Global epidemiology of acromegaly: a systematic review and meta-analysis

To date, no systematic reviews and meta-analysis on the global epidemiology of acromegaly are available in the literature. The aims of this study are to provide a systematic review and a meta-analysis of the global epidemiology of acromegaly and to evaluate the quality of study reporting for the ide...

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Veröffentlicht in:	European journal of endocrinology Jg. 185; H. 2; S. 251
Hauptverfasser:	Crisafulli, Salvatore, Luxi, Nicoletta, Sultana, Janet, Fontana, Andrea, Spagnolo, Federica, Giuffrida, Giuseppe, Ferraù, Francesco, Gianfrilli, Daniele, Cozzolino, Alessia, Cristina De Martino, Maria, Gatto, Federico, Barone-Adesi, Francesco, Cannavò, Salvatore, Trifirò, Gianluca
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.08.2021
Schlagworte:	Acromegaly - epidemiology Data Accuracy Epidemiologic Research Design Geography Global Health - statistics & numerical data Humans Observational Studies as Topic - standards Observational Studies as Topic - statistics & numerical data
ISSN:	1479-683X, 1479-683X
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Abstract	To date, no systematic reviews and meta-analysis on the global epidemiology of acromegaly are available in the literature. The aims of this study are to provide a systematic review and a meta-analysis of the global epidemiology of acromegaly and to evaluate the quality of study reporting for the identified studies. MEDLINE, EMBASE and The Cochrane Library databases were searched for studies assessing the epidemiology of acromegaly from inception until 31 January 2020. We included original observational studies written in English, reporting acromegaly prevalence and/or incidence for a well-defined geographic area. Two reviewers independently extracted data and performed quality assessments. Prevalence and incidence pooled estimates were derived by performing a random-effects meta-analysis. A total of 32 studies were included in the systematic review, and 22 of them were included in the meta-analysis. The pooled prevalence of acromegaly was 5.9 (95% CI: 4.4-7.9) per 100 000 persons, while the incidence rate (IR) was 0.38 (95% CI: 0.32-0.44) cases per 100 000 person-years. For both prevalence and IR, considerable between-study heterogeneity was found (I2 = 99.3 and 86.0%, respectively). The quality of study reporting was rated as the medium for 20 studies and low for 12 studies. Although the largest amount of heterogeneity was due to the high precision of the studies' estimates, data source and geographic area could represent relevant study-level factors which could explain about 50% of the total between-study variability. Large-scale high-quality studies on the epidemiology of acromegaly are warranted to help the public health system in making decisions.
AbstractList	To date, no systematic reviews and meta-analysis on the global epidemiology of acromegaly are available in the literature. The aims of this study are to provide a systematic review and a meta-analysis of the global epidemiology of acromegaly and to evaluate the quality of study reporting for the identified studies.OBJECTIVETo date, no systematic reviews and meta-analysis on the global epidemiology of acromegaly are available in the literature. The aims of this study are to provide a systematic review and a meta-analysis of the global epidemiology of acromegaly and to evaluate the quality of study reporting for the identified studies.MEDLINE, EMBASE and The Cochrane Library databases were searched for studies assessing the epidemiology of acromegaly from inception until 31 January 2020. We included original observational studies written in English, reporting acromegaly prevalence and/or incidence for a well-defined geographic area. Two reviewers independently extracted data and performed quality assessments. Prevalence and incidence pooled estimates were derived by performing a random-effects meta-analysis.METHODSMEDLINE, EMBASE and The Cochrane Library databases were searched for studies assessing the epidemiology of acromegaly from inception until 31 January 2020. We included original observational studies written in English, reporting acromegaly prevalence and/or incidence for a well-defined geographic area. Two reviewers independently extracted data and performed quality assessments. Prevalence and incidence pooled estimates were derived by performing a random-effects meta-analysis.A total of 32 studies were included in the systematic review, and 22 of them were included in the meta-analysis. The pooled prevalence of acromegaly was 5.9 (95% CI: 4.4-7.9) per 100 000 persons, while the incidence rate (IR) was 0.38 (95% CI: 0.32-0.44) cases per 100 000 person-years. For both prevalence and IR, considerable between-study heterogeneity was found (I2 = 99.3 and 86.0%, respectively). The quality of study reporting was rated as the medium for 20 studies and low for 12 studies.RESULTSA total of 32 studies were included in the systematic review, and 22 of them were included in the meta-analysis. The pooled prevalence of acromegaly was 5.9 (95% CI: 4.4-7.9) per 100 000 persons, while the incidence rate (IR) was 0.38 (95% CI: 0.32-0.44) cases per 100 000 person-years. For both prevalence and IR, considerable between-study heterogeneity was found (I2 = 99.3 and 86.0%, respectively). The quality of study reporting was rated as the medium for 20 studies and low for 12 studies.Although the largest amount of heterogeneity was due to the high precision of the studies' estimates, data source and geographic area could represent relevant study-level factors which could explain about 50% of the total between-study variability. Large-scale high-quality studies on the epidemiology of acromegaly are warranted to help the public health system in making decisions.CONCLUSIONSAlthough the largest amount of heterogeneity was due to the high precision of the studies' estimates, data source and geographic area could represent relevant study-level factors which could explain about 50% of the total between-study variability. Large-scale high-quality studies on the epidemiology of acromegaly are warranted to help the public health system in making decisions. To date, no systematic reviews and meta-analysis on the global epidemiology of acromegaly are available in the literature. The aims of this study are to provide a systematic review and a meta-analysis of the global epidemiology of acromegaly and to evaluate the quality of study reporting for the identified studies. MEDLINE, EMBASE and The Cochrane Library databases were searched for studies assessing the epidemiology of acromegaly from inception until 31 January 2020. We included original observational studies written in English, reporting acromegaly prevalence and/or incidence for a well-defined geographic area. Two reviewers independently extracted data and performed quality assessments. Prevalence and incidence pooled estimates were derived by performing a random-effects meta-analysis. A total of 32 studies were included in the systematic review, and 22 of them were included in the meta-analysis. The pooled prevalence of acromegaly was 5.9 (95% CI: 4.4-7.9) per 100 000 persons, while the incidence rate (IR) was 0.38 (95% CI: 0.32-0.44) cases per 100 000 person-years. For both prevalence and IR, considerable between-study heterogeneity was found (I2 = 99.3 and 86.0%, respectively). The quality of study reporting was rated as the medium for 20 studies and low for 12 studies. Although the largest amount of heterogeneity was due to the high precision of the studies' estimates, data source and geographic area could represent relevant study-level factors which could explain about 50% of the total between-study variability. Large-scale high-quality studies on the epidemiology of acromegaly are warranted to help the public health system in making decisions.
Author	Cannavò, Salvatore Cristina De Martino, Maria Gatto, Federico Gianfrilli, Daniele Fontana, Andrea Ferraù, Francesco Sultana, Janet Spagnolo, Federica Crisafulli, Salvatore Barone-Adesi, Francesco Trifirò, Gianluca Giuffrida, Giuseppe Luxi, Nicoletta Cozzolino, Alessia
Author_xml	– sequence: 1 givenname: Salvatore surname: Crisafulli fullname: Crisafulli, Salvatore organization: Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy – sequence: 2 givenname: Nicoletta surname: Luxi fullname: Luxi, Nicoletta organization: Department of Diagnostics and Public Health, University of Verona, Verona, Italy – sequence: 3 givenname: Janet surname: Sultana fullname: Sultana, Janet organization: College of Medicine and Health, University of Exeter, UK – sequence: 4 givenname: Andrea surname: Fontana fullname: Fontana, Andrea organization: Unit of Biostatistics, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy – sequence: 5 givenname: Federica surname: Spagnolo fullname: Spagnolo, Federica organization: Endocrine Unit, University Hospital "G. Martino", Messina, Italy – sequence: 6 givenname: Giuseppe surname: Giuffrida fullname: Giuffrida, Giuseppe organization: Endocrine Unit, University Hospital "G. Martino", Messina, Italy – sequence: 7 givenname: Francesco surname: Ferraù fullname: Ferraù, Francesco organization: Endocrine Unit, University Hospital "G. Martino", Messina, Italy – sequence: 8 givenname: Daniele surname: Gianfrilli fullname: Gianfrilli, Daniele organization: Section of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome – sequence: 9 givenname: Alessia surname: Cozzolino fullname: Cozzolino, Alessia organization: Section of Medical Pathophysiology and Endocrinology, Department of Experimental Medicine, Sapienza University of Rome, Rome – sequence: 10 givenname: Maria surname: Cristina De Martino fullname: Cristina De Martino, Maria organization: Department of Clinical Medicine and Surgery, Section of Endocrinology, Università Federico II di Napoli, Naples, Italy – sequence: 11 givenname: Federico surname: Gatto fullname: Gatto, Federico organization: Endocrinology Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy – sequence: 12 givenname: Francesco surname: Barone-Adesi fullname: Barone-Adesi, Francesco organization: Research Center in Emergency and Disaster Medicine (CRIMEDIM), University Piemonte Orientale, Novara, Italy – sequence: 13 givenname: Salvatore surname: Cannavò fullname: Cannavò, Salvatore organization: Endocrine Unit, University Hospital "G. Martino", Messina, Italy – sequence: 14 givenname: Gianluca surname: Trifirò fullname: Trifirò, Gianluca organization: Department of Diagnostics and Public Health, University of Verona, Verona, Italy
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Snippet	To date, no systematic reviews and meta-analysis on the global epidemiology of acromegaly are available in the literature. The aims of this study are to...
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SubjectTerms	Acromegaly - epidemiology Data Accuracy Epidemiologic Research Design Geography Global Health - statistics & numerical data Humans Observational Studies as Topic - standards Observational Studies as Topic - statistics & numerical data
Title	Global epidemiology of acromegaly: a systematic review and meta-analysis
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