Patent Survey of Resveratrol, Taxol, Podophyllotoxin, Withanolides and Their Derivatives Used in Anticancer Therapy

Resveratrol, taxol, podophyllotoxin, withanolides and their derivatives find applications in anti-cancer therapy. They are plant-derived compounds whose chemical structures and synthesis limit their natural availability and restrict a large-scale industrial production. Hence, their production by var...

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Veröffentlicht in:Recent patents on biotechnology Jg. 11; H. 2; S. 85
Hauptverfasser: Routh, Shreya, Nandagopal, Krishnadas
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United Arab Emirates 2017
Schlagworte:
Humans
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Paclitaxel - therapeutic use
Patents as Topic
Podophyllotoxin - therapeutic use
Stilbenes - therapeutic use
Withanolides - therapeutic use
Patents
podophyllotoxin
patent databases
patent search strategies
taxol
plant-derived anti-cancer agents
withanolides
resveratrol
ISSN:2212-4012, 2212-4012
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Zusammenfassung:Resveratrol, taxol, podophyllotoxin, withanolides and their derivatives find applications in anti-cancer therapy. They are plant-derived compounds whose chemical structures and synthesis limit their natural availability and restrict a large-scale industrial production. Hence, their production by various biotechnological approaches may hold promise for a continuous and reliable mode of supply. We review process and product patents in this regard. Accordingly, we provide a general outline to search the freely accessible WIPO, EPO, USPTO and Cambia databases with several keywords and patent codes. We have tabulated both granted and filed patents from the said databases. We retrieved ~40 patents from these databases. Novel biotechnological processes for production of these anticancer compounds include Agrobacterium rhizogenes-mediated hairy root culture, suspension culture, cell culture with elicitors, use of recombinant microorganisms, and bioreactors among others. The results are indicative of being both database-specific as well as queryspecific. A ten-year search window yielded 33 patents. The utility of the search strategy is discussed in the light of biotechnological developments in the field. Those who examine patent literature using similar search strategies may complement their knowledge obtained from perusal of mainstream journal resources.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:2212-4012
2212-4012
DOI:10.2174/1872208311666170127114804