287 A new UK reproductive care pathway for women with serious MTDNA disease
In March 2015, the UK government passed into law, an amendment to the Human Fertilisation and Embryology Act 1990 to permit ‘Mitochondrial Donation’. This provided a unique legal framework for techniques that make it possible to ‘replace’ mutated mitochondrial DNA (mtDNA) in human oocytes or zygotes...
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| Published in: | Journal of neurology, neurosurgery and psychiatry Vol. 89; no. 10; p. A44 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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BMJ Publishing Group LTD
01.10.2018
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| ISSN: | 0022-3050, 1468-330X |
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| Abstract | In March 2015, the UK government passed into law, an amendment to the Human Fertilisation and Embryology Act 1990 to permit ‘Mitochondrial Donation’. This provided a unique legal framework for techniques that make it possible to ‘replace’ mutated mitochondrial DNA (mtDNA) in human oocytes or zygotes. As a group, primary mtDNA diseases are the most prevalent of the inherited neurometabolic disorders, affecting up to 1 in 5000 live births and can often have devastating clinical consequences. To date, treatments focus on palliation of symptoms, while the emergence of reproductive techniques, such as Mitochondrial Donation, offers the first real opportunity to prevent the maternal transmission of some serious forms of mtDNA disease. The Human Fertilization and Embryo Authority (HFEA), the statutory regulatory authority charged with regulating human embryo research in the UK, has devised, a detailed regulatory process for Mitochondrial Donation. To ensure compliance with the HFEA regulations we describe how we have established a high quality, integrated care pathway that provides care that is available to anyone in the UK, and comprehensively involves pathways for couples seeking reproductive advice, IVF pathway for potential mothers with pathogenic mtDNA mutations, a pathway for donors and long-term follow up of children born. |
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| AbstractList | In March 2015, the UK government passed into law, an amendment to the Human Fertilisation and Embryology Act 1990 to permit ‘Mitochondrial Donation’. This provided a unique legal framework for techniques that make it possible to ‘replace’ mutated mitochondrial DNA (mtDNA) in human oocytes or zygotes. As a group, primary mtDNA diseases are the most prevalent of the inherited neurometabolic disorders, affecting up to 1 in 5000 live births and can often have devastating clinical consequences. To date, treatments focus on palliation of symptoms, while the emergence of reproductive techniques, such as Mitochondrial Donation, offers the first real opportunity to prevent the maternal transmission of some serious forms of mtDNA disease. The Human Fertilization and Embryo Authority (HFEA), the statutory regulatory authority charged with regulating human embryo research in the UK, has devised, a detailed regulatory process for Mitochondrial Donation. To ensure compliance with the HFEA regulations we describe how we have established a high quality, integrated care pathway that provides care that is available to anyone in the UK, and comprehensively involves pathways for couples seeking reproductive advice, IVF pathway for potential mothers with pathogenic mtDNA mutations, a pathway for donors and long-term follow up of children born. |
| Author | Louise, Heslop Mary, Herbert Catherine, Feeney Robert, Taylor Julie, Murphy Jane, Stewart Doug, Turnbull Grainne, Gorman Emma, Blakeley Robert, McFarland |
| Author_xml | – sequence: 1 givenname: Gorman surname: Grainne fullname: Grainne, Gorman organization: Newcastle Fertility Centre at Life – sequence: 2 givenname: McFarland surname: Robert fullname: Robert, McFarland organization: Newcastle Fertility Centre at Life – sequence: 3 givenname: Stewart surname: Jane fullname: Jane, Stewart organization: Newcastle Fertility Centre at Life – sequence: 4 givenname: Feeney surname: Catherine fullname: Catherine, Feeney organization: Newcastle Fertility Centre at Life – sequence: 5 givenname: Herbert surname: Mary fullname: Mary, Herbert organization: Newcastle Fertility Centre at Life – sequence: 6 givenname: Heslop surname: Louise fullname: Louise, Heslop organization: Newcastle Fertility Centre at Life – sequence: 7 givenname: Blakeley surname: Emma fullname: Emma, Blakeley organization: Newcastle Fertility Centre at Life – sequence: 8 givenname: Taylor surname: Robert fullname: Robert, Taylor organization: Newcastle Fertility Centre at Life – sequence: 9 givenname: Murphy surname: Julie fullname: Julie, Murphy organization: Newcastle Fertility Centre at Life – sequence: 10 givenname: Turnbull surname: Doug fullname: Doug, Turnbull organization: Newcastle Fertility Centre at Life |
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| ContentType | Journal Article |
| Copyright | 2018, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2018 2018, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions |
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| DOI | 10.1136/jnnp-2018-ABN.151 |
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| Snippet | In March 2015, the UK government passed into law, an amendment to the Human Fertilisation and Embryology Act 1990 to permit ‘Mitochondrial Donation’. This... |
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| Title | 287 A new UK reproductive care pathway for women with serious MTDNA disease |
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