Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

ABSTRACT Our understanding of protective vs. pathologic immune responses to SARS-CoV-2, the virus that causes Coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of patients at the extremes of the disease severity spectrum. Here, we performed multi-omic single-cell immune profili...

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Bibliographic Details

Published in:	bioRxiv
Main Authors:	Wilk, Aaron J, Lee, Madeline J, Wei, Bei, Parks, Benjamin, Pi, Ruoxi, Martínez-Colón, Giovanny J, Ranganath, Thanmayi, Zhao, Nancy Q, Taylor, Shalina, Becker, Winston, Stanford Covid-19 Biobank, Jimenez-Morales, David, Blomkalns, Andra L, Ruth O’hara, Ashley, Euan A, Nadeau, Kari C, Yang, Samuel, Holmes, Susan, Rabinovitch, Marlene, Rogers, Angela J, Greenleaf, William J, Blish, Catherine A
Format:	Paper
Language:	English
Published:	Cold Spring Harbor Cold Spring Harbor Laboratory Press 18.12.2020 Cold Spring Harbor Laboratory
Edition:	1.1
Subjects:	Coronaviruses COVID-19 Immune response Immunology Inflammation Innate immunity Leukocytes (neutrophilic) Monocytes Myelopoiesis Phenotypes Proteomics Severe acute respiratory syndrome coronavirus 2
ISSN:	2692-8205, 2692-8205
Online Access:	Get full text
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