K2PdCl4/PPh3-catalyzed Carbon-sulfur Coupling Reaction; An Efficient and One-pot Method to Direct Synthesis of Organic Disulfides/Sulfides from Aryl Halides and Thiourea

This work describes an efficient and new catalyst for the one-pot synthesis of organic disulfides/sulfides via a palladium catalyst in the presence of PPh3 ligands for domino cross-coupling reaction of aryl halides and thiourea and then sulfur-transformation. Finally, the generated aryl thiolate con...

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Veröffentlicht in:Letters in organic chemistry Jg. 15; H. 11; S. 899 - 904
Hauptverfasser: Raeisi, Masoumeh, Mohammadi, Fariba, Soleiman-Beigi, Mohammad, Naghipour, Ali
Format: Journal Article
Sprache:Englisch
Veröffentlicht: SHARJAH Bentham Science Publ Ltd 01.01.2018
Schlagworte:
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
cross-coupling reaction
thiourea
Palladium catalyst
CATALYZED SYNTHESIS
organic disulfides/sulfides
K2PdCl4
halides
DISULFIDE
ISSN:1570-1786, 1875-6255
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Beschreibung
Zusammenfassung:This work describes an efficient and new catalyst for the one-pot synthesis of organic disulfides/sulfides via a palladium catalyst in the presence of PPh3 ligands for domino cross-coupling reaction of aryl halides and thiourea and then sulfur-transformation. Finally, the generated aryl thiolate converts to disulfide at normal oxidative and atmospheric conditions in DMF/water. However, thiols convert to unsymmetrical sulfides by one-pot reaction with alkyl halides in PEG/H2O.
ISSN:1570-1786
1875-6255
DOI:10.2174/1570178615666180412122502