NKp30 and NKG2D contribute to natural killer recognition of HIV-infected cells
Natural killer (NK) cells respond rapidly in early HIV-1 infection. HIV-1 prevention and control strategies harnessing NK cells could be enabled by mechanistic understanding of how NK cells recognize HIV-infected T cells. Here, we profiled the phenotype of human primary NK cells responsive to autolo...
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United States
Cold Spring Harbor Laboratory
27.06.2024
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| Vydání: | 1.1 |
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| ISSN: | 2692-8205, 2692-8205 |
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| Abstract | Natural killer (NK) cells respond rapidly in early HIV-1 infection. HIV-1 prevention and control strategies harnessing NK cells could be enabled by mechanistic understanding of how NK cells recognize HIV-infected T cells. Here, we profiled the phenotype of human primary NK cells responsive to autologous HIV-1-infected CD4
T cells in vitro. We characterized the patterns of NK cell ligand expression on CD4
T cells at baseline and after infection with a panel of transmitted/founder HIV-1 strains to identify key receptor-ligand pairings. CRISPR editing of CD4
T cells to knockout the NKp30 ligand B7-H6, or the NKG2D ligands MICB or ULBP2 reduced NK cell responses to HIV-infected cells in some donors. In contrast, overexpression of NKp30 or NKG2D in NK cells enhanced their targeting of HIV-infected cells. Collectively, we identified receptor-ligand pairs including NKp30:B7-H6 and NKG2D:MICB/ULBP2 that contribute to NK cell recognition of HIV-infected cells. |
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| AbstractList | Natural killer (NK) cells respond rapidly in early HIV-1 infection. HIV-1 prevention and control strategies harnessing NK cells could be enabled by mechanistic understanding of how NK cells recognize HIV-infected T cells. Here, we profiled the phenotype of human primary NK cells responsive to autologous HIV-1-infected CD4
+
T cells in vitro. We characterized the patterns of NK cell ligand expression on CD4
+
T cells at baseline and after infection with a panel of transmitted/founder HIV-1 strains to identify key receptor-ligand pairings. CRISPR editing of CD4
+
T cells to knockout the NKp30 ligand B7-H6, or the NKG2D ligands MICB or ULBP2 reduced NK cell responses to HIV-infected cells in some donors. In contrast, overexpression of NKp30 or NKG2D in NK cells enhanced their targeting of HIV-infected cells. Collectively, we identified receptor-ligand pairs including NKp30:B7-H6 and NKG2D:MICB/ULBP2 that contribute to NK cell recognition of HIV-infected cells. Natural killer (NK) cells respond rapidly in early HIV-1 infection. HIV-1 prevention and control strategies harnessing NK cells could be enabled by mechanistic understanding of how NK cells recognize HIV-infected T cells. Here, we profiled the phenotype of human primary NK cells responsive to autologous HIV-1-infected CD4 T cells in vitro. We characterized the patterns of NK cell ligand expression on CD4 T cells at baseline and after infection with a panel of transmitted/founder HIV-1 strains to identify key receptor-ligand pairings. CRISPR editing of CD4 T cells to knockout the NKp30 ligand B7-H6, or the NKG2D ligands MICB or ULBP2 reduced NK cell responses to HIV-infected cells in some donors. In contrast, overexpression of NKp30 or NKG2D in NK cells enhanced their targeting of HIV-infected cells. Collectively, we identified receptor-ligand pairs including NKp30:B7-H6 and NKG2D:MICB/ULBP2 that contribute to NK cell recognition of HIV-infected cells. Natural killer (NK) cells respond rapidly in early HIV-1 infection. HIV-1 prevention and control strategies harnessing NK cells could be enabled by mechanistic understanding of how NK cells recognize HIV-infected T cells. Here, we profiled the phenotype of human primary NK cells responsive to autologous HIV-1-infected CD4+ T cells in vitro. We characterized the patterns of NK cell ligand expression on CD4+ T cells at baseline and after infection with a panel of transmitted/founder HIV-1 strains to identify key receptor-ligand pairings. CRISPR editing of CD4+ T cells to knockout the NKp30 ligand B7-H6, or the NKG2D ligands MICB or ULBP2 reduced NK cell responses to HIV-infected cells in some donors. In contrast, overexpression of NKp30 or NKG2D in NK cells enhanced their targeting of HIV-infected cells. Collectively, we identified receptor-ligand pairs including NKp30:B7-H6 and NKG2D:MICB/ULBP2 that contribute to NK cell recognition of HIV-infected cells. Natural killer (NK) cells respond rapidly in early HIV-1 infection. HIV-1 prevention and control strategies harnessing NK cells could be enabled by mechanistic understanding of how NK cells recognize HIV-infected T cells. Here, we profiled the phenotype of human primary NK cells responsive to autologous HIV-1-infected CD4 + T cells in vitro. We characterized the patterns of NK cell ligand expression on CD4 + T cells at baseline and after infection with a panel of transmitted/founder HIV-1 strains to identify key receptor-ligand pairings. CRISPR editing of CD4 + T cells to knockout the NKp30 ligand B7-H6, or the NKG2D ligands MICB or ULBP2 reduced NK cell responses to HIV-infected cells in some donors. In contrast, overexpression of NKp30 or NKG2D in NK cells enhanced their targeting of HIV-infected cells. Collectively, we identified receptor-ligand pairs including NKp30:B7-H6 and NKG2D:MICB/ULBP2 that contribute to NK cell recognition of HIV-infected cells.Natural killer (NK) cells respond rapidly in early HIV-1 infection. HIV-1 prevention and control strategies harnessing NK cells could be enabled by mechanistic understanding of how NK cells recognize HIV-infected T cells. Here, we profiled the phenotype of human primary NK cells responsive to autologous HIV-1-infected CD4 + T cells in vitro. We characterized the patterns of NK cell ligand expression on CD4 + T cells at baseline and after infection with a panel of transmitted/founder HIV-1 strains to identify key receptor-ligand pairings. CRISPR editing of CD4 + T cells to knockout the NKp30 ligand B7-H6, or the NKG2D ligands MICB or ULBP2 reduced NK cell responses to HIV-infected cells in some donors. In contrast, overexpression of NKp30 or NKG2D in NK cells enhanced their targeting of HIV-infected cells. Collectively, we identified receptor-ligand pairs including NKp30:B7-H6 and NKG2D:MICB/ULBP2 that contribute to NK cell recognition of HIV-infected cells. |
| Author | Pi, Ruoxi Nguyen, David N Marson, Alexander Seiler, Christof Blish, Catherine A Holmes, Susan Ranganath, Thanmayi Zhao, Nancy Q |
| Author_xml | – sequence: 1 givenname: Nancy Q surname: Zhao fullname: Zhao, Nancy Q – sequence: 2 givenname: Ruoxi orcidid: 0000-0002-2491-0979 surname: Pi fullname: Pi, Ruoxi – sequence: 3 givenname: David N surname: Nguyen fullname: Nguyen, David N – sequence: 4 givenname: Thanmayi orcidid: 0000-0001-9865-2119 surname: Ranganath fullname: Ranganath, Thanmayi – sequence: 5 givenname: Christof orcidid: 0000-0001-8802-3642 surname: Seiler fullname: Seiler, Christof – sequence: 6 givenname: Susan surname: Holmes fullname: Holmes, Susan – sequence: 7 givenname: Alexander surname: Marson fullname: Marson, Alexander – sequence: 8 givenname: Catherine A surname: Blish fullname: Blish, Catherine A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38979175$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1097/QAD.0000000000002488 10.1172/JCI162694 10.1128/JVI.00719-19 10.1128/JVI.01185-19 10.1172/jci.insight.155601 10.3390/v9100295 |
| ContentType | Journal Article Paper |
| Copyright | 2024, Posted by Cold Spring Harbor Laboratory |
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| Keywords | NK cells HIV CART transfection CyTOF CRISPR editing |
| Language | English |
| License | This pre-print is available under a Creative Commons License (Attribution-NonCommercial-NoDerivs 4.0 International), CC BY-NC-ND 4.0, as described at http://creativecommons.org/licenses/by-nc-nd/4.0 |
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| Notes | ObjectType-Working Paper/Pre-Print-3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interest Statement: CAB is a scientific advisory board member of ImmuneBridge, DeepCell, Inc., and Qihan Bio on topics unrelated to this manuscript. A.M. is a cofounder of Site Tx, Arsenal Biosciences, Spotlight Therapeutics and Survey Genomics, serves on the boards of directors at Site Tx, Spotlight Therapeutics and Survey Genomics, is a member of the scientific advisory boards of Site Tx, Arsenal Biosciences, Spotlight Therapeutics, Survey Genomics, NewLimit, Amgen, and Tenaya, owns stock in Arsenal Biosciences, Site Tx, Spotlight Therapeutics, NewLimit, Survey Genomics, Tenaya and Lightcast and has received fees from Site Tx, Arsenal Biosciences, Spotlight Therapeutics, NewLimit, 23andMe, PACT Pharma, Juno Therapeutics, Tenaya, Lightcast, Trizell, Vertex, Merck, Amgen, Genentech, GLG, ClearView Healthcare, AlphaSights, Rupert Case Management, Bernstein and ALDA. A.M. is an investor in and informal advisor to Offline Ventures and a client of EPIQ. The Marson laboratory has received research support from the Parker Institute for Cancer Immunotherapy, the Emerson Collective, Juno Therapeutics, Epinomics, Sanofi, GlaxoSmithKline, Gilead and Anthem and reagents from Genscript and Illumina. |
| ORCID | 0000-0001-8802-3642 0000-0002-2491-0979 0000-0001-9865-2119 |
| OpenAccessLink | https://www.biorxiv.org/content/10.1101/2024.06.24.600449 |
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| PublicationDate | 2024-Jun-27 20240627 |
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| References | 41079618 - iScience. 2025 Sep 12;28(10):113548. doi: 10.1016/j.isci.2025.113548. Cerboni, Zingoni, Cippitelli, Piccoli, Frati, Santoni (2024.06.24.600449v1.49) 2007; 110 van Stigt Thans, Akko, Niehrs, Garcia-Beltran, Richert, Stürzel, Ford, Li, Ochsenbauer, Kappes (2024.06.24.600449v1.22) 2019; 93 Barrow, Martin, Colonna (2024.06.24.600449v1.46) 2019; 10 Sanchez-Correa, Gayoso, Bergua, Casado, Morgado, Solana, Tarazona (2024.06.24.600449v1.55) 2012; 90 Seiler, Ferreira, Kronstad, Simpson, Le Gars, Vendrame, Blish, Holmes (2024.06.24.600449v1.32) 2021; 22 Huot, Jacquelin, Garcia-Tellez, Rascle, Ploquin, Madec, Reeves, Derreudre-Bosquet, Müller-Trutwin (2024.06.24.600449v1.7) 2017; 23 Ravet, Scott-Algara, Bonnet, Tran, Tran, Nguyen, Truong, Theodorou, Barré-Sinoussi, Pancino (2024.06.24.600449v1.4) 2007; 109 Kronstad, Seiler, Vergara, Holmes, Blish (2024.06.24.600449v1.29) 2018; 201 Carlsten, Norell, Bryceson, Poschke, Schedvins, Ljunggren, Kiessling, Malmberg (2024.06.24.600449v1.54) 2009; 183 Kazer, Aicher, Muema, Carroll, Ordovas-Montanes, Miao, Tu, Ziegler, Nyquist, Wong (2024.06.24.600449v1.3) 2020; 26 Alter, Martin, Teigen, Carr, Suscovich, Schneidewind, Streeck, Waring, Meier, Brander (2024.06.24.600449v1.12) 2007; 204 Eissmann, Beauchamp, Wooters, Tilton, Long, Watzl (2024.06.24.600449v1.58) 2005; 105 Fogli, Mavilio, Brunetta, Varchetta, Ata, Roby, Kovacs, Follmann, Pende, Ward (2024.06.24.600449v1.43) 2008; 4 Richard, Sindhu, Pham, Belzile, Cohen (2024.06.24.600449v1.23) 2010; 115 Clayton, Mitchell, Court, Linnane, Mason, Tabi (2024.06.24.600449v1.50) 2008; 180 Vendrame, Seiler, Ranganath, Zhao, Vergara, Alary, Labbé, Guédou, Poudrier, Holmes (2024.06.24.600449v1.34) 2020 Romero-Martín, Duran-Castells, Olivella, Rosás-Umbert, Ruiz-Riol, Sanchez, Hartigan-O Connor, Mothe, Olvera, Brander (2024.06.24.600449v1.20) 2022; 13 Sungur, Wang, Ozantürk, Gao, Schmitz, Cella, Yokoyama, Shan (2024.06.24.600449v1.9) 2022; 132 Zingoni, Molfetta, Fionda, Soriani, Paolini, Cippitelli, Cerboni, Santoni (2024.06.24.600449v1.61) 2018; 9 Marchitto, Benlarbi, Prévost, Laumaea, Descôteaux-Dinelle, Medjahed, Bourassa, Gendron-Lepage, Kirchhoff, Sauter (2024.06.24.600449v1.26) 2023; 14 Ezinne, Yoshimitsu, White, Arima (2024.06.24.600449v1.56) 2014; 9 Kilian, Friedrich, Lu, Vonhören, Jansky, Michel, Keib, Stange, Hackert, Kehl (2024.06.24.600449v1.33) 2024; 9 Huot, Rascle, Petitdemange, Contreras, Stürzel, Baquero, Harper, Passaes, Legendre, Varet (2024.06.24.600449v1.62) 2021; 12 Galaski, Ahmad, Tibroni, Pujol, Müller, Schmidt, Fackler (2024.06.24.600449v1.24) 2016; 72 Chlewicki, Velikovsky, Balakrishnan, Mariuzza, Kumar (2024.06.24.600449v1.57) 2008; 180 Rahman, Billingsley, Sharma, Styles, Govindaraj, Shanmugasundaram, Babu, Riberio, Ali, Tharp (2024.06.24.600449v1.8) 2022; 7 Davis, Cogswell, Scott, Mertsching, Boucau, Wambua, Le Gall, Planelles, Campbell, Barker (2024.06.24.600449v1.19) 2016; 12 Poss, Overbaugh (2024.06.24.600449v1.31) 1999; 73 Spidlen, Breuer, Brinkman (2024.06.24.600449v1.68) 2012; 10 (2024.06.24.600449v1.71) 2018 Nowicka, Krieg, Crowell, Weber, Hartmann, Guglietta, Becher, Levesque, Robinson (2024.06.24.600449v1.72) 2017 Lucar, Sadjo Diallo, Bayard, Samri, Tarantino, Debré, Thiébaut, Brun-Vézinet, Matheron, Cheynier (2024.06.24.600449v1.45) 2019; 33 Ward, Bonaparte, Sacks, Guterman, Fogli, Mavilio, Barker (2024.06.24.600449v1.47) 2007; 110 Apps, Del Prete, Chatterjee, Lara, Brumme, Brockman, Neil, Pickering, Schneider, Piechocka-Trocha (2024.06.24.600449v1.14) 2016; 19 Horowitz, Strauss-Albee, Leipold, Kubo, Nemat-Gorgani, Dogan, Dekker, Mackey, Maecker, Swan (2024.06.24.600449v1.27) 2013; 5 Ziegler, Nelde, Weber, Schreitmüller, Martrus, Huynh, Bunders, Lunemann, Stevanovic, Zhou (2024.06.24.600449v1.63) 2020; 34 Cohen, Gandhi, Davis, Mandelboim, Chen, Strominger, Baltimore (2024.06.24.600449v1.15) 1999; 10 Overbaugh, Morris (2024.06.24.600449v1.64) 2012; 2 Li, Piampongsant, Faria, Voet, Pineda-Peña, Khouri, Lemey, Vandamme, Theys (2024.06.24.600449v1.66) 2015; 12 Bonaparte, Barker (2024.06.24.600449v1.42) 2003; 17 Shah, Sowrirajan, Davis, Ward, Campbell, Planelles, Barker (2024.06.24.600449v1.25) 2010; 8 Martin, Qi, Gao, Yamada, Martin, Pereyra, Colombo, Brown, Shupert, Phair (2024.06.24.600449v1.10) 2007; 39 Spidlen, Breuer, Rosenberg, Kotecha, Brinkman (2024.06.24.600449v1.67) 2012; 81 Kiani, Dupuy, Bruneau, Lebouché, Retière, Geraghty, Bernard (2024.06.24.600449v1.18) 2019; 93 Ward, Davis, DeHart, Zimmerman, Bosque, Brunetta, Mavilio, Planelles, Barker (2024.06.24.600449v1.48) 2009; 5 Jost, Lucar, Lee, Yoder, Kroll, Sugawara, Smith, Jones, Tweet, Werner (2024.06.24.600449v1.21) 2023; 8 Yin, Liu, Wang, Ma, Lei, Zhang, Fu, Fu, Hu, Ding (2024.06.24.600449v1.36) 2018; 9 Garrity, Call, Feng, Wucherpfennig (2024.06.24.600449v1.40) 2005; 102 Song, Lisovsky, Lebouché, Routy, Bruneau, Bernard (2024.06.24.600449v1.13) 2014; 10 Phillips, Rowland-Jones, Nixon, Gotch, Edwards, Ogunlesi, Elvin, Rothbard, Bangham, Rizza (2024.06.24.600449v1.65) 1991; 354 Habegger de Sorrentino, Sinchi, Marinic, López, Iliovich (2024.06.24.600449v1.11) 2013; 140 Alter, Rihn, Walter, Nolting, Martin, Rosenberg, Miller, Carrington, Altfeld (2024.06.24.600449v1.2) 2009; 83 Guo, Jiao, Zhao, Huang, Deng, Zhang, Fan, Xu, Zhang, Zhen (2024.06.24.600449v1.6) 2022; 75 Tremblay-McLean, Bruneau, Lebouché, Lisovsky, Song, Bernard (2024.06.24.600449v1.60) 2017; 9 Schwartz, Maréchal, Le Gall, Lemonnier, Heard (2024.06.24.600449v1.16) 1996; 2 Wu, Song, Bakker, Bauer, Spies, Lanier, Phillips (2024.06.24.600449v1.41) 1999; 285 Boulet, Song, Kamya, Bruneau, Shoukry, Tsoukas, Bernard (2024.06.24.600449v1.44) 2010; 184 Pesce, Tabellini, Cantoni, Patrizi, Coltrini, Rampinelli, Matta, Vivier, Moretta, Parolini (2024.06.24.600449v1.53) 2015; 4 Zhang, Lu, Cheung, Zhang, Liu, Li, Yuan, Wang, Liu, Tang (2024.06.24.600449v1.37) 2021; 12 Nguyen, Roth, Li, Chen, Apathy, Mamedov, Vo, Tobin, Goodman, Shifrut (2024.06.24.600449v1.70) 2020; 38 McKinlay, Vargas, Blake, Hardy, Kanada, Contag, Wender, Waymouth (2024.06.24.600449v1.38) 2017; 114 Korber, Gaschen, Yusim, Thakallapally, Kesmir, Detours (2024.06.24.600449v1.30) 2001; 58 Boudreau, Mulrooney, Le Luduec, Barker, Hsu (2024.06.24.600449v1.17) 2016; 196 Holder, Burt, Grant (2024.06.24.600449v1.35) 2021; 10 Molfetta, Quatrini, Capuano, Gasparrini, Zitti, Zingoni, Galandrini, Santoni, Paolini (2024.06.24.600449v1.52) 2014; 44 Scott-Algara, Truong, Versmisse, David, Luong, Nguyen, Theodorou, Barré-Sinoussi, Pancino (2024.06.24.600449v1.5) 2003; 171 McKechnie, Beltrán, Ferreira, Vergara, Saenz, Vergara, Estripeaut, Araúz, Simpson, Holmes (2024.06.24.600449v1.28) 2020; 4 Waggoner, Kumar (2024.06.24.600449v1.59) 2012; 3 Doubrovina, Doubrovin, Vider, Sisson, O’Reilly, Dupont, Vyas (2024.06.24.600449v1.51) 2003; 171 Wilk, Weidenbacher, Vergara, Haabeth, Levy, Waymouth, Wender, Blish (2024.06.24.600449v1.39) 2020; 4 2024.06.24.600449v1.1 Strauss-Albee, Fukuyama, Liang, Yao, Jarrell, Drake, Kinuthia, Montgomery, John-Stewart, Holmes (2024.06.24.600449v1.69) 2015; 7 |
| References_xml | – reference: 41079618 - iScience. 2025 Sep 12;28(10):113548. doi: 10.1016/j.isci.2025.113548. – year: 2020 ident: 2024.06.24.600449v1.34 article-title: TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells publication-title: AIDS doi: 10.1097/QAD.0000000000002488 – volume: 14 start-page: e0078923 year: 2023 ident: 2024.06.24.600449v1.26 article-title: Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity publication-title: MBio – volume: 9 year: 2024 ident: 2024.06.24.600449v1.33 article-title: The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance publication-title: Sci Immunol – volume: 58 start-page: 19 year: 2001 end-page: 42 ident: 2024.06.24.600449v1.30 article-title: Evolutionary and immunological implications of contemporary HIV-1 variation publication-title: Br. Med. Bull – volume: 105 start-page: 4722 year: 2005 end-page: 4729 ident: 2024.06.24.600449v1.58 article-title: Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244) publication-title: Blood – volume: 34 start-page: 1713 year: 2020 end-page: 1723 ident: 2024.06.24.600449v1.63 article-title: HIV-1 induced changes in HLA-C*03 : 04-presented peptide repertoires lead to reduced engagement of inhibitory natural killer cell receptors publication-title: AIDS – volume: 10 year: 2012 ident: 2024.06.24.600449v1.68 article-title: Preparing a Minimum Information about a Flow Cytometry Experiment (MIFlowCyt) compliant manuscript using the International Society for Advancement of Cytometry (ISAC) FCS file repository (FlowRepository publication-title: org). Curr. Protoc. Cytom. Chapter – volume: 10 start-page: e1003867 year: 2014 ident: 2024.06.24.600449v1.13 article-title: HIV protective KIR3DL1/S1-HLA-B genotypes influence NK cell-mediated inhibition of HIV replication in autologous CD4 targets publication-title: PLoS Pathog – volume: 4 start-page: e1000101 year: 2008 ident: 2024.06.24.600449v1.43 article-title: Lysis of endogenously infected CD4+ T cell blasts by rIL-2 activated autologous natural killer cells from HIV-infected viremic individuals publication-title: PLoS Pathog – volume: 5 start-page: e1000613 year: 2009 ident: 2024.06.24.600449v1.48 article-title: HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response publication-title: PLoS Pathog – ident: 2024.06.24.600449v1.1 – volume: 285 start-page: 730 year: 1999 end-page: 732 ident: 2024.06.24.600449v1.41 article-title: An activating immunoreceptor complex formed by NKG2D and DAP10 publication-title: Science – volume: 109 start-page: 4296 year: 2007 end-page: 4305 ident: 2024.06.24.600449v1.4 article-title: Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals publication-title: Blood – volume: 3 start-page: 377 year: 2012 ident: 2024.06.24.600449v1.59 article-title: Evolving role of 2B4/CD244 in T and NK cell responses during virus infection publication-title: Front. Immunol – volume: 10 start-page: 661 year: 1999 end-page: 671 ident: 2024.06.24.600449v1.15 article-title: The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells publication-title: Immunity – volume: 132 year: 2022 ident: 2024.06.24.600449v1.9 article-title: Human NK cells confer protection against HIV-1 infection in humanized mice publication-title: J. Clin. Invest doi: 10.1172/JCI162694 – volume: 93 year: 2019 ident: 2024.06.24.600449v1.22 article-title: Primary HIV-1 Strains Use Nef To Downmodulate HLA-E Surface Expression publication-title: J. Virol doi: 10.1128/JVI.00719-19 – volume: 102 start-page: 7641 year: 2005 end-page: 7646 ident: 2024.06.24.600449v1.40 article-title: The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure publication-title: Proc. Natl. Acad. Sci. U. S. A – volume: 83 start-page: 6798 year: 2009 end-page: 6805 ident: 2024.06.24.600449v1.2 article-title: HLA class I subtype-dependent expansion of KIR3DS1+ and KIR3DL1+ NK cells during acute human immunodeficiency virus type 1 infection publication-title: J. Virol – volume: 75 start-page: 103794 year: 2022 ident: 2024.06.24.600449v1.6 article-title: Implications of the accumulation of CXCR5+ NK cells in lymph nodes of HIV-1 infected patients publication-title: EBioMedicine – volume: 12 start-page: e1005421 year: 2016 ident: 2024.06.24.600449v1.19 article-title: A Conserved HIV-1-Derived Peptide Presented by HLA-E Renders Infected T-cells Highly Susceptible to Attack by NKG2A/CD94-Bearing Natural Killer Cells publication-title: PLoS Pathog – volume: 171 start-page: 6891 year: 2003 end-page: 6899 ident: 2024.06.24.600449v1.51 article-title: Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma publication-title: J. Immunol – volume: 184 start-page: 2057 year: 2010 end-page: 2064 ident: 2024.06.24.600449v1.44 article-title: HIV protective KIR3DL1 and HLA-B genotypes influence NK cell function following stimulation with HLA-devoid cells publication-title: J. Immunol – volume: 38 start-page: 44 year: 2020 end-page: 49 ident: 2024.06.24.600449v1.70 article-title: Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency publication-title: Nat. Biotechnol – volume: 4 start-page: 4244 year: 2020 end-page: 4255 ident: 2024.06.24.600449v1.39 article-title: Charge-altering releasable transporters enable phenotypic manipulation of natural killer cells for cancer immunotherapy publication-title: Blood Adv – volume: 10 start-page: 909 year: 2019 ident: 2024.06.24.600449v1.46 article-title: The Natural Cytotoxicity Receptors in Health and Disease publication-title: Front. Immunol – volume: 2 start-page: a007039 year: 2012 ident: 2024.06.24.600449v1.64 article-title: The Antibody Response against HIV-1 publication-title: Cold Spring Harb. Perspect. Med – start-page: 1000R year: 2017 ident: 2024.06.24.600449v1.72 article-title: CyTOF workflow: differential discovery in high-throughput high-dimensional cytometry datasets publication-title: F – volume: 115 start-page: 1354 year: 2010 end-page: 1363 ident: 2024.06.24.600449v1.23 article-title: HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing publication-title: Blood – volume: 9 start-page: e87631 year: 2014 ident: 2024.06.24.600449v1.56 article-title: HTLV-1 specific CD8+ T cell function augmented by blockade of 2B4/CD48 interaction in HTLV-1 infection publication-title: PLoS One – volume: 23 start-page: 1277 year: 2017 end-page: 1286 ident: 2024.06.24.600449v1.7 article-title: Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys publication-title: Nat. Med – volume: 5 start-page: a145 issue: 208r year: 2013 ident: 2024.06.24.600449v1.27 article-title: Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry publication-title: Sci. Transl. Med – volume: 12 start-page: 602492 year: 2021 ident: 2024.06.24.600449v1.37 article-title: Analysis of the Characteristics of TIGIT-Expressing CD3-CD56+NK Cells in Controlling Different Stages of HIV-1 Infection publication-title: Front. Immunol – volume: 204 start-page: 3027 year: 2007 end-page: 3036 ident: 2024.06.24.600449v1.12 article-title: Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes publication-title: J. Exp. Med – volume: 33 start-page: 23 year: 2019 end-page: 32 ident: 2024.06.24.600449v1.45 article-title: B7-H6-mediated downregulation of NKp30 in natural killer cells contributes to HIV-2 immune escape publication-title: AIDS – volume: 4 start-page: e1001224 year: 2015 ident: 2024.06.24.600449v1.53 article-title: B7-H6-mediated downregulation of NKp30 in NK cells contributes to ovarian carcinoma immune escape publication-title: Oncoimmunology – volume: 9 start-page: 476 year: 2018 ident: 2024.06.24.600449v1.61 article-title: NKG2D and Its Ligands: “One for All, All for One.” publication-title: Front. Immunol – volume: 90 start-page: 109 year: 2012 end-page: 115 ident: 2024.06.24.600449v1.55 article-title: Decreased expression of DNAM-1 on NK cells from acute myeloid leukemia patients publication-title: Immunol. Cell Biol – volume: 44 start-page: 2761 year: 2014 end-page: 2770 ident: 2024.06.24.600449v1.52 article-title: c-Cbl regulates MICA-but not ULBP2-induced NKG2D down-modulation in human NK cells publication-title: Eur. J. Immunol – volume: 196 start-page: 3398 year: 2016 end-page: 3410 ident: 2024.06.24.600449v1.17 article-title: KIR3DL1 and HLA-B Density and Binding Calibrate NK Education and Response to HIV publication-title: J. Immunol – volume: 110 start-page: 1207 year: 2007 end-page: 1214 ident: 2024.06.24.600449v1.47 article-title: HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts publication-title: Blood – volume: 93 year: 2019 ident: 2024.06.24.600449v1.18 article-title: The Education of NK Cells Determines Their Responsiveness to Autologous HIV-Infected CD4 T Cells publication-title: J. Virol doi: 10.1128/JVI.01185-19 – volume: 7 year: 2022 ident: 2024.06.24.600449v1.8 article-title: Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection publication-title: JCI Insight doi: 10.1172/jci.insight.155601 – volume: 110 start-page: 606 year: 2007 end-page: 615 ident: 2024.06.24.600449v1.49 article-title: Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK-cell lysis publication-title: Blood – volume: 2 start-page: 338 year: 1996 end-page: 342 ident: 2024.06.24.600449v1.16 article-title: Endocytosis of major histocompatibility complex class I molecules is induced by the HIV--1 Nef protein publication-title: Nat. Med – volume: 201 start-page: 2117 year: 2018 end-page: 2131 ident: 2024.06.24.600449v1.29 article-title: Differential Induction of IFN-α and Modulation of CD112 and CD54 Expression Govern the Magnitude of NK Cell IFN-γ Response to Influenza A Viruses publication-title: J. Immunol – volume: 8 year: 2023 ident: 2024.06.24.600449v1.21 article-title: Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis publication-title: Sci Immunol – volume: 180 start-page: 7249 year: 2008 end-page: 7258 ident: 2024.06.24.600449v1.50 article-title: Human tumor-derived exosomes down-modulate NKG2D expression publication-title: J. Immunol – volume: 26 start-page: 511 year: 2020 end-page: 518 ident: 2024.06.24.600449v1.3 article-title: Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection publication-title: Nat. Med – volume: 72 start-page: 1 year: 2016 end-page: 10 ident: 2024.06.24.600449v1.24 article-title: Cell Surface Downregulation of NK Cell Ligands by Patient-Derived HIV-1 Vpu and Nef Alleles publication-title: J. Acquir. Immune Defic. Syndr – volume: 12 start-page: 18 year: 2015 ident: 2024.06.24.600449v1.66 article-title: An integrated map of HIV genome-wide variation from a population perspective publication-title: Retrovirology – volume: 12 start-page: 1282 year: 2021 ident: 2024.06.24.600449v1.62 article-title: SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity publication-title: Nat. Commun – volume: 171 start-page: 5663 year: 2003 end-page: 5667 ident: 2024.06.24.600449v1.5 article-title: Cutting edge: increased NK cell activity in HIV-1-exposed but uninfected Vietnamese intravascular drug users publication-title: J. Immunol – volume: 73 start-page: 5255 year: 1999 end-page: 5264 ident: 2024.06.24.600449v1.31 article-title: Variants from the diverse virus population identified at seroconversion of a clade A human immunodeficiency virus type 1-infected woman have distinct biological properties publication-title: J. Virol – volume: 81 start-page: 727 year: 2012 end-page: 731 ident: 2024.06.24.600449v1.67 article-title: FlowRepository: a resource of annotated flow cytometry datasets associated with peer-reviewed publications publication-title: Cytometry A – volume: 7 start-page: a115 issue: 297r year: 2015 ident: 2024.06.24.600449v1.69 article-title: Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility publication-title: Sci. Transl. Med – volume: 8 start-page: 397 year: 2010 end-page: 409 ident: 2024.06.24.600449v1.25 article-title: Degranulation of natural killer cells following interaction with HIV-1-infected cells is hindered by downmodulation of NTB-A by Vpu publication-title: Cell Host Microbe – volume: 4 start-page: 634 year: 2020 end-page: 647 ident: 2024.06.24.600449v1.28 article-title: Mass Cytometry Analysis of the NK Cell Receptor-Ligand Repertoire Reveals Unique Differences between Dengue-Infected Children and Adults publication-title: Immunohorizons – volume: 19 start-page: 686 year: 2016 end-page: 695 ident: 2024.06.24.600449v1.14 article-title: HIV-1 Vpu Mediates HLA-C Downregulation publication-title: Cell Host Microbe – volume: 22 start-page: 137 year: 2021 ident: 2024.06.24.600449v1.32 article-title: CytoGLMM: conditional differential analysis for flow and mass cytometry experiments publication-title: BMC Bioinformatics – volume: 140 start-page: 273 year: 2013 end-page: 279 ident: 2024.06.24.600449v1.11 article-title: KIR-HLA-A and B alleles of the Bw4 epitope against HIV infection in discordant heterosexual couples in Chaco Argentina publication-title: Immunology – volume: 39 start-page: 733 year: 2007 end-page: 740 ident: 2024.06.24.600449v1.10 article-title: Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1 publication-title: Nat. Genet – volume: 114 start-page: E448 year: 2017 end-page: E456 ident: 2024.06.24.600449v1.38 article-title: Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals publication-title: Proc. Natl. Acad. Sci. U. S. A – volume: 9 start-page: 2341 year: 2018 ident: 2024.06.24.600449v1.36 article-title: Expression of the Inhibitory Receptor TIGIT Is Up-Regulated Specifically on NK Cells With CD226 Activating Receptor From HIV-Infected Individuals publication-title: Front. Immunol – volume: 354 start-page: 453 year: 1991 end-page: 459 ident: 2024.06.24.600449v1.65 article-title: Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition publication-title: Nature – volume: 183 start-page: 4921 year: 2009 end-page: 4930 ident: 2024.06.24.600449v1.54 article-title: Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells publication-title: J. Immunol – volume: 180 start-page: 8159 year: 2008 end-page: 8167 ident: 2024.06.24.600449v1.57 article-title: Molecular basis of the dual functions of 2B4 (CD244) publication-title: J. Immunol – volume: 13 start-page: 1027855 year: 2022 ident: 2024.06.24.600449v1.20 article-title: Disruption of the HLA-E/NKG2X axis is associated with uncontrolled HIV infections publication-title: Front. Immunol – year: 2018 ident: 2024.06.24.600449v1.71 article-title: (R Foundation for Statistical Computing – volume: 10 start-page: e1348 year: 2021 ident: 2024.06.24.600449v1.35 article-title: TIGIT blockade enhances NK cell activity against autologous HIV-1-infected CD4+ T cells publication-title: Clin Transl Immunology – volume: 17 start-page: 487 year: 2003 end-page: 494 ident: 2024.06.24.600449v1.42 article-title: Inability of natural killer cells to destroy autologous HIV-infected T lymphocytes publication-title: AIDS – volume: 9 year: 2017 ident: 2024.06.24.600449v1.60 article-title: Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4+ T Cells publication-title: Viruses doi: 10.3390/v9100295 |
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| Title | NKp30 and NKG2D contribute to natural killer recognition of HIV-infected cells |
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