Positive and negative control of helicase recruitment at a bacterial chromosome origin

The mechanisms responsible for helicase loading during the initiation of chromosome replication in bacteria are unclear. Here we report both a positive and a negative mechanism for directing helicase recruitment in the model organism Bacillus subtilis. Systematic mutagenesis of the essential replica...

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Bibliographic Details
Published in:	bioRxiv
Main Authors:	Winterhalter, Charles, Stevens, Daniel, Fenyk, Stepan, Pelliciari, Simone, Marchand, Elie, Cronin, Nora B, Soultanas, Panos, Costa, Tiago, Ilangovan, Aravindan, Heath, Murray
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.08.2021 Cold Spring Harbor Laboratory
Edition:	1.1
Subjects:	Chromosomes DNA biosynthesis DNA helicase Drug development Interfaces Microbiology Mutagenesis Nucleotide sequence Replication initiation Replication origins Single-stranded DNA replication SirA initiation DNA origin DnaA helicase DnaD
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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