Molecular dependencies and genomic consequences of a global DNA damage tolerance defect

DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. To determine the molecular and genomic impact of a global DDT defect, we studied PcnaK164R/-;Rev1-/- compound mutants. Double mutant (DM) cells displayed increased replication stress, hypersensitivit...

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Bibliographic Details

Published in:	bioRxiv
Main Authors:	Groot, Daniel De, Spanjaard, Aldo, Shah, Ronak, Kreft, Maaike, Morris, Ben, Cor Lieftink Sr, Joyce Ji Catsman, Ormel, Shirley, Ayidah, Matilda, Pilzecker, Bas, Buoninfante, Olimpia Alessandra, Paul Cm Van Denberk, Beijersbergen, Roderick L, Jacobs, Heinz
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 06.11.2023 Cold Spring Harbor Laboratory
Edition:	1.2
Subjects:	CRISPR DNA damage Genomes Genomics Genotoxicity Molecular Biology Mutants Replication Whole genome sequencing
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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