide levels publication-title: Clin Immunol doi: 10.1016/j.clim.2013.05.012 – ident: 2020050722344376000_90.6.629.25 doi: 10.1038/nature12199 – ident: 2020050722344376000_90.6.629.21 doi: 10.1093/glycob/cwi053 – ident: 2020050722344376000_90.6.629.27 doi: 10.1007/s11910-014-0492-2 – ident: 2020050722344376000_90.6.629.4 doi: 10.1191/1352458504ms1087oa – volume: 74 start-page: 275 year: 2017 ident: 2020050722344376000_90.6.629.17 article-title: Association between serum MicroRNAs and magnetic resonance imaging measures of multiple sclerosis severity publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2016.5197 – ident: 2020050722344376000_90.6.629.11 doi: 10.1016/j.autrev.2006.02.012 – volume: 16 start-page: 751 year: 2016 ident: 2020050722344376000_90.6.629.23 article-title: Food allergy: immune mechanisms, diagnosis and immunotherapy publication-title: Nat Rev Immunol doi: 10.1038/nri.2016.111 – volume: 12 start-page: 182 year: 2013 ident: 2020050722344376000_90.6.629.5 article-title: The relation of multiple sclerosis with allergy and atopy: a case control study publication-title: Iran J Allergy Asthma Immunol – ident: 2020050722344376000_90.6.629.2 doi: 10.1038/nrneurol.2016.187 – volume: 248 start-page: 239 year: 2001 ident: 2020050722344376000_90.6.629.3 article-title: Prevalence of atopy in multiple sclerosis patients: a case-control study publication-title: J Neurol – ident: 2020050722344376000_90.6.629.28 doi: 10.1038/ncomms12015 – volume: 37 start-page: 369 year: 2017 ident: 2020050722344376000_90.6.629.37 article-title: Biologic therapies for immunoglobulin E-mediated food allergy and eosinophilic esophagitis publication-title: Immunol Allergy Clin North Am doi: 10.1016/j.iac.2017.01.010 – ident: 2020050722344376000_90.6.629.22 doi: 10.1016/j.cell.2014.12.020 – volume: 72 start-page: 1006 year: 2017 ident: 2020050722344376000_90.6.629.19 article-title: Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology publication-title: Allergy doi: 10.1111/all.13132 – volume: 123 start-page: 1 year: 2011 ident: 2020050722344376000_90.6.629.9 article-title: Association between allergies and multiple sclerosis: a systematic review and meta-analysis publication-title: Acta Neurol Scand doi: 10.1111/j.1600-0404.2010.01355.x – ident: 2020050722344376000_90.6.629.6 doi: 10.1177/1352458509106211 – ident: 2020050722344376000_90.6.629.7 doi: 10.1111/j.1365-2249.2006.03235.x – volume: 30 start-page: 36 year: 2017 ident: 2020050722344376000_90.6.629.36 article-title: Oral immunotherapy for food allergy publication-title: Semin Immunol doi: 10.1016/j.smim.2017.08.008 – ident: 2020050722344376000_90.6.629.1 doi: 10.1097/WCO.0b013e32815610c2 – ident: 2020050722344376000_90.6.629.34 doi: 10.1002/ana.23758 – volume: 375 start-page: 371 year: 2017 ident: 2020050722344376000_90.6.629.10 article-title: Evaluating the association of allergies with multiple sclerosis susceptibility risk and disease activity in a pediatric population publication-title: J Neurol Sci doi: 10.1016/j.jns.2017.02.041 – ident: 2020050722344376000_90.6.629.20 doi: 10.1186/1743-7075-6-22 – reference: 30630959 - J Neurol Neurosurg Psychiatry. 2019 Jun;90(6):625
SSID	ssj0000089
Score	2.3356402
Snippet	ObjectiveThe association between allergy and multiple sclerosis (MS) is still unclear. In our study, we assessed the association between a self-reported... The association between allergy and multiple sclerosis (MS) is still unclear. In our study, we assessed the association between a self-reported history of...
SourceID	proquest pubmed crossref bmj
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	629
SubjectTerms	Anaphylaxis Asthma Brain - diagnostic imaging Comorbidity Female Food allergies Food Hypersensitivity - complications Health risk assessment Humans Immune system Immunoglobulins Immunology Immunotherapy Longitudinal Studies Magnetic Resonance Imaging Male Middle Aged Multiple sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - etiology Neuroimaging Patients Questionnaires Severity of Illness Index Studies Surveys and Questionnaires
Title	Food allergies are associated with increased disease activity in multiple sclerosis
URI	https://jnnp.bmj.com/content/90/6/629.full https://www.ncbi.nlm.nih.gov/pubmed/30563943 https://www.proquest.com/docview/2226349902 https://www.proquest.com/docview/2158558599
Volume	90
WOSCitedRecordID	wos000471118100004&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Health & Medical Collection (ProQuest) customDbUrl: eissn: 1468-330X dateEnd: 20250607 omitProxy: false ssIdentifier: ssj0000089 issn: 0022-3050 databaseCode: 7X7 dateStart: 19440701 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1468-330X dateEnd: 20250607 omitProxy: false ssIdentifier: ssj0000089 issn: 0022-3050 databaseCode: 7RV dateStart: 19440701 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1468-330X dateEnd: 20250607 omitProxy: false ssIdentifier: ssj0000089 issn: 0022-3050 databaseCode: BENPR dateStart: 19440701 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database customDbUrl: eissn: 1468-330X dateEnd: 20250607 omitProxy: false ssIdentifier: ssj0000089 issn: 0022-3050 databaseCode: M2M dateStart: 19440701 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database (Proquest) customDbUrl: eissn: 1468-330X dateEnd: 20250607 omitProxy: false ssIdentifier: ssj0000089 issn: 0022-3050 databaseCode: M2P dateStart: 19440701 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9swDCbWdhh6Wfdutq7QgF52MBJbsiydhq1osEuCoHsgN0MvAyk6O4vT_f6Rtpxth7WHAoYAQdbDIiWSoswP4EzmvkK9VSVOe4sGiheJFsElobLWiKoS3NkObKKYz9VyqRfxwK2N1yqHPbHbqH3j6Ix8jHJMclTPJ9mH9c-EUKPIuxohNPbgICXZjfxcXH7_S_1VehctfJJPBjcll-Orul4jh6R0OKg5QcLs2R9X_wqn_2icneSZHt13zE_gcdQ52ceeSZ7Cg1A_g0ez6FV_Dl-mTeMZgapsKGgEM5vATCRb8IyOatmqJvWyxWx06TD6I4KAJ7CIDdcSWYsd4Ket2hfwbXrx9fxzEsEWEssl3yYK97k85CagiiKM04qjfEu9qopJnnnJrfGVKAK5aXE6jayM9JlOM-Od74LWvYT9uqnDMbBUZMZWvFBpCEKgfeeDst4rabMgK-9GcIZzXa77cBplZ4ZwWRJJSiJJ2ZNkBOOBGKWLAcsJN-P6lhrvdzXubv1koFkZl21b_iHYCN7tinHBkRfF1KG5wXdStLDw0XoEr3q-2HVG9hjXgr--vfE3cIgj0f2NsxPY325uwlt46H5tV-3mtONhSpdFl6pTOPh0MV9cYm6Wzbp08RtVFf24
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB61BUEvPEu7pYCRyoFDtJvYceIDQghYtWq7QqJIewt-SltBst1sQfwpfmNn8ljgQDn1gJRLlNhO4s_z8EzmA9iXqQtot-aRVc6gg-JEpIS3kQ_GaBGC4NY0ZBPZZJJPp-rDGvzs_4WhtMpeJjaC2lWW9siHqMckR_N8lLyen0fEGkXR1Z5Co4XFkf_xHV22-tXhO5zfF0kyfn_69iDqWAUiwyVfRjku6NSn2qMuFtqqnKMgj10eslGaOMmNdkFknuKRqN-0DFq6RMWJdtY11dmw33W4gXI8oxSybJr9Zm7nalWdfJSO-rAol8OzspwjImPajFScKGjWzdezP5XhXyzcRtON7_5v3-ge3OlsavamXQT3Yc2XD-DWSZc18BA-jqvKMSKNWVBRDKYXnukOlt4x2opms5LM5xpPu5AVoz8-iFgDL7E-7ZLVOAB-ylm9BZ-u5ZUewUZZlX4HWCwSbQLP8th7IdB_dT43zuXSJF4GZwewj3NbzNtyIUXjZnFZEAQKgkDRQmAAw37yC9sVZCdekC9XtHi5avHv3vd6jBSdWKqLXwAZwPPVZRQoFCXSpa8u8J4YPUg8lBrAdovD1WDkb3Il-O7VnT-D2wenJ8fF8eHk6DFs4lOpNrtuDzaWiwv_BG7ab8tZvXjarB8Gn68bjJckoFT4
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB61BVVceD8WChipHDhEu4kdxz4ghCgrqtLVSoDUW_BT2gqSZbMF8df4dczkscCBcuoBKZfIsZ3Y37w8kxmAfZn7iHqrSpz2Fg0ULxItgktCtNaIGAV3ti02Ucxm6uREz7fgx_AvDIVVDjyxZdS-dnRGPkY5Jjmq55NsHPuwiPnB9MXyS0IVpMjTOpTT6CByFL5_Q_OteX54gHv9NMumr9-_epP0FQYSyyVfJwqJOw-5CSiXhXFacWTqqVexmOSZl9waH0URyDeJss7IaKTPdJoZ73ybqQ3H3YZLhchzoq7jbP6b6q30JlP5JJ8MLlIux6dVtUR0pnQwqTmVo9m2n0__FIx_0XZbqTe99j-v13W42uva7GVHHDdgK1Q3Yfe4jya4Be-mde0ZFZNZUbIMZlaBmR6uwTM6omaLitTqBm97VxajP0Go4AY2sSEckzU4AS7rorkNHy7kk-7ATlVX4R6wVGTGRl6oNAQh0K71QVnvlbRZkNG7EezjPpfLLo1I2ZpfXJYEh5LgUHZwGMF4AELp-kTtVC_k0zk9nm16_Hv0vQEvZc-umvIXWEbwZNOMjIa8R6YK9Rk-k6JliZfWI7jbYXIzGdmhXAt-__zBH8MuYrB8ezg7egBX8KV0F3S3Bzvr1Vl4CJfd1_WiWT1qSYnBx4vG4k-6h13F
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Food+allergies+are+associated+with+increased+disease+activity+in+multiple+sclerosis&rft.jtitle=Journal+of+neurology%2C+neurosurgery+and+psychiatry&rft.au=Fakih%2C+Rami&rft.au=Diaz-Cruz%2C+Camilo&rft.au=Chua%2C+Alicia+S&rft.au=Gonzalez%2C+Cindy&rft.date=2019-06-01&rft.pub=BMJ+Publishing+Group+LTD&rft.issn=0022-3050&rft.eissn=1468-330X&rft.volume=90&rft.issue=6&rft.spage=629&rft_id=info:doi/10.1136%2Fjnnp-2018-319301&rft.externalDBID=HAS_PDF_LINK
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3050&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3050&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3050&client=summon