22 Humanized NOG-EXL mice exhibit improved overall survival and less severe myeloid cell activation relative to humanized NSG-SGM3 mice

BackgroundEngraftment efficiency of human immune cell lineages in super immunodeficient mice varies, and numerous strains have been developed to improve reconstitution of humanized immune system mice. NSG-SGM3 and NOG-EXL mice combine severe immunodeficiency with transgenic expression of human myelo...

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Bibliographic Details

Published in:	Journal for immunotherapy of cancer Vol. 11; no. Suppl 1; p. A24
Main Authors:	Willis, Elinor, Verrelle, Jillian, Banerjee, Esha, Assenmacher, Charles-Antoine, Tarrant, James C, Skuli, Nicolas, Jacobson, Moriah L, Binder, Zev, Radaelli, Enrico
Format:	Journal Article
Language:	English
Published:	London BMJ Publishing Group Ltd 01.11.2023 BMJ Publishing Group LTD BMJ Publishing Group
Subjects:	Hyperplasia Immunotherapy Regular and Young Investigator Award Abstracts Stem cells
ISSN:	2051-1426
Online Access:	Get full text
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