An integrated approach to identify environmental modulators of genetic risk factors for complex traits

Abstract Complex traits and diseases can be influenced by both genetics and environment. However, given the large number of environmental stimuli and power challenges for gene-by-environment testing, it remains a critical challenge to identify and prioritize specific disease-relevant environmental e...

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Bibliographic Details
Published in:	bioRxiv
Main Authors:	Balliu, Brunilda, Ivan Carcamo -Orive, Gloudemans, Michael J, Nachun, Daniel C, Durrant, Matthew G, Gazal, Steven, Park, Chong Y, Knowles, David A, Wabitsch, Martin, Quertermous, Thomas, Knowles, Joshua W, Montgomery, Stephen B
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 25.02.2021 Cold Spring Harbor Laboratory
Edition:	1.1
Subjects:	Cell lines Disease Environmental effects Genetic diversity Genomics Hepatocytes Heritability Homeostasis Insulin Insulin resistance Phenotypes Polygenic inheritance Risk factors Skeletal muscle Transcription Co-localization GWAS Gene expression Gene-by-environment interactions
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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