99 T cell immunotherapies trigger neutrophil activation to eliminate tumor antigen escape variants

BackgroundTargeted immune-based therapies such as adoptive T cell transfer (ACT) are often ineffective because tumors evolve over time and under selective pressure display antigen loss variant clones. A classic example in melanoma is de-differentiation and loss of expression of antigenic proteins. T...

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Bibliographic Details

Published in:	Journal for immunotherapy of cancer Vol. 9; no. Suppl 2; p. A108
Main Authors:	Hirschhorn, Daniel, Budhu, Sadna, Schröder, David, kraehenbuehl, Lukas, Flammar, Anne-Laurent, Chow, Andrew, Schulze, Isabell, Schad, Sara, Ricca, Jacob, Gasmi, Billel, Henau, Olivier De, Mangarin, Levi, Redmond, David, Cortez, Czrina, Liu, Cailian, Holland, Aliya, Gigoux, Mathieu, Arora, Asrhi, Panageas, Katherine, Rizzuto, Gabrielle, Albrengues, Jean, Egeblad, Mikala, Wolchok, Jedd, Merghoub, Taha
Format:	Journal Article
Language:	English
Published:	London BMJ Publishing Group Ltd 01.11.2021 BMJ Publishing Group LTD BMJ Publishing Group
Subjects:	Antigens Immunotherapy Melanoma Neutrophils Regular and Young Investigator Award Abstracts Tumors
ISSN:	2051-1426
Online Access:	Get full text
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