Spinal motoneuron excitability is homeostatically-regulated through β-adrenergic neuromodulation in wild-type and presymptomatic SOD1 mice

Homeostatic feedback loops are essential to stabilize the activity of neurons and neuronal networks. It has been hypothesized that, in the context of Amyotrophic Lateral Sclerosis (ALS), an excessive gain in feedback loops might hyper- or hypo-excite motoneurons (MNs) and contribute to the pathogene...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	bioRxiv
Hlavní autoři:	Antonucci, Stefano, Caron, Guillaume, Dikwella, Natalie, Krishnamurty, Sruthi Sankari, Harster, Anthony, Zarrin, Hina, Tahanis, Aboud, Heuvel, Florian Olde, Danner, Simon M, Ludolph, Albert C, Grycz, Kamil, Bączyk, Marcin, Zytnicki, Daniel, Roselli, Francesco
Médium:	Journal Article Paper
Jazyk:	angličtina
Vydáno:	United States Cold Spring Harbor Laboratory Press 20.12.2024 Cold Spring Harbor Laboratory
Vydání:	3.1
Témata:	Adrenergic receptors Amyotrophic lateral sclerosis Down-regulation Electrical properties Excitability Feedback Motor neurons Neural networks Neuromodulation Neuroscience Receptor mechanisms Superoxide dismutase β-adrenergic neuromodulation Amyotrophic Lateral Sclerosis homeostatic feedbacks in vivo intracellular electrophysiology Spinal motoneurons transcriptomics GPCR channelome
ISSN:	2692-8205, 2692-8205
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!