Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer

Although cancer immunotherapy with PD-(L)1 blockade is now routine treatment for patients with lung cancer, remarkably little is known about acquired resistance. We examined 1,201 patients with NSCLC treated with PD-(L)1 blockade to clinically characterize acquired resistance, finding it to be commo...

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Bibliographic Details
Published in:	bioRxiv
Main Authors:	Memon, Danish, Rizvi, Hira, Fromm, George, Lihm, Jayon, Schoenfeld, Adam J, Sauter, Jennifer L, Luo, Jia, Chow, Andrew, Bhanot, Umesh K, Mccarthy, Caroline, Ye, Darwin, Vanderbilt, Chad M, Liu, Cailian, Abu-Akeel, Mohsen, Plodkowski, Andrew J, Mcgranahan, Nicholas, Luksza, Marta, Greenbaum, Benjamin D, Taha Merghoub, Minn, Andy J, Beltrao, Pedro, Schreiber, Taylor H, Miller, Martin L, Hellmann, Matthew D
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 22.07.2021 Cold Spring Harbor Laboratory
Edition:	1.1
Subjects:	Animal models Antigen presentation Cancer Biology Cancer immunotherapy CD8 antigen Genomics Immune system Immunotherapy Inflammation Lung cancer Lymphocytes T Metastases Non-small cell lung carcinoma Patients Phenotypes Small cell lung carcinoma Transcriptomes Tumor microenvironment Tumors γ-Interferon
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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