Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

The human Red Hair Color (RHC) trait is caused by increased pheomelanin (red-yellow) and reduced eumelanin (black-brown) pigment in skin and hair due to diminished melanocortin 1 receptor (MC1R) function. In addition, individuals harboring the RHC trait are predisposed to melanoma development. While...

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Bibliographic Details
Published in:	bioRxiv
Main Authors:	Berns, H Matthew, Watkins-Chow, Dawn E, Lu, Sizhu, Louphrasitthiphol, Pakavarin, Zhang, Tongwu, Brown, Kevin M, Moura-Alves, Pedro, Goding, Colin R, Pavan, William J
Format:	Journal Article Paper
Language:	English
Published:	United States Cold Spring Harbor Laboratory Press 13.03.2023 Cold Spring Harbor Laboratory
Edition:	1.2
Subjects:	Animal models Genetics Hair Melanocortin Melanocyte-stimulating hormone Melanocytes Melanoma Phenotypes Pheomelanin Pigmentation Risk factors Senescence melanoma melanocortin 1 receptor (MC1R) melanocytes red hair color TBX3
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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