USP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells

Altering ubiquitination by disruption of individual deubiquitinating enzymes (DUBs) has proven to affect hematopoietic stem cell (HSC) maintenance. However, comprehensive knowledge of DUB function during hematopoiesis in vivo is lacking. To accomplish this goal, we systematically inactivated DUBs in...

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Bibliographic Details
Published in:	bioRxiv
Main Authors:	Van Den Berk, Paul, Lancini, Cesare, Company, Carlos, Serresi, Michela, Hulsman, Danielle, Pritchard, Colin, Ji-Ying, Song, Schmitt, Matthias Jurgen, Tanger, Ellen, Huijbers, Ivo J, Jacobs, Heinz, Maarten Van Lohuizen, Gargiulo, Gaetano, Citterio, Elisabetta
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 24.01.2020 Cold Spring Harbor Laboratory
Edition:	1.1
Subjects:	Genetics Genomes Genotoxicity Hematopoietic stem cells Leukemia Myeloid leukemia Progenitor cells Rodents Stem cell transplantation Ubiquitin Ubiquitin-specific proteinase Ubiquitination USP15 shRNA screen Genome Integrity Deubiquitinase Hematopoietic Stem Cell (HSC) Leukemia Deubiquitinating Enzymes DNA Damage
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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