Theme Issue Honoring Prof. Dr. Ludger Wessjohann's 60th Birthday: Natural Products in Modern Drug Discovery

Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, na...

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Format: E-Book
Sprache:Englisch
Veröffentlicht: Basel MDPI - Multidisciplinary Digital Publishing Institute 2022
Schlagworte:
ampullosporin
angiogenesis
anti-tumor peptides
antibody engineering
anticancer
anticancer activity
antifungal
antiproliferative
apoptosis
apoptosis resistance
ATG 4B
biorthogonal chemistry
bispecific antibody
botanical agents
breast cancer
butein
cancer stem cells
cancer treatment
caspase-3
Chemistry
click chemistry
co-culture
coronavirus
Cosmospora sp
COX inhibitory
cytotoxic
cytotoxic activity
DARTS
Decachaeta incompta
demissidine
docking
drug resistance
ECD-TDDFT
electron paramagnetic resonance (EPR) spectroscopy
flavonoids
frondoside-A
fusidic acid
glutamic acid methyl ester
hepatocellular carcinoma
in vitro model
incomptine A
invasion
iTRAQ
kaempferol
lung cancer
Magnaporthe oryzae
marine fungi
Mathematics and Science
medicinal herbs
melanoma
MERS-CoV
metabolomics
metastasis
molecular docking
molecular networking
multi-component reaction
n/a
natural products
ophiobolin A
Organic chemistry
PCD
peptaibols
phytochemicals
phytopathogen
polygodial
pregnancy
proliferation
RCE-4
Reference, Information and Interdisciplinary subjects
Research and information: general
ROS production
SARS-CoV
SARS-CoV-2
Sepedonium ampullosporum
sesquiterpene lactone
solanidane alkaloids
solanidine
solid-phase peptide synthesis
soudanone
Sparticola junci
Src
STAT3
stemness
steroidal alkaloids
structure elucidation
target identification
TEMPO-conjugate
the Bcl-2–Beclin 1 complex
Trypsiligase
tumor growth
tumor heterogeneity
tumor microenvironment (TME)
viability
violacein
Wittig reaction
ISBN:9783036547435, 9783036547442, 3036547436, 3036547444
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, natural products feature pharmacologically active pharmacophores which are pharmaceutically validated starting points for the development of new lead compounds. Over half of all approved (from 1981 to 2014) small-molecule drugs derived from NPs, including unaltered NPs, NPs synthetic derivatives and synthetic natural mimics, originated from a NPs pharmacophore or template. According to the FDA, NPs and their derivatives represent over one-third of all FDA-approved new drugs, in particular for anticancer/antibiotic lead compounds, which are remarkably enriched with NPs.
ISBN:9783036547435
9783036547442
3036547436
3036547444
DOI:10.3390/books978-3-0365-4743-5