Colorectal cancer progression is potently reduced by a glucose-free, high-protein diet: comparison to anti-EGFR therapy

Background & Aims: To enable rapid proliferation, colorectal tumor cells up-regulate epidermal growth factor receptor (EGFR) signaling and perform high level of aerobic glycolysis, resulting in substantial lactate release into the tumor microenvironment and impaired anti-tumor immune responses....

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Bibliographic Details
Published in:	bioRxiv
Main Authors:	Skibbe, Kerstin, Ann-Kathrin Brethack, Suenderhauf, Annika, Ragab, Mohab, Raschdorf, Annika, Hicken, Maren, Schlichting, Heidi, Preira, Joyce, Brandt, Jennifer, Castven, Darko, Foeh, Bandik, Pagel, Rene, Marquardt, Jens U, Sina, Christian, Derer, Stefanie
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.06.2021 Cold Spring Harbor Laboratory
Edition:	2.1
Subjects:	Amino acids Antibodies Azoxymethane Cancer Biology Cell culture Cell differentiation Cell proliferation Colitis Colorectal carcinoma Dextran Down-regulation Energy balance Epidermal growth factor Epidermal growth factor receptors Epithelial cells Glucose Glycolysis High protein diet Homeostasis Immune response Immunotherapy Lymphocytes T Metastases PD-L1 protein Spleen Tumor cells Tumor microenvironment Tumors
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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